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Sensory Guillain-Barre malady pursuing the ChAdOx1 nCov-19 vaccine: Report regarding a couple of cases as well as overview of books.
Serologic detection for anti-SARS-CoV-2 IgG and/or IgM is an important test in the assistant diagnosis of COVID-19.The number of reported cases of the new coronavirus disease named "severe acute respiratory syndrome-coronavirus 2" (SARS-CoV-2) has increased since December 2019. The initial high-resolution computed tomography (HRCT) images of seven patients with diagnosed COVID-19 in the Affiliated Hospital of Hangzhou Normal University, China, were collected and analyzed. The study showed that all patients had close contact with COVID-19 patient and presented with fever. The initial white blood cell counts of all patients were normal. The percentage of lymphocytes decreased in three patients. In all seven patients with COVID-19, ground glass opacity (GGO) was found in the HRCT images, mainly distributed in the subpleural region of the lungs. The HRCT scans of six patients showed bilateral lobar lesions, mainly peripheral subpleural distribution; one patients showed unilateral lobar involvement. The right lung was more extensively involved than the left lung in six patients, and the lower lobe was more extensively involved than the upper lobe in five patients. The initial chest HRCT images of the lungs of COVID-19 patients had specific characteristics; the typical manifestations of the bilateral lungs showed extensive GGO-type infiltrate, with thickened vascular bundles and focal center consolidation. Pleural effusion, bilateral hilar, and mediastinal lymphadenopathy were rare.Rotavirus and norovirus are well-known causes of viral infectious diarrhea. There are few reports about diarrhea caused by other viruses in Korea, although gastroenteritis attributable to other viruses is increasing worldwide. The aims of this study were to detect various causes of viral diarrhea and to investigate their prevalence. A total of 801 fecal specimens submitted to a clinical microbiology laboratory for the detection of diarrhea viruses were included. We sought to detect rotavirus A/B/C, adenovirus, astrovirus, norovirus GI/GII, sapovirus, Aichi virus, human parechovirus, enterovirus, human cosavirus, human bocavirus, and Saffold virus using multiplex RT-PCR. At least one diarrhea virus was detected in 223 (27.8%) fecal specimens. Among them, two viruses were detected in each of 11 specimens. Rotavirus A was most common (17.1%; N=137), followed by norovirus GII (5.0%; N=40), enterovirus (4.2%; N=34), adenovirus (1.0%; N=8), astrovirus (1.0%; N=8), human parechovirus (0.6%; N=5), and human bocavirus (0.2%; N=2). Rotaviruses B and C, norovirus GI, sapovirus, Aichi virus, human cosavirus, and Saffold virus were not found. We confirmed that various diarrheal viruses can be detected in fecal specimens. We need to consider the possibility of viruses other than rotavirus and norovirus being present in cases of diarrhea.In December 2019, there was an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. The number of patients in China has risen to 31,000. We collected patient data from four Chinese cities (Hefei, Hangzhou, Wenzhou, Shenzhen) and described epidemiologic characteristics. As of 6 February 2020, we extracted data from 950 patients from the four cities. There were 477 (50.21%) males and 473 (49.79%) females of age (mean ± SD) 45.64 ± 15.59 years. Before contracting COVID-19, 299 patients had contact with Wuhan residents or contact with patients diagnosed with COVID-19 (31.47%). Also, 138 patients had SARS-CoV-2 infection of unknown source (14.53%). COVID-19 patients in the four cities were mainly from Wuhan originally, and had spread infection locally. Therefore, the initial stage of SARS-CoV-2 transmission in cities outside Wuhan were mainly input. learn more Cutting off input and controlling community communication would reduce local incidence.We investigated the relationship between colibactin-producing (clb+) Escherichia coli and colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and surrounding non-tumor regions in resected specimens from 34 Japanese patients; 450 colonies were from tumor regions and 279 from non-tumor regions. clb+ bacteria were found in tumor regions of 11 patients (11/34, 32.4%) and in non-tumor regions of seven of the 11 (7/34, 20.6%). The prevalence of clb+ isolates was 72.7% (327/450) and 44.1% (123/279) in tumor and non-tumor regions, respectively. All the recovered clb+ isolates belonged to the phylogenetic group B2 and were the most predominant type in tumor regions. Hemolytic (α-hemolysin-positive, hlyA+) and non-hemolytic (α-hemolysin-negative, hlyA-) clb+ isolates were obtained from patient #19; however, the prevalence of hlyA+ clb+ isolates was significantly higher in tumor regions (35/43, 81.4%) than in non-tumor regions (3/19, 15.8%). Moreover, a significantly higher production of N-myristoyl-D-asparagine, a byproduct of colibactin biosynthesis, was observed in hlyA+ clb+ isolates than in hlyA- clb+ isolates. Our results suggest that hlyA+ clb+ E. coli may have a selective advantage in colorectal colonization, consequently playing a role in carcinogenesis. The presence of hlyA+ clb+ bacteria in healthy individuals is a risk marker of colorectal cancer.Dengue virus (DENV), one of the most rapidly spreading mosquito-borne pathogens, causes acute febrile illness with various clinical symptoms. Four DENV serotypes are known, designated DENV-1 to -4. We previously determined whole-genome sequences of 21 DENV isolates obtained during 2016-2017 and reported the emergence of the Cosmopolitan genotype of DENV-2 and genotype III of DENV-3 in Thailand. The objective of the present study, conducted in 2018 at the Bamrasnaradura Infectious Diseases Institute, was to characterize the DENV genotype distribution among severe dengue patients. A total of 100 hospitalized severe dengue patients were enrolled with written informed consent. Serum specimens were tested by multiplex real-time reverse transcription-polymerase chain reaction. A total of 94 cases were DENV detected, with 46 DENV-1, 38 DENV-2, 10 DENV-4, and no DENV-3 cases. Sequence determination of the DENV envelope-protein gene was successful in 73 cases. Genotyping of the resultant sequences revealed 40 DENV-1 genotype I, 26 DENV-2 including 18 genotype Cosmopolitan and 8 genotype Asian I, and 7 DENV-4 genotype I cases.
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