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Metabolomics throughout Workout as well as Sports: A planned out Evaluation.
01). Genipin was not detected in rat plasma after administration of the GIGF extract, but it can be detected in plasma after administration of CGF, SGF, and GCGF extract. Furthermore, crocin I and crocin II were not detected in plasma samples. Crocetin had higher concentration in rat plasma versus lower contents in extract. It was demonstrated that the different processing methods might influence the pharmacokinetics of geniposidic acid, genipin-1-β-gentiobioside, geniposide, genipin, and crocetin.Objective To undertake an overview on the overall effects of Tripterygium glycosides (TG) combined with Leflunomide (LEF) for rheumatoid arthritis (RA). see more Methods We searched electronic databases from database establishment time to December 1, 2019. The clinical trial data of TG combined with LEF (trial group) and control group in the treatment of RA were collected. The Cochrane system was used to evaluate the quality of the literature. RevMan 5.3 software was used to conduct a meta-analysis of the eligible studies. Results A total of 12 randomized controlled trials (RCTs) involving 834 patients with RA were included in this study. The meta-analysis results showed that morning stiffness (mean difference (MD) = -0.29, 95% confidential interval (CI) (-0.45, -0.12), P=0.0005), tender joint count (MD = -1.51, 95% CI (-2.20, -0.83), P=0.0001), swollen joint count (MD = -1.24, 95% CI (-1.59, -0.88), P=0.0001), erythrocyte sedimentation rate (MD = -7.26, 95% CI (-9.92, -4.61), P=0.0001), C-reactive protein (MD = -4.04, 95% CI (-4.93, -3.14), P=0.0001), and rheumatoid factor (MD = -50.88, 95% CI (-72.30, -29.45), P = 0.0001) in the trial groups were lower than those in the control groups. The total effective rate in the trial group was better than that in the control group (risk ratio (RR) = 1.20, 95% CI (1.13, 1.28), P=0.00001). However, there was no significant difference of adverse events (RR = 0.83, 95% CI (0.61, 1.13), P=0.23) while comparing the trial groups with the control groups. Conclusion Our results were found to be superior but limited evidence on the effectiveness of TG combined with LEF in the treatment of RA is available.Background At present, the prevention and treatment of cardiovascular disease in the world are facing severe challenges. Xinmailong injection, which is derived from the animal medicine Periplaneta Americana, has certain advantages in the clinical treatment of cardiovascular disease. This study systematically evaluated the basic research reports of Xinmailong Injection on cardiovascular disease and made its pharmacological mechanisms more clear. Methods Basic research reports on the intervention mechanisms of Xinmailong Injection on cardiovascular disease in PubMed, EMBASE, Cochrane Library (No. 2, 2019), CNKI, Wan Fang, and VIP databases were searched. The search time limit was from the establishment of the database to February 2019. The literature was screened according to inclusion and exclusion criteria, and then the data were extracted and a descriptive analysis of the pharmacological mechanisms of Xinmailong Injection on cardiovascular disease was performed. Results Finally, twenty-two basic research reperefore, Xinmailong Injection has great potential for clinical application, and more basic researches need to be carried out to explore the medicinal value of Xinmailong Injection.Background Vehicle repair work is one of the highest risk professions for work-related musculoskeletal disorders. Globally, only a few published studies have examined the prevalence and determinants of work-related musculoskeletal disorders among vehicle repair workers. Related studies in Ethiopia are even fewer. This study aimed to determine the prevalence of self-reported work-related musculoskeletal disorders and associated factors among vehicle repair workers in Hawassa city, South Ethiopia, 2019. Methods An institution-based cross-sectional study was conducted among 344 vehicle repair workers in the Hawassa city. The Nordic Musculoskeletal Questionnaire-Extended (NMQ-E) was used to assess work-related musculoskeletal disorders on nine body regions. Descriptive statistics and multivariable analyses were used to characterize the data and identify factors associated with work-related musculoskeletal disorders. Result The twelve-month prevalence of work-related musculoskeletal disorders among this working group was 47.7% with 95% CI (42.7-53.2). Jobs continuously requiring repetitive motions (AOR 4.29, 95% CI (1.78-10.2)), not having professional training (AOR 2.04, 95% CI (1.09-3.81)), force exertion when using tools (AOR 2.40, 95% CI (1.24-4.62)), job stress (AOR4.54, 95% CI (2.44-8.46)), and regularly lifting, pushing, and pulling loads greater than 20 kg (AOR4.85, 95% CI (2.65-8.87)) were identified as associated factors. Conclusion This study showed a 47.7% prevalence of work-related musculoskeletal disorders. Force exertion, repetitive tasks, manual handling of heavy loads, stress, and lack of training were the identified factors. Ergonomic awareness among workers should be increased through training. In addition, owners should investigate methods to reduce or eliminate risk factors leading to musculoskeletal disorders found among these workers. Automation of high-risk tasks should also be investigated.Objective The integrity and the wholesomeness of the food served to school pupils cannot be overlooked, especially when one considers the magnitude of health and sanitation issues that are plaguing the West African nations. This study aimed to investigate some of the personal hygiene practices by the pupils and the hygienic conditions in which food is cooked and served to these school-going children under the Ghana School Feeding Programme (GSFP). Design A cross-sectional and descriptive survey research designs were used in the study. Purposive and simple random sampling techniques were employed in selecting participants. Participants. There were 720 respondents for the study, comprising 600 pupils, 60 teachers, and 60 kitchen staff members from 20 schools. Information was obtained using questionnaire, observation, and unstructured interview instruments. Results Findings from the study revealed that the majority of pupils (92% in Wa and 65% in Cape Coast) did not wash their hands with soap under running water.
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