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Autosomal recessive Alport syndrome caused by a fresh COL4A4 compound heterozygous mutation: An instance document.
Among them, positive expression was also found in part of the capillary endothelium, and in smooth muscle cells of the vessel wall There is also a small amount of expression. The MIF IOD value of the dust-exposed group was compared with the control group at each time point, and the difference was statistically significant(P<0. 05).

Both NF-κB and MIF are positively expressed in the lung tissue of silica-exposed rats, which has certain reference significance in the early diagnosis and treatment of silicosis in the future.
Both NF-κB and MIF are positively expressed in the lung tissue of silica-exposed rats, which has certain reference significance in the early diagnosis and treatment of silicosis in the future.
To study the safety of eight nucleic acid dyes EB, GelGreen, GoldView, GeneGreen, SYBRGreen I, GelRed, SYBRSafe and SYBRGold.

Salmonell atyphimurium TA97, TA98, TA100 and TA102 involved in the minimum inhibitory concentration(MIC) of the 8 nucleic acid dyes by the Broth dilution, which follows Clinical and Laboratory Standards Institute. Nacetylcysteine The experiment tests the reverse mutation of bacteria with the 8 nucleic acid dyes, which follows GB 15193. 4-2014.

EB and its metabolites show significant mutagenicity on TA97, TA98, TA100 and TA102. SYBRGold and its metabolites do not show mutagenicity on TA97, TA98, TA100 and TA102. The other six dyes show varying mutagenicity on TA97, TA98 and TA102, meanwhile show no mutagenicity on TA100.

This research shows that, except EB, the other dyes show no mutagenicity under working concentration, but show varying mutagenicity under high concentration. SYBRSafe and SYBRGreenI are highly toxic, and the operators must have high precautions when making diluted solution of them.
This research shows that, except EB, the other dyes show no mutagenicity under working concentration, but show varying mutagenicity under high concentration. SYBRSafe and SYBRGreenI are highly toxic, and the operators must have high precautions when making diluted solution of them.
To investigate the effect of resveratrol(Res) combined with soy isoflavones(SIF) on apoptosisinduced by oxidative stress in hippocampus in aging model rats.

Sixty female SD rats were randomly divided into the Sham control group, aging model group, Res treatment group, SIF treatment group, Res combined with SIF treatment group and estrogen replacement therapy group(ERT group). Rats with aging were induced by bilateral ovariectomy combined with intraperitoneal injection of D-galactose. TUNEL and transmission electron microscopy were used to observe apoptosis and ultrastructural changes of mitochondrion in hippocampus, respectively. The activities of superoxide dismutase(SOD), catalase(CAT), glutathione peroxidase(GSH-Px) and content of Malonaldehyde(MDA) were detected in the hippocampal homogenate. The protein expressions of cytochrome C oxidase(COX) Ⅰ, Bcl-2 associated X protein(Bax)、B-cell leukemia/lymphoma 2(Bcl-2) and cytochrome C were detected by Western blot.

Compared with the Sham control group, thratio of Bcl-2 and Bax, and inhibiting the release of cytochrome C may be the mechanisms by which Res and SIF improve apoptosis in aging rats.
To investigate the relationship between vitamin D binding protein gene rs2282679 A/C polymorphism with blood vitamin D levels.

A total of 286 eligible subjects were selected from one university in Hebei Province. Serum 25-hydroxylated vitamin D levels were measured by liquid chromatography-mass spectrometry, and gene chip was used for genotyping of rs2282679 locus. Statistical analysis was performed using R software.

A total of 285 participants in the study completed the experiment, and result indicated that the distribution of the rs2282679 locus A/C polymorphism in the participants was consistent with the Hardy-Weinberg equilibrium. The genotype of rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency(P=0. 031). Allele A was a risk factor for vitamin D insufficiency and deficiency. The OR value of allele C relative to A was 0. 65, and the genetic pattern of allele C relative to A was dominant(P=0. 03).

The vitamin D-binding protein gene rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency in college students, and A-allele is a risk factor accounting for vitamin D insufficiency and deficiency in college students.
The vitamin D-binding protein gene rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency in college students, and A-allele is a risk factor accounting for vitamin D insufficiency and deficiency in college students.
To determine the concentration of fluctuating gaseous formaldehyde in an anatomy laboratory and to investigate its effects on the subjective symptoms and the lung functions of medical students working there.

To measure the levels of formaldehyde gas at different physical ventilation times at the center of the study laboratory by the gaseous formaldehyde detector. A total of 251 of second-year medical students were randomly selected from 1004 students participating in the anatomy operation as the survey subjects, 77 medical students were randomly selected for lung function assessment. The subjective symptoms of the medical students exposed to this gas were investigated via questionnaire surveys before, during and after the dissection operation. The probable lung function damages caused by the exposure before and after the operation were also measured using various parameters.

The concentration of gaseous formaldehyde decreased with an increase in the ventilation time(P<0. 05), but it was always hiExisting physical ventilation facilities are difficult to reduce the concentration of gaseous formaldehyde below the safety threshold. Exposure to ultra-high concentrations of gaseous formaldehyde caused a significant increase in subjective symptoms of medical students with secondary pulmonary function impairment.
Existing physical ventilation facilities are difficult to reduce the concentration of gaseous formaldehyde below the safety threshold. Exposure to ultra-high concentrations of gaseous formaldehyde caused a significant increase in subjective symptoms of medical students with secondary pulmonary function impairment.
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