Notes

Discovery of your Strong Two SLK/STK10 Inhibitor Based on a Maleimide Scaffolding.
Dr Durán is a native of eastern San-tiago de Cuba and his early medical career began in this mountainous re-gion, where he also headed provin-cial prevention and treatment of HIV/AIDS. He went on to become rector of the Medical University of Santiago de Cuba and provincial health direc-tor. Later in Havana, Dr Durán was director of medical education and vice minister at the Ministry of Public Health (MINSAP). Abroad, he served as advisor to Angola's Minister of Health, and on his return, as deputy director of Cuba's Pedro Kourí Tropical Medicine Institute (IPK). Selleckchem Celastrol Dr Durán has been "battle-tested" over the years by his involvement in stemming dengue epidemics and other infectious dis-ease outbreaks, good preparation for his current position as National Direc-tor of Epidemiology. Today, his is the voice and the face on the 1100 AM briefing carried daily by Cuban television, reporting the latest data on the un-folding COVID-19 pandemic globally, in the Americas and.As the COVID-19 health crisis engulfs the planet, we are sub-merged in a parallel pandemic the glut of misinformation and disinformation. The data associated with this phenomenon are creating a disaster within a disaster. In early April 2020, the Span-ish news agency EFE[1] reported that over one million internet ac-counts were dedicated to rumor-mongering, spreading unverifi ed information about the coronavirus. From January through April 13, fact-checkers at Maldita.es[2] had tracked over 400 lies and false alerts circulated about COVID-19 in Spain alone.This MEDICC Review roundtable brings you specialists from Havana's Pedro Kourí Tropical Medicine Institute (IPK), who are working directly with testing, research and patient care during the COVID-19 pandemic. Founded in 1937 by its namesake, the Institute has gained considerable worldwide prestige. Today, it is a PAHO-WHO Collaborating Center for the Study of Dengue and Its Vector, and for the Elimination of Tuberculosis. Its main role within Cuba's health system is as the national reference center for prevention, control, management and elimination of infectious diseases, including epidemics. Its 479 workers staff 32 departments, including laboratories, research and teach-ing facilities, a hospital and isolation center. The IPK's hospital treats later-stage AIDS patients, while the Institute is the nation-al reference center for attention to all HIV-positive patients and maintains the national HIV/AIDS registry, as well as registries for other infectious diseases. The institution was responsible for training the Cuban doctors who served in West Africa during the 2014-2016 Ebola outbreaks and for those going abroad to assist in the COVID-19 response today, and its professionals offer an internationally-recognized biennial course on dengue.The main characteristics and challenging symptoms of COVID-19, caused by the novel coronavirus SARS-CoV-2, are related to re-spiratory distress. Although most patients have mild symptoms such as fever, headache, cough, myalgia and anosmia, some develop acute respiratory distress syndrome, leading to death in many cases. Human coronavirus (CoVs) were responsible for two previ-ous worldwide outbreaks Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV). Several reports of these outbreaks demonstrated that these diseases affected the central nervous system (CNS).[1] Thus, for the current COVID-19 pandemic, a crucial question arises does CNS affection at least partially explain the respiratory distress commonly found in these patients?This MEDICC Review roundtable gathers some of Cuba's top researchers in the fi elds of vaccines and biotechnology, all of whom work in institutions belonging to BioCubaFarma, the umbrella company of Cuban biotech and pharmaceutical R&D, production, distribution and export. Founded in 2012, the company is comprised of 34 enterprises with 61 lines of production and some 20,000 employees. A total of 765 of its products are registered in 53 countries and exported to an-other 50. Its scientists' research has resulted in 2640 patents in Cuba and globally.Dr Armando De Negri Filho is an epide-miologist whose work has centered on development and maintenance of Brazil's universal healthcare system. Along with his training in epidemiology, Dr De Negri has a specialty in emergency medicine and a PhD involving research focused on policy, planning, economics and health systems management. In addition to his other responsibilities, he serves as an expert on the right to development for the UN Human Rights Council. He spoke with MEDICC Review from his hometown in Porto Alegre.Dr José Ramón Acosta-Sariego is full professor of basic and preclinical scienc-es at the Medical University of Havana's Victoria de Girón Institute, where he also chairs the Scientifi c Research Ethics Committee. He serves as vice-chair of the Board of Directors of UNESCO's Latin American and Caribbean Bioethics Net-work (REDBioética) and in 2020, UNES-CO's Director-General appointed him to its 36-member International Bioethics Committee. Dr Acosta-Sariego has been academic coordinator for the bioethics master's degree program at the Univer-sity of Havana since its inception in 2006, is president of the Neuroethics Chapter of the Cuban Neurosciences Society and is a member of the Cuban National Bioeth-ics Committee.Dr Pastor Castell-Florit's career in public health spans work at local, na-tional and international levels. In 2016, he received PAHO's Award for Health Administration in the Americas, for "outstanding leadership and valuable contributions to the management and administration of the Cuban National Health System." He serves as presi-dent of Cuba's National Council of Sci-entific Societies in Health, as director of the National School of Public Health, and is a member of the Cuban Acad-emy of Sciences. He has published numerous books and articles on so-cial determinants of health and inter-sectoral actions to address them, and holds doctorates in science and the health sciences.Dr Jeanette Vega is well known in global health circles for her work in the areas of health equity, social determinants of health and health systems. She has served as Chile's Vice Minister of Health, and as director of the country's National Health Fund (FONASA). For fi ve years, she was also WHO Director of Equity and Social Determinants of Health. She currently sits on the 13-member Global Preparedness Monitoring Board (GPMB), co-chaired by H.E. Gro Harlem Brundt-land, Former Prime Minister of Norway and Former WHO Director-General; and Mr Elhadj As Sy, Chair, Kofi Annan Foun-dation Board, and Former Secretary-General, International Federation of Red Cross and Red Crescent Societies. An independent international monitoring and advocacy body, the GPMB prepared the seminal 2019 report on the state of global preparedness, A World at Risk.
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