Notes

Distinct renin/aldosterone activity information correlate along with kidney perform, natriuretic reply, decongestive ability as well as prospects within severe center failure.
Earlier menarche was more characteristic for abnormal uterine bleeding at puberty and later one - at hypomenstrual syndrome. Physical development of girls can be considered as a "marker" of their health status, an indicator of forecast for the formation of reproductive potential and fertility in the future.Violation of the formation of menstrual function in adolescent girls of the puberty is a widespread phenomenon, that is greatly affected with age-related aspects. Since the factors affecting the body will be forming the anthropometric and somatotypological indicators of the body of girls differently, it is therefore advisable to divide them according to narrow age categories 12-14 years, 14-15 years. And 16-18 years old. 288 adolescent females were examined, 58 of which with abnormal uterine bleeding were included in the main group, 230 actually healthy girls of the same age were included in the comparison group. General clinical, ultrasound, laboratory, anthropometric, somatotypological and statistical research methods were used. Analysis of the data obtained was carried out using the program "STATISTICA 5.5" using non-parametric methods for evaluating the results. The aim to predict the development of abnormal uterine bleeding using discriminant function, according to the age categories. Anthropometric, somatotypological and statistical research methods. After examination of girls of different age categories, we obtained results according to which for girls aged 14-15 in predicting the AUB pathognomonic indicators were Mateyko body mass fat component according to Mateyko, transverse lower pit size, circumference of the chest in a state of rest and in a state of maximum exhale, the distal epiphysis of the forearm, the ectomorphic component of the Mateyko according to Heath-Carter, the width of the distal epiphysis of the hip and the external conjugate. Girls of 16-18 years old have relevant indicators such as transverse lower pit size, body mass fat component according to Mateyko, chest circumference in a state of maximum exhale, thickness of the skin-fat fold under the shoulder, on the chest, on the abdomen and side, the width of the distal epiphysis of the femur. Thus, we have characterized the patterns of the occurrence of abnormal uterine bleeding for girls 14-15 y. and 16-18 y.e respectively.Preterm birth, in a long-term perspective, is a priority for medicine and public health, as it is directly associated with health index of the population. Georgian clinical management guidelines for preterm birth is based on non-Georgian experience, due to lack of population-based research in Georgia. For this purpose, it was implemented Cause-effect epidemiological study with the purpose on risk factors of preterm birth. Study based on 2018 Georgian Birth Registry (GBR) with registered 50468 childbirth cases, data was conducted for total Georgian single-fetus (n=49762) population according to known biomedical and behavior-related expositions based on a review of the scientific literature from 1999-2020. Target variable was divided into two sub-variables (dichotomy variable), according to which, pregnancy term of 258 days including was determined as preterm, while 259 and above was considered as timely. Study of risk factors of preterm birth was implemented using stages of backward selection modelling of analreterm birth. This process requires shared responsibility between medical personnel, pregnant woman and environment. Prevention should be ensured through effective use of medical technologies, formulation of interventions of different levels on behavior-related factors public awareness, education, active interventions.Today, modern medical practice proposes to abandon surgical methods for treating meniscus injuries and allows the use of more effective and modern technologies, including regenerative injection techniques. The aim of the study was to evaluate the effectiveness of L-PRP injections in the knee meniscus injury. The study was conducted on the basis of the Center for tissue and cell therapy of the State Institution «ITO NAMS of Ukraine» during 2017-2020. The study involved 120 patients who were divided into 2 groups for group 1 (n=58), the course of treatment consisted of 3 intra-articular injections of autologous PRP; for group 2 (n=62) - the course of treatment was 4-6 injections. The functional state of the patients was assessed based on the VAS, WOMAC, and the Oxford Knee Score (OKS) scale at the time of the visit, after 3 months, 12 months. and 2 years after completion of the course of injection therapy. After using regenerative injections, after 3 months there was an improvement on the WOMAC questionnaire ino a course of 3 injections (up to 1 year).The development of new technologies in medicine lead to creating an optimal treatment methods of cystic liver echinococcosis, based on minimally invasive technologies, such as percutaneous puncture-aspiration echinococcectomy (PAIR) under ultrasound (US) guidance. Aim of this study is to analyze and evaluate the efficiency of PAIR treatment. The study material included a retrospective analysis of 33 patients who underwent PAIR from December 2017 to December 2019. Of them, 25 (75%) patients with primary CLE, 8 (24%) patients with recurrent cystic liver echinococcosis. Cystic liver echinococcosis was staged according to WHO classification by US images. All patients pre- and postoperatively received therapy with Albendazole. The mean duration of surgery was 41 (30-70) min. Hospital stay times were ranged from 2 and 16 days (mean 4,8 days) in all patients. The conversion to laparotomy during the procedure was not necessary. Ademetionine Operation was finished in 3 cases due to developing anaphylactic shock during operation. There was no fatal outcome in any cases. One patient developed bilio-cystic communication, resolved spontaneously without additional treatment. The use of minimally invasive PAIR intervention followed by Albendazole therapy has a positive effect on reducing the patient's hospital stay.On October 2, 2020, by Novo Nordisk initiative, an expert council was held in Tbilisi, Georgia, dedicated to the problems of introducing innovative insulin therapy on the example of insulin degludek into the clinical practice. The council chaired by prof. R. Kurashvili included seven leading endocrinology experts in Georgia and a specialist in the field of pharmaco-economics from Russian Federation Prof. A. Kulikov. During the expert council, important scientific, clinical and economic emphases were made on the benefits of using insulin degludec associated with its unique structure and mechanism of action. Special emphasis was placed on the difficulty in managing children and adolescents with type 1 diabetes. The meeting provided compelling evidence that insulin degludec reduces the incidence of hypoglycemia and diabetic ketoacidosis, thereby contributing to overall health and the prevention of vascular complications in children and adolescents with diabetes. The members of the council resolved to petition the Georgian Ministry of Health to include insulin degludek in the state program for children and adolescents with diabetes.
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