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Heart problems throughout weight problems hypoventilation symptoms * An assessment prospective components as well as effects of treatments.
CONCLUSIONS PHTRBC is increasingly used by Emergency Medical Services, but guidelines on when to initiate transfusion are lacking. We identified the most commonly used transfusion criteria, and these findings may provide the basis for consensus-based pre-hospital transfusion protocols. © 2020 The Authors. Transfusion Medicine published by John Wiley & Sons Ltd on behalf of British Blood Transfusion Society.Ecosystem functions provided by forests are threatened by direct and indirect effects of global change drivers such as climate warming land use change, biological invasions, and shifting natural disturbance regimes. To develop resilience-based forest management, new tools and methods are needed to quantitatively estimate forest resilience to management and future natural disturbances. We propose a multi-dimensional evaluation of ecological resilience based on species functional response traits (e.g. functional response diversity and functional redundancy) and network properties of forested patches (e.g. connectivity, modularity, and centrality). Using a fragmented rural landscape in temperate south-eastern Canada as a reference landscape, we apply our multi-dimensional approach to evaluate two alternative management strategies at three levels of intensity (1) functional enrichment of current forest patches and (2) multi-species plantations in previously non-forested patches. Within each management strategy, p biodiversity-enhancing species (i.e. species that maximize functional diversity) mitigated drought effects equally well as planting with drought-tolerant species. Our multi-dimensional approach facilitates the characterisation at the landscape scale of forest resilience to disturbances using both functional diversity and network properties while accounting for the importance of response traits to future disturbances. The simulation approach we used can be applied to forest landscapes across different biomes for the evaluation and comparison of forest management initiatives to enhance resilience. This article is protected by copyright. All rights reserved.Reactive oxygen species (ROS) often injure intestinal epithelia that cause loss of damaged cells, which is mainly repaired by proliferation of intestinal stem cells (ISCs). To maintain the homeostatic state, coordination of sensing of the ROS injury and the subsequent epithelial cell loss with the replenishment by cell renewal is crucial. However, little is known about how gut epithelial cells initiate regenerative responses against ROS to maintain the tissue integrity. Here, we carried out a genome-wide screen, by which we identify immunoglobulin superfamily beaten path Ib (beat-Ib) as an essential gene for provoking ISC proliferation against ROS in Drosophila intestine. RG108 research buy Interestingly, the beat-Ib function is required in differentiated enterocytes, the main targeted cells by ROS in the intestinal tract, but is dispensable in the stem cells. Moreover, beat-Ib is not involved in enterocyte apoptosis at ROS injury. These findings indicate the essential role of beat-Ib in Drosophila midgut enterocytes for initiating the non-cell-autonomous induction of ISC division in response to environmental ROS stresses. © 2020 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.Changes in modulation rate are important cues for parsing acoustic signals, such as speech. We parametrically controlled modulation rate via the correlation coefficient (r) of amplitude spectra across fixed frequency channels between adjacent time frames broadband modulation spectra are biased toward slow modulate rates with increasing r, and vice versa. By concatenating segments with different r, acoustic changes of various directions (e.g., changes from low to high correlation coefficients, that is, random-to-correlated or vice versa) and sizes (e.g., changes from low to high or from medium to high correlation coefficients) can be obtained. Participants listened to sound blocks and detected changes in correlation while MEG was recorded. Evoked responses to changes in correlation demonstrated (a) an asymmetric representation of change direction random-to-correlated changes produced a prominent evoked field around 180 ms, while correlated-to-random changes evoked an earlier response with peaks at around 70 and 120 ms, whose topographies resemble those of the canonical P50m and N100m responses, respectively, and (b) a highly non-linear representation of correlation structure, whereby even small changes involving segments with a high correlation coefficient were much more salient than relatively large changes that did not involve segments with high correlation coefficients. Induced responses revealed phase tracking in the delta and theta frequency bands for the high correlation stimuli. The results confirm a high sensitivity for low modulation rates in human auditory cortex, both in terms of their representation and their segregation from other modulation rates. © 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.INTRODUCTION AND AIMS People who use substances have a high prevalence of modifiable chronic disease health risk behaviours. Preventive care to address such risks has not traditionally been provided during substance use treatment. This study aimed to assess clinicians' attitudes towards preventive care and their association with care provision. DESIGN AND METHODS A cross-sectional study utilising computer-assisted telephone interviews was undertaken with clinicians (n = 54) of community-based substance use treatment services in one health district, Australia. Clinicians indicated their agreement with 10 attitudinal statements regarding their perceived role and self-efficacy in providing preventive care and perceptions of client interest in modifying behaviours. Logistic regression analyses examined the association between clinician attitudinal items and self-reported care provision. RESULTS Fifty-four clinicians (74%) agreed to participate. The most positive attitudes were preventive care being part of their role (100%), and they have the knowledge and skills to provide preventive care (100%). The least favourable attitude was clients were interested in changing their health risk behaviours (60%). Clinicians who reported that preventive care left little time to undertake acute care were more likely to assess for smoking (OR 8.06 [95% CI 1.31, 49.46]) and less likely to provide brief advice for all risks combined (OR 0.11 [95% CI 0.02, 0.63]). DISCUSSION AND CONCLUSIONS Overall, clinicians reported positive attitudes regarding the preventive care provision for modifiable health risk behaviours in substance use treatment settings. Further research is required to investigate why, despite such positive attitudes, clinicians in substance use treatment settings do not routinely provide preventive care. © 2020 Australasian Professional Society on Alcohol and other Drugs.
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