Notes

While seeking bad targets for good motives causes it to be worse: a new sociable worth way of performance-avoidance goal search.
Curcumin is a lipophilic natural product extracted from turmeric and commonly used as a dietary spice. Being multi-functional, curcumin has been proposed in the prevention and treatment of a broad spectrum of diseases. However, due to unsatisfactory aqueous solubility and hence low bioavailability, clinical application of curcumin has been greatly restrained. To break these limitations, biocompatible nanoformulation, such as liposomes, nanoparticles, micelles, nanoemulsions and conjugates has been employed as alternatives to improve in vivo delivery of curcumin. In this scenario, in order to enhance bioavailability of curcumin, the choice of effective molecules as facilitators is of prominence. In this review, we focus on functional biocompatible materials, including polymers, protein molecules, polysaccharide, surface stabilizers and phospholipid complexes, and decipher their potential applications as how they assist to promote medicinal performance of curcumin.Recent studies indicated that the toxicity of heavy metal ions caused a series of environmental, food, and human health problems. Chemical ionochromic sensors are crucial for detecting these toxicity ions. Incorporating organic ligands into π-conjugated polymers made them receptors for metal ions, resulting in an ionochromism phenomenon, which is promising to develop chemosensors for metal ions. This review highlights the recent advances in π-conjugated polymers with ionochromism to metal ions, which may guide rational structural design and evaluation of chemosensors.In order to improve the stability of high voltage electrolyte for 5 V-level LiNi0.5Mn1.5O4 cathode material, adiponitrile (ADN) with high oxidation stability was selected as the main solvent, meanwhile, 2% fluoroethylene carbonate (FEC) as the additive with good film forming effect was also used. And then, the effect of 2 mol L-1 LiBF4-GBL/ADN+2% FEC on the electrochemical performance of LiNi0.5Mn1.5O4 was explored at room temperature. The electrolyte system containing FEC can improve the cycle stability of the battery. BMS-1 inhibitor At 1 C rate, the cycle capacity retention rate can reach 83% after 100 cycles, while the capacity retention rate of the electrolyte system without FEC and the ordinary commercial electrolyte system is only 77 and 68%, respectively. Besides, the rate performance of the battery with the addition of FEC also shows excellent performance, however, this kind of advantage is not obvious under the conditon of large rate. In addition, under the conditon of the synergistic effect between adiponitrile and fluoroethylene carbonate, the high-voltage electrolyte exhibits the good compatibility and lithium reversibility in the full cell with Li4Ti5O12 as the negative electrode.In this study, h-BN@PDA@TiO2 hybrid nanoparticles were prepared and used as functional fillers to prepare PVA nanocomposites, and the effects of hybrid particles on PVA thermal conductivity and flame retardant properties were studied. The results showed that hybrid particles could significantly improve the thermal conductivity and flame retardant performance of PVA composites, and effectively inhibit the release of toxic gases such as combustible pyrolysis products and CO, which enhanced the fire safety of PVA composites. When the addition amount of hybrid particles is 5 wt%, the thermal conductivity of PVA composites is 239.1% higher than that of the pure PVA and the corresponding temperature of PVA composites with a mass loss of 5 wt% was 16.2°C higher than that of the pure PVA. This is due to the barrier effect of h-BN and the protective effect of dense carbon layer catalyzed by TiO2.Polyphenol, characterized by various phenolic rings in the chemical structure and an abundance in nature, can be extracted from vegetables, grains, chocolates, fruits, tea, legumes, and seeds, among other sources. Tannic acid (TA), a classical polyphenol with a specific chemical structure, has been widely used in biomedicine because of its outstanding biocompatibility and antibacterial and antioxidant properties. TA has tunable interactions with various materials that are widely distributed in the body, such as proteins, polysaccharides, and glycoproteins, through multimodes including hydrogen bonding, hydrophobic interactions, and charge interactions, assisting TA as important building blocks in the supramolecular self-assembled materials. This review summarizes the recent immense progress in supramolecular self-assembled materials using TA as building blocks to generate different materials such as hydrogels, nanoparticles/microparticles, hollow capsules, and coating films, with enormous potential medical applications including drug delivery, tumor diagnosis and treatment, bone tissue engineering, biofunctional membrane material, and the treatment of certain diseases. Furthermore, we discuss the challenges and developmental prospects of supramolecular self-assembly nanomaterials based on TA.Alkylphospholipids (APLs) have elicited great interest as antitumor agents due to their unique mode of action on cell membranes. However, their clinical applications have been limited so far by high hemolytic activity. Recently, cationic prodrugs of erufosine, a most promising APL, have been shown to mediate efficient intracellular gene delivery, while preserving the antiproliferative properties of the parent APL. Here, cationic prodrugs of the two APLs that are currently used in the clinic, miltefosine, and perifosine, are investigated and compared to the erufosine prodrugs. Their synthesis, stability, gene delivery and self-assembly properties, and hemolytic activity are discussed in detail. Finally, the potential of the pro-miltefosine and pro-perifosine compounds M E12 and P E12 in combined antitumor therapy is demonstrated using pUNO1-hTRAIL, a plasmid DNA encoding TRAIL, a member of the TNF superfamily. With these pro-APL compounds, we provide a proof of concept for a new promising strategy for cancer therapy combining gene therapy and APL-based chemotherapy.Carbon quantum dots (CQDs) were manufactured from citric acid and urea in a gram-scale synthesis with a controlled size range between 1. 5 and 23.8 nm. The size control was realized by varying volume of the precursor solution in a hydrothermal synthesis method. The prepared CQDs were investigated using electrochemiluminescence (ECL) spectroscopy at interfaces of their electrode films and electrolyte solution containing coreactants rather than conventional optoelectronic tests, providing an in-depth analysis of light-emission mechanisms of the so-called half-cells. ECL from the CQD films with TPrA and K2S2O8 as coreactants provided information on the stability of the CQD radicals in the films. It was discovered that CQD•- has a powerful electron donating nature to sulfate radical to generate ECL at a relative efficiency of 96% to the Ru(bpy)3Cl2/K2S2O8 coreactant system, indicating a strong performance in light emitting applications. The smaller the CQD particle sizes, the higher the ECL efficiency of the film interface, most likely due to the increased presence of surface states per mass of CQDs.
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