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Patterns associated with wasting among expectant and also lactating females inside Uganda, 2015-2018: evaluation involving Nutrition detective info.
Qualitative findings also revealed that students found PBL enjoyable. According to PBL students, searching for information and writing reports were among the features of the PBL contributing to their learning the most.
The COVID-19 pandemic necessitates collaborative teamwork by all healthcare providers including pharmacists. Since Pharmacy and Pharm. D students represent the future pharmacists, it is necessary to ensure that they have a good awareness about COVID-19 or any other pandemic that could happen in the future.

The study aim was to evaluate Pharmacy and Pharm.D students' knowledge and information needs about COVID-19.

A cross-sectional web-based design survey was used to assess socio-demographics and knowledge about COVID-19 amongst Pharmacy and Pharm. D students. After being validated, the questionnaire was formatted into Google forms and distributed amongst undergraduate Pharmacy and Pharm. D students in accredited Universities in Jordan.

A total of 860 Pharmacy and Pharm.D students completed the questionnaire. Results revealed moderate students' knowledge about COVID-19 (mean knowledge score was 5.6 out of 10). Students had high correct response rates in questions asking about transmission method, treatOVID-19, with an emphasis on the need for more active role by the universities to achieve this goal.Root nutation indicates the behavior that roots grow in a waving and skewing way due to unequal growth rates on different sides. Although a few developmental and environmental factors have been reported, genetic pathways mediating this process are obscure. We report here that the Arabidopsis CrRLK1L family member FERONIA (FER) is critical for root nutation. Functional loss of FER resulted in enhanced root waviness on tilted plates or roots forming anti-clockwise coils on horizontal plates. Suppressing polar auxin transport, either by pharmacological treatment or by introducing mutations at PIN-FORMED2 (PIN2) or AUXIN RESISTANT1 (AUX1), suppressed the asymmetric root growth (ARG) in fer-4, a null mutant of FER, indicating that FER suppression of ARG depends on polar auxin transport. We further showed by pharmacological treatments that dynamic microtubule organization and Ca2+ signaling are both critical for FER-mediated ARG. Results presented here demonstrate a key role of FER in mediating root nutating growth, through PIN2- and AUX1-mediated auxin transport, through dynamic microtubule organization, and through Ca2+ signaling.We read with interest the study by Zhang et al1 where they explored the association between lifestyle habits and the severity of non-alcoholic fatty liver disease (NAFLD) in different Asian regions. The authors found that unhealthy lifestyles and physical inactivity were common across all the regions and that patients with a liver stiffness less then 10 kPa were more likely to report participating in some vigorous activity. The focus on physical activity besides weight control is also timely as up to 40% of the NAFLD population are not obese.2.
Tau hyperphosphorylation is involved in the progression of Alzheimer's disease (AD). In the present study, we aimed to evaluate the role of linc00507 with respect to modulating Tau phosphorylation in ab AD animal and an Aβ42-SH-SY5Y cell model.

Aβ precursor protein (APP)/PS transgenic mice and Aβ42-SH-SY5Y cell model were used to investigate the role of linc00507 in AD. A quantitative real-time polymerase chain reaction evaluated the RNA expression of linc00507, miR-181c-5p and microtubule-associated protein tau (MAPT)/tau-tubulin kinase-1 (TTBK1). The interactions between the genes were investigated through changes in one gene expression by regulating another gene in cells and, in addition, correlation assays were performed in mice. BMS986278 Western blot assays examined the protein expression of MAPT/TTBK1, phosphorylation of tau and signaling proteins P25/P35/GSK3β in response to the regulation of linc00507, miR-181c-5p and MAPT/TTBK1 in cells and also in mice.

linc00507 was significantly elevated in hippocampus, and cerebral cortex of APP/PS transgenic mice and AD-like SH-SY5Y cells. It could bind miR-181c-5p and thereby regulate the expression of microtubule-associated protein Tau (MAPT) and tau-tubulin kinase-1 (TTBK1) as a competitive endogenous RNA (ceRNA). MAPT (encoding the tau protein) and TTBK1 (encoding a tau kinase) were identified as direct target genes of miR-181c-5p. Furthermore, linc00507 mediated tau protein hyperphosphorylation by the activation of the P25/P35/GSK3β signaling pathway through regulating MAPT/TTBK1 by sponging miR-181c-5p.

The findings of the present highlight the regulatory role of linc00507 in tau phosphorylation miR-181c-5p as ceRNA of MAPT/TTBK1 in vitro and in vivo, providing a basis for novel diagnostic and treatment strategies for AD.
The findings of the present highlight the regulatory role of linc00507 in tau phosphorylation miR-181c-5p as ceRNA of MAPT/TTBK1 in vitro and in vivo, providing a basis for novel diagnostic and treatment strategies for AD.Given the present need for biochemistry and molecular biology educators to transform their courses into an online format, novel methods aimed at promoting student learning and engagement must be considered. Herein, we describe the integration of graphical systems modeling as a tool for introducing biochemistry to secondary-level students. We propose the use of graphic technologies as a way for students to create systems models that describe phenomena of life, such as lactation. Through these endeavors, educators can provide a virtual format for students to continue learning and completing assignments.Neuroinflammation is believed to play a primary role in the pathogenesis of most neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and schizophrenia. Currently, suitable in vitro neuroinflammation models for studying cellular interactions and inflammatory mechanisms at the neurovascular unit are still scarce. In this study, we established an experimentally flexible tri-culture neuroinflammation model combining murine microglial cells (N11), mouse neuroblastoma Nuro2A cell lines and brain microvascular endothelial MVEC(B3) cells in a transwell co-culture system stimulated with lipopolysaccharides. Neuroinflammation was induced in this tri-culture model as manifested by activated N11 cells via toll-like receptor 4, resulting in increased release of proinflammatory mediators (nitric oxide, interleukin-6 and tumour necrosis factor-α) through the activation of nuclear factor-κB signalling pathway. The released inflammatory cytokines from N11 in turn, damaged the tight junction in microvascular endothelial MVEC(B3) cells, increased permeability of endothelial barrier, and induced tau phosphorylation and up-regulated caspase-3 expression in mouse neuroblastoma Nuro2A cell lines, leading to neuroinflammation injury.
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