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Designing innovative (nano)detection platforms, respecting their low-cost and fabrication simplicity, capable to chemically detect multiple target analytes by employing the same engineered device, is still a great challenge in the multiplexed biosensor development. In this scientific context, in the current manuscript, we exploit the low-cost plasmonic calligraphy as a versatile approach to directly draw continuous plasmonic lines on Whatman paper using a regular ballpoint pen successively filled with two different anisotropic nanoparticles shapes (gold bipyramids-AuBPs and gold nanorods-AuNRs) as colloidal inks. After the efficient immobilization of the positively-charged AuBPs and AuNRs onto the paper fibres, proved by Scanning Electron Microscopy (SEM) investigations, the specificity of our as-calligraphed-paper platform is ensured by coating the selected lines with a thin layer of anionic poly(styrene sulfonate) polyelectrolyte, creating, consequently, a well-defined plasmonic array of charge-selective regions. Finally, the functionality of the well-isolated and as-miniaturized active plasmonic array is, subsequently, tested using the anionic Rose-Bengal and cationic Rhodamine 6G target analytes and proved by complementary dual optical "ON/OFF Switch" sensing (i.e. Surface-enhanced Raman Scattering sensing/metal-enhanced fluorescence sensing) onto the same plasmonic line, developing thus a simple multiplexed plasmonic array platform, which could further facilitate the well-desired biomarker detection in complex mixtures.We propose herein a unique mechanism of generating tunable surface charges in a metal-dielectric Janus nanopore for the development of nanofluidic ion diode, wherein an uncharged metallic nanochannel is in serial connection with a dielectric nanopore of fixed surface charge. In response to an external electric field supplied by two probes located on both sides of the asymmetric Janus nanopore, the metallic portion of the nanochannel is electrochemically polarized, so that a critical junction is formed between regions with an enriched concentration of positive and negative ions in the bulk electrolyte adjacent to the conducting wall. The combined action of the field-induced bipolar induced double layer and the native unipolar double layer full of cations within the negatively-charged dielectric nanopore leads to a voltage-controllable heterogenous volumetric charge distribution. The electrochemical transport of field-induced counterions along the nanopore length direction creates an internal zone of ion enrichd-charge electrokinetic phenomena for a high degree of freedom ion current control.This study proposes negative capacitance vacuum channel transistors. The proposed negative capacitance vacuum channel transistors in which a ferroelectric capacitor is connected in series to the gate of the vacuum channel transistors have the following two advantages first, adding a ferroelectric capacitor in series with a gate capacitor makes the turn-on voltage lower and on-off transition steeper without causing hysteresis effects. Second, the capacitance matching between a ferroelectric capacitor and a vacuum channel transistor becomes simplified because the capacitance of a vacuum channel transistor as seen from a ferroelectric capacitor is constant.Ionic liquids (ILs) are increasingly used in elastomer technology due to unique physico-chemical properties, which are stable at the temperature of preparation and during processing of rubber compounds. The latest IL application concept is supported ionic liquid-phase (SILP) materials, where an IL film is immobilized on the solid phase. The main aim of this work was studying the influence of IL immobilized on the surface of solid supports, such as silica and carbon black, on the vulcanization process, mechanical properties, and thermal behavior of ethylene-propylene-diene (EPDM) elastomer. Application of the SILP materials enabled the control of EPDM vulcanization without deterioration of the crosslink density, damping properties, thermal stability, and resistance of the vulcanizates to thermo-oxidative aging. Slight improvements in the tensile strength and hardness of the vulcanizates were observed.Exposure to Legionella spp. contaminated aerosols in hotel settings confers risk for travel-associated Legionnaire's disease (TALD). In this study, we investigated the prevalence of Legionella contamination and its molecular diversity in hotels and resorts across Israel. The study was comprised of a convenience sample of water systems from 168 hotels and resorts countrywide, routinely inspected between March 2015 and February 2017. Torkinib supplier Isolation and quantitation of Legionella were performed in a water laboratory using the ISO 11731 method. The distribution of Legionella isolates was analyzed according to geography and source. The genetic diversity of a subset of isolates was analyzed by sequence-based typing (SBT) at the National Reference Laboratory for Legionella and compared to the national database. Out of 2830 samples tested, 470 (17%) obtained from 102 different premises (60% of hotels) were positive for Legionella spp. In 230 samples (49% of all positive, 8% of total samples), accounting for 37% of hotels, Legionella spp. counts exceeded the regulatory threshold of 1000 CFU/L. The most frequently contaminated water sources were cooling towers (38%), followed by faucets, hot tubs, water lines, and storage tanks (14%-17% each). Furthermore, 32% and 17% of samples obtained from cooling towers and hot tubs, respectively, exceeded the regulatory thresholds. SBT was performed on 78 strains and revealed 27 different sequence types (STs), including two novel STs. The most prevalent STs found were ST1 (26%), ST87 (10%), ST93 (6%), and ST461 and ST1516 (5% each). Several L. pneumophila STs were found to be limited to certain geographical regions. This is the first study to investigate the prevalence and diversity of Legionella in hotels and resorts in Israel during non-outbreak environmental inspections. These findings will inform risk assessment, surveillance, and control measures of TALD.
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