Notes

A manuscript Spider-Inspired Rotary-Rolling Diaphragm Actuator with Straight line Torque Feature and Hardware Efficiency.
Mortality prediction is an important task to achieve smart healthcare, especially for the management of intensive care unit. It can provide a reference for doctors to quickly predict the course of disease and customize early intervention programs for the patients in need. With the development of the electronic medical records, deep learning methods are introduced to deal with the prediction task. In the electronic medical records, clinical notes always contain rich and diverse medical information, including the clinical histories and reports during admission. Mortality prediction methods mostly rely on the temporal events such as medical examinations and ignore the related reports and history information in the clinical notes. Disodium Cromoglycate concentration We hope that we can utilize both temporal events and clinical notes information to get better mortality prediction results.

We propose a multimodal temporal-clinical note network to model both temporal and clinical notes. Specifically, the clinical text are further processed for difthe MIMIC-III dataset. Contributions of different clinical note sections were uncovered by visualization methods. Our work demonstrates that the introduction of the medical history related information can improve the performance of the mortality prediction. Using label aware convolutional neural networks can further improve the results.
Adjuvant systemic breast cancer treatment improves disease specific outcomes, but also presents with cardiac toxicity. In this post-hoc exploratory analysis of the OptiTrain trial, the effects of exercise on cardiotoxicity were monitored by assessing fitness and biomarkers over the intervention and into survivorship. Methods; Women starting chemotherapy were randomized to 16-weeks of resistance and high-intensity interval training (RT-HIIT), moderate-intensity aerobic and high-intensity interval training (AT-HIIT), or usual care (UC). Outcome measures included plasma troponin-T (cTnT), Nt-pro-BNP and peak oxygen uptake (VO
), assessed at baseline, post-intervention, and at 1- and 2-years.

For this per-protocol analysis, 88 women met criteria for inclusion. Plasma cTnT increased in all groups post-intervention. At the 1-year follow-up, Nt-pro-BNP was lower in the exercise groups compared to UC. At 2-years there was a drop in VO
for patients with high cTnT and Nt-pro-BNP. Fewer patients in the RT-HIIT group fulfilled biomarker risk criteria compared to UC (OR 0.200; 95% CI = 0.055-0.734).

In this cohort, high-intensity exercise was associated with lower levels of NT-proBNP 1-year post-baseline, but not with cTnT directly after treatment completion. This may, together with the preserved VO
in patients with low levels of biomarkers, indicate a long-term cardioprotective effect of exercise.

Clinicaltrials. govNCT02522260 , Registered 13th of august 2015 - Retrospectively Registered.
Clinicaltrials. govNCT02522260 , Registered 13th of august 2015 - Retrospectively Registered.Our recent paper ( https//doi.org/10.1186/s41073-020-00096-x ) reported that 43% of reviewer comment sets (n=1491) shared with authors contained at least one unprofessional comment or an incomplete, inaccurate of unsubstantiated critique (IIUC). Publication of this work sparked an online (i.e., Twitter, Instagram, Facebook, and Reddit) conversation surrounding professionalism in peer review. We collected and analyzed these social media comments as they offered real-time responses to our work and provided insight into the views held by commenters and potential peer-reviewers that would be difficult to quantify using existing empirical tools (96 comments from July 24th to September 3rd, 2020). Overall, 75% of comments were positive, of which 59% were supportive and 16% shared similar personal experiences. However, a subset of negative comments emerged (22% of comments were negative and 6% were an unsubstantiated critique of the methodology), that provided potential insight into the reasons underlying unprofessiit that priority should be given to repairing the negative cultural zeitgeist that exists in peer-review.
The current research-care separation was introduced to protect patients from explanatory studies designed to gain knowledge for future patients. Care trials are all-inclusive pragmatic trials integrated into medical practice, with no extra tests, risks, or cost, and have been designed to guide practice under uncertainty in the best medical interest of the patient.

Patients need a distinction between validated care, previously verified to provide better outcomes, and promising but unvalidated care, which may include unnecessary or even harmful interventions. While validated care can be practiced normally, unvalidated care should only be offered within declared pragmatic care research, designed to protect patients from harm. The validated/unvalidated care distinction is normative, necessary to the ethics of medical practice. Care trials, which mark the distinction and allow the tentative use of promising interventions necessarily involve patients, and thus the design and conduct of pragmatic care research mknown benefits in practice; and eventually (iii) a verdict regarding optimal care.
To report the occurrence of tophaceous gout in the cervical spine and to review the literature on spinal gout.

This report details the occurrence of a large and clinically significant finding of tophaceous gout in the atlantoaxial joint of the cervical spine in an 82-year-old Caucasian man with a 40-year history of crystal-proven gout and a 3-month history of new-onset progressive myelopathy. The patient's American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria score was 15.0.

Spinal gout is more common than previously thought, and it should be considered in patients who present with symptoms of myelopathy. Diagnosis can be made without a tissue sample of the affected joint(s) with tools like the ACR/EULAR criteria and the use of the "diagnostic clinical rule" for determining the likelihood of gout. Early conservative management with neck immobilization and medical management can avoid the need for surgical intervention.
Spinal gout is more common than previously thought, and it should be considered in patients who present with symptoms of myelopathy.
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