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Inhibition of progesterone receptor membrane component-1 exasperates neonatal hypoxic-ischemic cerebral harm within guy these animals.
This is significant as it opens the possibility for 1O2 detection methods which do not require a traditional "photodetector" and associated optics, simplifying the instrumentation over existing fluorescence detection methods and potentially even lowering the cost.The facet of optical fibers coated with nanostructures enables the development of ultraminiature and sensitive (bio)chemical sensors. The sensors reported until now lack specificity, and the fabrication methods offer poor reproducibility. Here, we demonstrate that by transforming the facet of conventional multimode optical fibers onto plasmon resonance energy transfer antenna surfaces, the specificity issues may be overcome. To do so, a low-cost chemical approach was developed to immobilize gold nanoparticles on the optical fiber facet in a reproducible and controlled manner. Our nanosensors are highly selective as plasmon resonance energy transfer is a nanospectroscopic effect that only occurs when the resonance wavelength of the nanoparticles matches that of the target parameter. As an example, we demonstrate the selective detection of picomolar concentrations of copper ions in water. Our sensor is 1000 times more sensitive than the state-of-the-art technologies. An additional advantage of our nanosensors is their simple interrogation; it comprises of a low-power light-emitting diode, a multimode optical fiber coupler, and a miniature spectrometer. We believe that the plasmon resonance energy transfer-based fiber-optic platform reported here may pave the way for the development of a new generation of ultraminiature, portable, and hypersensitive and selective (bio)chemical sensors.BACKGROUND Ingestion of metallic foreign bodies (MFBs) is a frequent occurrence in children and is commonly diagnosed via X-rays. In recent years, the handheld metal detector (HMD) has been increasingly adopted by several paediatric hospitals as it is considered an effective and accurate diagnostic tool that avoids exposure to ionizing radiations. Sensitivity of HMD has been reported high (99.4%) in case of coin ingestion, but significantly lower (46%) when considering the ingestion of other types of MFBs. METHODS We tested the effectiveness of the HMD in diagnosing ingested MFBs in children less than 14 years of age, in our Paediatric Emergency Department (PED). We prospectively evaluated all cases of MFBs ingestion that presented at the PED of our hospital from March 2015 to July 2017. RESULTS 98 patients were included. The overall sensitivity was 63.2% (79.5% for coins, 25.5% for batteries and 56% for other objects) while the specificity was 95%. The HMD could have replaced the X-Ray examination only if a MFB was detected below the xyphoid process. CONCLUSIONS Based on our findings, a negative result of HMD is not sufficient to exclude an ingestion of MFBs. Therefore, in case of an evocative history and depending on type and size of the foreign body, a radiological investigation is still necessary.BACKGROUND Fetal gender is considered as one of significant predictors of pregnancy and perinatal outcome. Aim - To assess impact of fetal gender on perinatal outcome. METHODS Present observational study was conducted in Obstetrics and Gynecology department of rural tertiary center of Northern India over one year (January-December 2018) on all randomly selected antenatal women at gestation ≥28 weeks, delivering by any route (Cesarean/Vaginal) and fulfilling inclusion criteria were enrolled. Immediately after delivery, neonatal birth weight was measured using table top beam weighing scale. Apgar scores at 1- and 5-minutes, Neonatal Intensive Care Unit admission, neonatal complications were assessed by pediatrician. Adverse perinatal outcome including neonatal morbidities (prematurity, neonatal intensive care unit admission, neonatal complications) and perinatal mortality were compared between two genders. Statistical analysis was done using SPSS 22 version software. RESULTS Of 3,085 delivered neonates, 1,450(47%) were females, 1,633(52.9%) males and two (0.06%) had ambiguous genitalia, hence excluded. Mean±SD for neonatal birth weight for males was 2.77±0.540 Kg and females 2.65±0.506 Kg (p=.0000). Target Protein Ligand chemical 1- and 5-minutes Apgar scores for male neonate were 6.81±1.565, 8.51±1.841and for females 6.98±1.184, 8.70±1.383 respectively (p=0.001). NICU admission rate, need for oxygen and intubation, complications were significantly higher for male neonates (p0.05). CONCLUSIONS Male neonates had higher birth weight, but adverse perinatal outcome as compared to females.INTRODUCTION Since its diffusion in the 1990s, the Internet has developed into a fully integrated component of the lives of teenagers across the globe. As use of the Internet by underage youth has evolved and increased over the past decades, concerns about how technology may contribute to minors becoming victims of online sex crimes, including online grooming, have heightened. The present literature review contributes to the existing knowledge base regarding the epidemiology of the online grooming process, exploring key themes and issues arising in this area. EVIDENCE ACQUISITION We conducted a review of the current literature by an initial database research of papers published since 1990. Three independent reviewers selected relevant articles, initially based on title and abstract analysis, then by full text in order to make a final determination. After the final selection, a total of 37 articles were reviewed. EVIDENCE SYNTHESIS The articles reviewed report highly heterogenous results with regards to epidemiological data, estimating a prevalence of the online grooming phenomenon between 9% and 19%. Factors influencing minors' risk of online grooming included increasing age, gender, sexual minority orientation, diagnosis of mental disease, conflictual relationships with parents and risk-taking behaviors (eg. chat room and social networking site use). CONCLUSIONS Although the true prevalence of online grooming is not available, it is a significant issue among minors. It is thus important to educate youth on responsible internet use, starting at the earliest age and continuing during adolescence.
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