Notes

[Application associated with Animations stamping technology below three-dimensional renovation within mandibular reconstruction].
Among the various members of the mitogen-activated protein kinase (MAPK) family, p38 MAPK subgroup is the most involved in airway and lung inflammation underlying asthma and chronic obstructive pulmonary disease (COPD). In particular, several environmental agents including aeroallergens, cigarette smoke, airborne pollutants, viral and bacterial pathogens activate the p38α isoform which in turn up-regulates the expression of multiple proinflammatory cytokines and chemokines, as well as the production of some fibrogenic factors. Therefore, p38 MAPK-induced bronchial inflammation and remodelling significantly contribute to the development, persistence and amplification of airflow limitation, which is the hallmark of asthma and COPD. Such advances in our understanding of p38 role in the pathobiology of the above widespread, chronic obstructive respiratory diseases, have led to consider p38 MAPK as a suitable molecular target for novel treatment strategies. Indeed, many studies have been carried out in both animal and clinical settings, with the aim of evaluating the potential therapeutic effects of p38 MAPK inhibitors in both asthma and COPD.
To determine the preferred type of intraocular lens (IOL) that ophthalmologists would choose for themselves in case of cataract surgery.

Prospective convenience questionnaire study.

We developed an electronic survey with seven (7) questions, combining multiple and open options. The following categories were established monofocal (MonoIOL) without monovision (MonoIOL-SM) and with monovision (MonoIOL-CM) and multifocal (MultiIOL) that could be either a bifocal (MultiIOL-B), trifocal (MultiIOL-T) or extended focus (MultiIOL-E). The link for the survey was sent to ophthalmologists from Latin America and Spain through different ways. The 1209 responses were analyzed statistically.

We received 1209 responses from 14 countries. The average age was 47.977 years (SD 11.711 years). Gender distribution was 839 males (72.8%) and 313 females (27.2%). Overall preference was MonoIOL-SM 23.90% (289), MonoIOL-CM 12.16% (147), MultiIOL-B 4.63% (56), MultiIOL-T 34.99% (423), MultiIOL-E 15.22% (110), and unsure 9.10% (11elves as anterior segment specialists compared to posterior segment specialists.
We conducted cross-sectional examinations to determine the frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the pathogenesis of PRS by using spectral-domain optical coherence tomography (SD-OCT).

In 1516 cases involving glaucoma and suspected glaucoma, we retrospectively reviewed the disc and macular volume scans obtained by SD-OCT and categorized PRS into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch's membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.

The total frequency of PRS was 1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer 30.9%, ganglion cell layer 21.8%, inner plexiform layer 7.3%). However, in the ahead group, PRS was detected in the outer land axial length elongation. Careful follow-up is required to assess the development of PRS in glaucoma suspects. The pathogenesis of PRS has been elucidated to some degree by classifying the morphological condition of the PRS and BMO.
To analyze the real-life clinical outcome of a single dexamethasone implant (DEX) injection in the treatment of persistent diabetic macular edema (DME) after anti-vascular endothelial growth factor (anti-VEGF) agents in a sample of the Jordanian population.

An observational case study design that involved a retrospective chart review analysis in a tertiary hospital in Amman, Jordan. GW0742 clinical trial Patients who showed persistent DME after receiving at least six doses of anti-VEGF agents for DME treatment were included.

The study population consisted of 72 participants (29 females, 43 males) having an average age of 66 years. All patients had best-corrected visual acuity (BCVA) less than 0.7 (6/9) and SD-OCT documented center-involved DME. The study results showed that the average baseline BCVA improved from 0.205±0.1 before DEX injection to 0.358±0.1 at 3 months post-injection (p<0.0001). The central mean thickness (CMT) showed significant improvement also (539.347±132.402 to 379.041±99.430, p<0.0001). There was hortage of intravitreal injections, which occurs frequently at our center, a single DEX injection may be utilized as an effective DME therapy. Further research is mandated to identify clinical response in a larger sample and more frequent injections.
To determine the percentage of eyes with corneal astigmatic power stability and mean corneal keratometric power at 6-month post-pterygium excision, and to identify the time, and the associated factors, required to achieve stability.

This prospective observational study enrolled patients undergoing pterygium excision. Patients were evaluated for baseline characteristics and keratometric data before and every month after pterygium excision for six months using IOL Master 500
(Carl Zeiss, Meditec). Clinically stable corneal astigmatic power and keratometric power were, respectively, defined as changes in these parameters of less than 0.25 and 0.27 diopters after two consecutive visits. Time to corneal astigmatic and keratometric power stability, as well as factors associated with the stability, were analyzed.

Forty percent and 73.3% of eyes, respectively, demonstrated corneal astigmatic and corneal keratometric stability at six months post-operation. Within three months of reaching initial stability, theed a longer time for corneal astigmatic stability. It is recommended that keratometric stability be achieved for at least three months before commencing with additional procedures.
To explore ophthalmologists' preventive practices, and their perceived seriousness and perceived risk of transmission of coronavirus disease 2019 (COVID-19).

In a cross-sectional study, a semi-structured questionnaire was distributed online among ophthalmologists. Questions about COVID-19 infection, perceived seriousness, perceived risk of transmission, and recommended COVID-19 preventive practices were asked. Based on the adoption of a preventive measure and its frequency, a maximum preventive score of 25 was computed.

Among 126 respondents, the mean±SD age was 45.3±10.9 years, and 57.9% worked in a tertiary care hospital. Regarding preventive practices, 96.8% of ophthalmologists wore face masks, 89.6% avoided talking during the slit lamp examination, and 72.2% wore gloves during the ophthalmic examination. Availability of plastic barriers and regular disinfection of slit lamps were reported by 78.6% and 43.7% of ophthalmologists, respectively. The mean preventive score increased with increasing age (
=0.
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