Notes

Sericin cocoon bio-compatibilizer with regard to reactive blending associated with polycarbonate cassava starchy foods.
The alar base width, alar width, and alar curvature width increased by 1.214, 0.932, and 0.987 mm, respectively. The average volumetric change was 993.33 mm3, and the amount of increase relative to the average initial volume was 2.96%. Conclusions The majority of soft tissue landmarks around the nasal region show significant positional changes after MARPE in adults. The nose tends to widen and move forward and downward. The post-treatment nasal volume may also exhibit a significant increase relative to the initial volume. Clinicians should thoroughly explain the anticipated changes to patients before MARPE initiation. © 2020 The Korean Association of Orthodontists.The aim of this study is to compare the nutritional value of Alfalfa and accumulation of heavy metals in the farms near and far from the industrial regions. Three regions were considered located at 2, 32 and 65 km distances from an industrial region, and the nutrient content of the Alfalfa including crude protein, crude fiber, crude fat, nitrogen-free extract, and Ash as well as soil and plant heavy metals was determined. The results showed no significant difference in the value of nutrients in the three regions except nitrogen-free extract (mainly starch and sugars). A positive correlation was observed between nitrogen-free extract and lead, chromium, and arsenic (p ≤ 0.05). In addition, the highest accumulations of heavy metals such as arsenic, chromium, lead and cadmium were found in soil and Alfalfa produced at 2 km distance from the industrial area. The lead and cadmium concentrations were higher than the maximum allowable agricultural soil concentration in the areas near industrial region; the accumulation of these metals in the Alfalfa was however lower than the cattle and plant risk levels. The distribution of heavy metals in the Alfalfa cultivated in these three areas (zinc > copper > lead > chromium > arsenic > cadmium) did not coincide with the average of these metals in the soils (lead > zinc > chromium > copper > cadmium > arsenic). The positive correlation was also recorded between electrical conductivity of agricultural soils and copper, lead, chromium and arsenic content of Alfalfa. The highest translocation factors of arsenic, chromium and lead elements were detected in industrial areas. selleck For copper and zinc, the highest translocation factor was found in non- industrial areas. The results of this study can be applied as an important control program in different areas. © Korean Society of Toxicology 2019.There are only a few reports on the effects of mycotoxins on pheasant (Phasianus colchicus) and the susceptibility to deoxynivalenol of these birds have never been reported before. The present experiment focuses to investigate the effects of different dietary concentrations of deoxynivalenol on blood plasma protein content, some parameters of lipid peroxidation and glutathione redox system and on the performance of pheasant chicks. A total of 320 1-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with deoxynivalenol (control, 5.11 mg/kg, 11.68 mg/kg and 16.89 mg/kg). Birds were sacrificed at early (12, 24 and 72 h) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the oxidative stress-inducing effect of deoxynivalenol. Feed refusal was dose dependent, especially in the last third of the trial, but only minor body weight gain decrease was found. Lipid-peroxidation parameters did not show dose-dependent effect, except in blood plasma during the early stage of the trial. The glutathione redox system, reduced glutathione content and glutathione peroxidase activity, was activated in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Comparing our results with literature data, pheasants seem to have the same or higher tolerance to deoxynivalenol than other avian species, and glutathione redox system might contribute in some extent to this tolerance, as effective antioxidant defence against oxidative stress. © The Author(s) 2019.Arylquin 1, a small-molecule prostate-apoptosis-response-4 (Par-4) secretagogue, targets vimentin to induce Par-4 secretion. Secreted Par-4 binds to its receptor, 78-kDa glucose-regulated protein (GRP78), on the cancer cell surface and induces apoptosis. In the present study, we investigated the molecular mechanisms of arylquin 1 in cancer cell death. Arylquin 1 induces morphological changes (cell body shrinkage and cell detachment) and decreases cell viability in various cancer cells. Arylquin 1-induced cell death is not inhibited by apoptosis inhibitors (z-VAD-fmk, a pan-caspase inhibitor), necroptosis inhibitors (necrostatin-1), and paraptosis inhibitors. Furthermore, arylquin 1 significantly induces reactive oxygen species levels, but antioxidants [N-acetyl-l-cysteine and glutathione ethyl ester] do not inhibit arylquin 1-induced cell death. Furthermore, Par-4 knock-down by small interfering RNA confers no effect on cytotoxicity in arylquin 1-treated cells. Interestingly, arylquin 1 induces lysosomal membrane permeabilization (LMP), and cathepsin inhibitors and overexpression of 70-kDa heat shock protein (HSP70) markedly prevent arylquin 1-induced cell death. Therefore, our results suggest that arylquin 1 induces non-apoptotic cell death in cancer cells through the induction of LMP. © Korean Society of Toxicology 2019.Tartrazine (E102) is a synthetic food coloring, which belongs to the class of mono azo dyes and is known to cause numerous health problems. The current research aimed to evaluate the effect of this food dye on the enzymatic activity of amylase, lipase and proteases after a subchronic ingestion in Swiss mice. Additionally, an in vitro digestion model was used to highlight the relationship between the probable toxicity of tartrazine and the nature of the food ingested. The results show that there were no adverse effects of tartrazine on the body weight gain, and on amylase or lipase activities. However, in the high dose of tartrazine (0.05%) group, a significant decrease in trypsin and chymotrypsin enzymatic activities were observed. Regarding the in vitro digestion model, our findings show that there were no changes in the trypsin and chymotrypsin enzymatic activities either using 7.5 or 75 mg of tartrazine mixed with rice, butter or milk. We conclude that excessive consumption of tartrazine appears to alter the enzymatic activity of proteases in vivo which may have deleterious consequences on digestion.
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