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Outcomes of Hormone Contraceptive Use on Psychological Functions in Patients With Bulimia Therapy.
05). V.This work reports the synthesis of novel antibacterial magnetic-/pH-sensitive hydrogel beads based on ionotropic-gelation of alginate biopolymer. Using pomegranate peels extract, green-Ag nanoparticles were synthesized inside a mixture of alginate and Fe3O4, via in situ method. The alginate beads were investigated by VSM, TEM, XRD, and FE-SEM techniques. The introducing Ag and Fe3O4 nanoparticles in hydrogel beads caused a reduction in the swelling capacity of hydrogel beads. Besides, a pH-dependent swelling behavior was observed for hydrogel beads with a maximum swelling capacity at pH = 7.4. Diclofenac sodium (DS) as a model drug was loaded in hydrogel beads and its release showed a pH-dependent behavior. Drug release studies exhibited significant behaviors on the subject of physiological simulated pHs with a high release rate at pH = 7.4. The alginate beads have shown a prolonged and successive controlled drug release nearly 83% at pH = 7.4 and time 200 min. In addition to the pH, the release of DS from magnetic beads was affected by the external-magnetic-fields. Also, the Ag-incorporated alginate beads showed strong antibacterial activity against S. aureus and E. coli. These results indicated that the hydrogel beads have potentially applicable in drug delivery systems. V.Natural protein-based nanoparticles are promising nano-vehicles for the delivery of chemotherapeutic drugs. Caseinate nanoparticles loaded with doxorubicin (CasNPs-DOX) have been surface-modified with the natural polysaccharide alginate to generate the novel nanocarrier Alg-CasNPs-DOX. The fabricated nanoparticles have been characterised by transmission electron microscopy, Fourier-transform infrared spectroscopy, dynamic light scattering, fluorescence spectroscopy, and zeta potential measurement. Drug encapsulation and release profiles were also investigated. In vivo studies were conducted to evaluate the therapeutic efficacy of this novel drug delivery system in tumour-bearing mice. The biodistribution and toxicity of the nano-formulation were also assessed. The results showed that encapsulation of DOX in Alg-CasNPs-DOX not only led to controlled and sustained drug release but also significantly enhanced the effectiveness of DOX against Ehrlich carcinoma. Moreover, no significant changes were observed in liver and kidney enzymes, indicating the selective delivery of DOX to the tumour site, thus minimising DOX toxicity to certain vital organs. Accordingly, Alg-CasNPs-DOX was shown as a promising DOX nanocarrier for improving the therapeutic efficacy of DOX against cancer compared to that of free DOX. Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration. In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial. Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). The PPS/rGO composition of 90 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel. Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped. A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses. Overall, the result confirmed the appropriateness of PPS/rGO for tissue engineering uses. V.Berberine hydrochloride (BBH) has been used to treat diarrhea and other gastrointestinal diseases, however its therapeutic efficacy is compromised because of poor aqueous solubility and dissolution. In this work, BBH was solubilized with β-cyclodextrin (β-CD) in aqueous solution through formation of the BBH/β-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY. The aqueous solubility of BBH at 25 °C was increased by ca. 102% in the presence of 16 mM β-CD. BBH/β-CD IC-loaded bacterial cellulose (BC) hydrogels (denoted as BC/IC) were prepared by physical absorption method, resulting in higher drug loading capacity (DLC) than BC/BBH hydrogels. In vitro drug release showed that sustained drug release was achieved at different pH conditions simulating the gastrointestinal fluids by BC/IC hydrogels due to the hyperfine network of BC matrix. Furthermore, in vitro anti-bacterial test demonstrated the BC/IC hydrogels induced effective bacterial inhibition. Together with the good biocompatibility and edibility of the BC matrix, these BC/IC hydrogels appear to be promising candidates of oral administration medicine against gastrointestinal infections. V.BACKGROUND There are little data on the outcomes of primary total hip arthroplasties (THAs) in patients with a prior surgically treated hip or knee periprosthetic joint injection (PJI). The goal of this study was to compare the risk of infection in this population with matched controls. METHODS We retrospectively reviewed 48 patients whom underwent 50 primary THAs from 2000 to 2014 with a history of a PJI in a total knee arthroplasty or contralateral THA. Thirteen patients (27%) were on chronic antibiotic suppression at the time of primary THA. Mean age was 67 years, and mean body mass index was 35 kg/m2. Cucurbitacin I in vivo Mean follow-up was 6 years. We 13 matched (age, sex, body mass index, cemented vs cementless femoral fixation, and surgical year) these cases to 150 primary THAs. Competing risk analysis, with death as the competing risk, was performed. RESULTS The cumulative incidence of PJI with death as a competing risk was 1.5-fold higher in the study cohort (2.0%) compared with matched controls (1.4%) (hazards ratio, 1.
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