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Photoplethysmography can be used to estimate many physiological parameters based on features extracted from the measured waveform. Following the single parameter estimations that have been reviewed in part 1 of this paper, we here review methods where the waveform is used in conjunction with other measured physiological signals. Being a low-cost, non-invasive, and user friendly technique, many PPG-based physiological data extraction methods are being researched. The parameters reviewed that can be estimated using the PPG waveform plus additional inputs include cardiac output, blood pressure, venous function assessment, blood oxygen saturation, and fetal heart rate and fetal oxygen saturation. selleckchem The different processing techniques, algorithms and methods are reviewed in addition to providing a comparison of results with the reference standards to validate the different methods. Future research considerations for each parameter estimation are also discussed. This paper could be helpful for future research on PPG based wearable devices for physiological multi-parameter estimations.Cerebellar ataxia (CA) results from injury to or disease of the cerebellum. It describes the resulting motor dysfunction, characterised by inaccuracy, incoordination and delay in initiation of movement, tremor, and imbalance. Assessment of ataxia to diagnose and monitor progress is by clinical observance of the performance of standard motor tasks. An accurate instrumented measurement of CA would therefore be of great interest. This study was aimed at assessing upper-limb ataxia during ballistic tracking of a computer-generated target in individuals with CA and controls using motion measures obtained from a Kinect camera and a wearable motioncaptured device. A set of features derived from these motion measurements were used to develop a method for objective quantification of CA. Difference between ataxic and non-ataxic movements can be readily be observed in features from both devices (p= 0.008) and their values associated with a standard clinical scale (rho = 0.80, p less then 0.001). The combination of multimodal features improved the ability to distinguish between CA subjects and controls and to measure the severity of upper limb ataxia.Pre-detection of hypertension mostly considers the measurement of Brachial Artery Blood Pressure (BABP). Although being a standard vital, it is still considered a poor alternative for Central Blood Pressure (CBP). However, CBP is measured invasively during the process of cardiac catheterization (Cath). Though cuff-less techniques to estimate BABP are widely employed, CBP estimation has not been explored yet. Moreover, to best of our knowledge intermittent CBP estimation has not been proposed earlier. Therefore, we present a cuff-less and beat-by-beat CBP estimation technique using linear regression analysis on features extracted from continuous Electrocardiogram (ECG) and Photoplethysmograph (PPG) signals. Unlike for BABP estimation, 30 supplementary features to conventional pulse transit time such as ST-interval, Psystolic peak interval, etc., were extracted to enhance CBP accuracy. This extraction was done using Haar wavelet along with modulus maxima. Feature selection has been done using the wrapper technique and reduced using principal component analysis. Segregation of each beat was achieved with the help of constraints developed based on iteration and backtracing. This model estimates Systolic CBP with a validation error of 0.109±2.37 mmHg and Diastolic CBP with an error of 0.031±2.102 mmHg for 33 Cath lab patients.Air Traffic Control (ATC) has been classified as the fourth most stressful job. In this regard, sixteen controllers were asked to perform ecological ATC simulation during which behavioral (Radio Communications with pilots - RCs), subjective (stress perception) and neurophysiological signals (brain activity and skin conductance - SC) were collected. All the considered parameters reported significant changes under high stress conditions. In particular, the theta, alpha, and beta brain rhythms increased significantly (all p less then 0.05) all over the brain areas, and both the SC components exhibited higher values (p less then 0.01). Additionally, the number of speech under high stress decreased significantly (p less then 10-4) while both the mean and median value of the F0 component of the RC increased (p less then 0.01). The results can be employed to objectively measure and track the controller's stress level while dealing with ATC activities to better tailoring the workshift and maintaining high safety levels.Parkinson's disease (PD) patients with freezing of gait (FOG) can suddenly lose their forward moving ability leading to unexpected falls. To overcome FOG and avoid the falls, a real-time accurate FOG detection or prediction system is desirable to trigger on-demand cues. In this study, we designed and implemented an in-place movement experiment for PD patients to provoke FOG and meanwhile acquired multimodal physiological signals, such as electroencephalography (EEG) and accelerometer signals. A multimodal model using brain activity from EEG and motion data from accelerometers was developed to improve FOG detection performance. In the detection of over 700 FOG episodes observed in the experiments, the multimodal model achieved 0.211 measured by Matthews Correlation Coefficient (MCC) compared with the single-modal models (0.127 or 0.139).Clinical Relevance- This is the first study to use multimodal EEG and accelerometer signal analysis in FOG detection, and an improvement was achieved.Investigating the electroencephalography (EEG) correlates of human emotional experiences has attracted increasing interest in the field of affective computing. Substantial progress has been made during the past decades, mainly by using EEG features extracted from localized brain activities. The present study explored a brain network-based feature defined by EEG microstates for a possible representation of emotional experiences. A publicly available and widely used benchmarking EEG dataset called DEAP was used, in which 32 participants watched 40 one-minute music videos with their 32channel EEG recorded. Four quasi-stable prototypical microstates were obtained, and their temporal parameters were extracted as features. In random forest regression, the microstate features showed better performances for decoding valence (model fitting mean squared error (MSE) = 3.85±0.28 and 4.07 ± 0.30, respectively, p = 0.022) and comparable performances for decoding arousal (MSE = 3.30±0.30 and 3.41 ±0.31, respectively, p = 0.
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