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NMR Rest Rates of Quadrupolar Aqueous Ions via Time-honored Molecular Dynamics Utilizing Force-Field Specific Sternheimer Components.
The present study aimed to investigate whether there are basic numerical processing deficits in high math anxiety (HMA) individuals and examine the effects of cognitive inhibition on the performance of high and low math anxiety (LMA) individuals. 35 undergraduate students were recruited to perform a numerical comparison task, a numerical Stroop task, a dot comparison task, and a dot Stroop task. Results showed the following (1) Compared with LMA group, HMA group reacted more slowly and exhibited more fixation counts in non-symbolic representation task. (2) Inhibition condition significantly increased HMA individuals' fixation durations, whereas the fixation durations of LMA individuals were similar between inhibition and non-inhibition condition. The results demonstrated that MA might temporarily occupy individuals' working memory resources. (3) In non-symbolic representation task, the effect of numerical ratio on fixation counts was larger for HMA group than that for LMA group under inhibition condition, indicating MA might arise from a basic level deficit in numerosity processing.Purpose To report a case of melanoma-associated retinopathy (MAR) with autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1) with asymmetric severe vision loss. Methods We evaluated a patient with heel skin melanoma showing progressive vision loss in both eyes confirmed with a baseline ophthalmic examination, fluorescein angiography, spectral domain optical coherence tomography (OCT), visual field test, and full-field electroretinogram (ERG). Immunofluorescence assays and western blot analysis revealed autoantibodies in the patient's serum. Results The patient's best-corrected visual acuities were 20/50 in the right eye and hand motion in the left eye. Visual field test showed severely depressed visual fields especially in the left eye. Fluorescein angiography and OCT revealed extrafoveal choroidal neovascularization in the left eye. The patient had an electronegative ERG, suggesting MAR, and autoantibodies against TRPM1 and aldolase C were detected in the patient's blood sample. Conclusions The clinical features of MAR patients with positive anti-TRPM1 autoantibodies can be manifested as severe vision loss, and the identification of autoantibodies can be helpful for confirming the diagnosis.Body Dysmorphic Disorder (BDD) is a psychiatric diagnosis of an impairing condition in which the patient is preoccupied with a slight or perceived defect in their appearance. BDD patients have a higher rate of psychiatric comorbidities than the background population which include obsessive-compulsive disorder (OCD), depression, anxiety and suicide. It causes distress and affects the patient's quality of life. It is previously found that the prevalence of patients that suffers from BDD is higher among dermatology patients than in the background population. To create an overview of the original literature that exist on topic BDD in dermatology. A systematic review was conducted by two reviewers. PubMed was searched using a predefined search string created in collaboration between the authors and a bibliographic fellow on 18th of August 2018 and again in January 2020. 45 articles were obtained and after exclusion 5 relevant articles remained. Dermatology patients have a higher incidence of BDD than the background population. BDD patients are significantly younger and it has been suggested that BDD develops during adolescence but is diagnosed with a delay of several years because patients seek out health care professionals among non-mental health specialists. BDD does not appear associated with the setting, i.e. cosmetic vs general dermatology, but BDD patients have a lower quality of life and are more commonly unemployed or on sick leave. It is often difficult to treat, and a combination of the dermatologic treatment and the psychiatric treatment may be necessary in the context of visible skin pathology.Purpose Computed tomography pulmonary angiography (CT-PA) is the diagnostic modality used for pulmonary embolism (PE). This study aimed to estimate the positive CT-PA rate and identify the predictors of positive CT-PA results. Methods A retrospective observational study was conducted by examining the CT-PA data for ruling out PE in all adult patients who visited the King Fahd Hospital of Imam Abdulrahman Bin Faisal University. The data regarding background demographic information, clinical information, and CT-PA findings were collected from electronic health records. Data were analyzed descriptively using the chi-squared test. Multivariate regression analysis was used to identify the predictors of positive CT-PA results. Results In total, 548 patients (209 male, 339 female) who underwent CT-PA scans were included. The positive CT-PA rate was 18.8%. The Charlson Comorbidity Index was not significantly associated with positive CT-PA results (p = 0.456). Multivariate logistic regression analysis revealed that smoking (odds ratio [OR] 4.96; 95% confidence interval [95% CI] 2.05-12.02) was an independent factor associated with positive CT-PA results. The CT-PA scans performed in winter and spring were 43% (OR 0.43; 95% CI 0.22-0.84) and 52% (OR 0.52; 95% CI 0.28-0.97) less likely to show positive results compared with those performed in autumn, respectively. Conclusion The positive CT-PA rate varied significantly between seasons. Smoking was a predictor of positive CT-PA results. These findings may assist in developing interventions for improving the utilization of CT-PA scans to avoid unnecessary exposure of patients to radiation. AL3818 mw Clinical trial registration N/A.Background Static [18F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence/progression as well as assess further relationships with patient outcome. Methods Fifty-one consecutive patients who underwent an [18F]-F-DOPA PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters, including mean and maximum tumor-to-normal-brain (TBR) ratios, tumor-to-striatum (TSR) ratios, and metabolic tumor volume (MTV), as well as dynamic parameters with time-to-peak (TTP) values and curve slope, were tested for predicting the following (1) glioma recurrence/progression at 6 months after the PET exam and (2) survival on longer follow-up. Results All static parameters were significant predictors of glioma recurrence/progression (accuracy ≥ 94%) with all parameters also associated with mean progression-free survival (PFS) in the overall population (all p less then 0.
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