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"We have been warned"-preparing now to avoid the up coming pandemic.
Localrecurrence rates (LRRs) after Mohs micrographic surgery (MMS) for male genital cancers have been reported in only a few small case series, and patient-reported outcomes (PROs) have not been studied.

To determine the LRR and PROs after MMS for male genital skin cancers.

Retrospective review of all male genital skin cancers removed with MMS between 2008 and 2019 at an academic center. LRR was determined by chart review and phone calls. PROs were assessed by survey.

A total of 119 skin cancers in 108 patients were removed with MMS. Tumors were located on the penis (90/119) and scrotum (29/119). Diagnoses included squamous cell carcinoma in situ (n= 71), invasive squamous cell carcinoma (n=32), extramammary Paget disease (n=13), melanoma (n=2), and basal cell carcinoma (n=1). The LRR was 0.84% (1/119), with a mean follow-up time of 3.25years (median, 2.36years). The majority of survey respondents reported no changes in urinary (66%) or sexual functioning (57.5%) after surgery.

Retrospective single-center experience; short follow-up time; low survey response rate; no baseline functional data.

MMS for male genital skin cancer has a low LRR and high patient-reported satisfaction with urinary and sexual function.
MMS for male genital skin cancer has a low LRR and high patient-reported satisfaction with urinary and sexual function.Human's uncertain decision-making involves choices of risk (with known probabilities) and ambiguity (with unknown probabilities). For risky and ambiguous decision-making processes, neural differences are rarely exhibited. To clarify the causal role of the right dorsolateral prefrontal cortex (DLPFC) in uncertain situations, we used transcranial direct current stimulation (tDCS) to demonstrate the involvement of the right DLPFC in decisions involving risk and ambiguity. Participants received either anodal or cathodal tDCS at 1.5 mA or sham stimulation over the right DLPFC and subsequently undertook tasks of risk and ambiguity. The results revealed that a preference for ambiguity could be measurably increased in individuals through anodal stimulation, but no significant differences were observed in the preferences for risky choices among groups. These findings suggest that different neural mechanisms underlie risky and ambiguous decisions because the right DLPFC primarily affects ambiguous behavior.The grey mouse lemur (Microcebus murinus) is a promising nonhuman primate model for brain ageing and neurodegenerative diseases. see more Age-related cognitive decline in this model is well described, however, data on possible relations between attention and age, as they are known from humans, are missing. We tested 10 mouse lemurs in a touchscreen-based version of the 5-choice-serial-reaction-time-task (5CSRTT) on visuo-spatial attention subjects had to interact with a briefly presented stimulus occurring unpredictably in one out of five locations on the touchscreen. Animals were trained to an 80 % performance at a four seconds stimulus presentation duration (SPD) and subsequently challenged by a SPD of two seconds. Additionally, ventricular expansion was assessed using structural magnetic resonance imaging. Trials to the 80 % criterion at four seconds SPD correlated significantly with age and with ventricular expansion, especially around the occipital lobe. Once criterion performance was reached, two seconds challenge performance was independent of age. In four subjects that were additionally challenged with 1.5, 1.0, 0.8, or 0.6 s SPDs or variable delays preceding stimulus presentation, performance linearly declined with decreasing SPD, i.e. increasing attentional demand. In conclusion, this is the first report of 5CSRTT data in mouse lemurs and demonstrates the general applicability of this task of visuo-spatial attention to this nonhuman primate model. Results further demonstrate age-related deficits in learning during acquisition of the 5CSRTT and suggest that both may be linked through age-related atrophy of occipital structures and a resulting deficit in central visual processes.Cognitive reappraisal is an important emotion regulation skill for psychological health and well-being, however, some people cannot use this strategy effectively. We investigated EEG alpha asymmetry by calculating lateral index (LI) when twenty-six healthy participants were instructed to complete the emotion cognitive reappraisal task of viewing neutral pictures, watching negative pictures and reappraising negative pictures. According to self-reported valence and arousal, the participants were divided into effective and ineffective groups. Habitual use of rumination was also assessed using the Cognitive Emotion Regulation Questionnaire (CERQ). EEG alpha asymmetry results demonstrated that, ineffective group showed greater relative right temporal activity than effective group in the early stage of reappraisal, indicating higher subjective arousal. Both groups showed greater relative left frontal alpha activity in the late stages of reappraisal compared with watching negative images, indicating the recruitment of corresponding functions in prefrontal regulatory circuitry during the effort of reappraisal. CERQ analysis results showed that, ineffective group got significantly higher score than effective group in habitual use of rumination. Partial correlation revealed that, in male participants, temporal LI change (negative-reappraisal minus negative-watch) was negatively correlated with self-reported arousal and habitual use of rumination. In addition, by using K-means cluster analysis, temporal LI combined with CERQ-rumination score achieved a classification accuracy of 84.6 %. These findings suggested that, EEG alpha asymmetry as well as the habitual use of rumination accounted for the reappraisal effectiveness.Heterologous sensitization of adenylyl cyclase (AC) is defined by an enhanced cAMP response following persistent activation of Gαi/o-coupled receptors. This phenomenon was first observed in cellular models, and later reported in animal models of inflammatory pain or following chronic exposure to drugs of abuse including opioids and cocaine. Recently, we used genome-wide siRNA screening to identify Cullin3 signaling as a mediator of AC sensitization in cellular models. We also showed that pharmacological inhibition of Cullin3 with the neddylation inhibitor, MLN4924, abolished heterologous sensitization of several AC isoforms, including AC1, AC2, AC5, and AC6. Because ACs, especially AC1, have been implicated in alcohol-induced locomotor sensitization and inflammatory pain, we assessed the potential activity of MLN4924 in both murine models. We found that MLN4924 (30 mg/kg, i.p.) accumulated in the brain and reduced both locomotor sensitization induced by repeated alcohol administration and allodynia in an inflammatory pain model.
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