Notes

The HER2 Tri-Specific NK Mobile Engager Mediates Effective Targeting involving Man Ovarian Cancer.
The most common presenting symptom was generalized weakness. The most common morphological type was normocytic normochromic anemia, and chronic diseases were the commonest etiological factors.

In spite of modern diagnostic advances, geriatric anemias still remain under-reported and inadequately investigated, necessitating evaluation of even mild anemias. Prompt diagnosis and definite categorization helps in appropriate management of anemias.
In spite of modern diagnostic advances, geriatric anemias still remain under-reported and inadequately investigated, necessitating evaluation of even mild anemias. Prompt diagnosis and definite categorization helps in appropriate management of anemias.
Malnutrition is an under recognized, but common issue in elderly patients. This study aimed to investigate the prevalence of poor nutritional status and identify comprehensive geriatric assessment-based clinical factors associated with increased malnutrition risk to assessing malnutrition risk in hospitalized elderly patients in China.

A total of 365 elderly hospitalized patients (178 women, 76.37±7.74years) undertook a comprehensive geriatric assessment (CGA), and have their nutritional status assessed using the short-form mini-nutritional assessment.

Among 365 patients, 32 (8.77%) were malnourished and 112 (30.68%) were at risk of malnutrition. A logistic regression analysis showed that age (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.13-2.23), alcohol consumption (OR, 2.04; 95% CI, 1.19-3.48), presence or history of cancer or heart failure (OR, 3.48 and 2.86; 95% CI, 1.49-8.13 and 1.12-7.27), depression (OR, 2.86; 95% CI, 1.97-4.17), body mass index (OR, 5.62; 95% CI, 3.62-8.71), being depex, function status, recent fall(s), cognitive impairment, insomnia, and low hemoglobin and albumin levels were independently associated with malnutrition in these patients. Comprehensive geriatric assessment can provide detailed information of older patients and can be a useful tool for assessing malnutrition risk-associated factors.
Delirium incidences during hospitalization are an important problem in elderly patients. The problem of delirium episodes in patients with obstructive disease during hospitalization was investigated.

From a total of 37,156 subjects, the following were randomly selected 32,261 patients with asthma, 4896 with chronic obstructive pulmonary disease (COPD), and 5455 without obstructive disease. Their ages ranged from 65-95 years, and they were hospitalized between 2006 and 2015. Delirium incidences were monitored based on the International Classification of Disease (ICD)-10 codes and medical documentation.

The delirium episodes during all hospitalizations were independently associated with asthma (odds ratio [OR]=2.91, confidence interval [CI]=1.62-5.84), with severe type of asthma (OR=4.24, CI=1.94-8.93), partim controlled asthma (OR = 3.1, CI=1.29-8.46), and uncontrolled asthma (OR = 4.88, CI=2.12-9.42). It was comparable with COPD as follows all incidences of delirium during hospitalization (OR=3.17, CI=1.42-7.23) or severe COPD (III degree OR = 5.15, CI=2.01-13.69). Elderly patients with asthma with uncontrolled or partially controlled asthma with a coincidence of advanced age, dementia, or smoking had a greater predisposition to delirium episodes, particularly after surgery. Additionally, delirium incidence caused death more frequently in patients with asthma than in those with COPD.

Elderly patients with asthma have a higher risk of delirium episodes during any hospitalization, and, frequently, it ends in death.
Elderly patients with asthma have a higher risk of delirium episodes during any hospitalization, and, frequently, it ends in death.
The aim of this study was to analyze the sensitivity and specificity of a shortened Hasegawa Dementia Scale Revised (shortened HDS-R) questionnaire and explore its utility for the rapid screening and diagnosis of Alzheimer's disease (AD).

We included 113 patients over the age of 60years who visited our hospital from June 2018 to January 2021 including 70 subjects with AD and 43 healthy subjects. AD was diagnosed in accordance with the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the standard HDS-R questionnaire was used as a neuropsychological examination. The shortened HDS-R questionnaire was composed of the first seven subdomains (1 to 7) of the HDS-R questionnaire and excluded subdomains 8 and 9. Magnetic resonance imaging (MRI) was performed to calculate the degree of atrophy of the whole brain, hippocampus, and parahippocampal gyrus.

The cumulative contribution ratio of subdomains 1 to 7 of the HDS-R questionnaire was as high as 94%, indicating he specificity was 88.4%. The diagnostic ability of the shortened HDS-R was 91.2%, which indicates that it is similar to the full HDS-R questionnaire as an AD screening tool.

As a neuropsychological examination questionnaire for the screening and diagnosis of AD, the shortened HDS-R had very high validity and reliability. Its sensitivity, specificity, and diagnostic ability were similar to those of the gold standard HDS-R; therefore, it can be considered a concise and useful questionnaire for AD screening and diagnosis in the older population.
As a neuropsychological examination questionnaire for the screening and diagnosis of AD, the shortened HDS-R had very high validity and reliability. Its sensitivity, specificity, and diagnostic ability were similar to those of the gold standard HDS-R; therefore, it can be considered a concise and useful questionnaire for AD screening and diagnosis in the older population.With the demographic changes, more and more elderly people have chosen to spend their retirement life in a senior care facility. The elderly people in senior care facility are commonly suffering from various geriatric syndromes, including declined daily living activities, cognitive dysfunction, frailty, comorbidities, and polypharmacy, which make them vulnerable to adverse effects, like hypoglycemia and fall. selleck Therefore, layered management is necessary for this population with group disparities. However, the staff in senior care facility vary greatly in concepts and skills on management of senile diabetic population, which needs urgently to be standardized and improved. For this purpose, based on literature review and panel discussion, 28 recommendations are proposed in respect of the standardized management of blood glucose, covering the comprehensive assessment, layered management and grouping, exercise, nutrition, glucose monitoring, identification and treatment of severe hyperglycemia, identification of macrovascular and microvascular complications, management of hypoglycemic drugs, falls and choking and other common problems, blood glucose screening, hypoglycemia prevention, and blood glucose management in major public health events or serious natural disasters.
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