Notes

[Research advancement about primary orbital melanoma].
considered in pediatric FTCs, especially in cases less then 10 years of age. In all DICER1 variant-positive FTCs and FAs, recurrent hotspot variants were found at metal binding sites within the RNase IIIb domain, suggesting they impact tumorigenesis.Introduction The awareness of radiation doses and risks, also during interventional cardiology procedures, is essential today in order to apply the risk-benefit assessment and to reinforce the principles of justification and optimisation in clinical practice.Methods A voluntary survey with 10 questions and multiple-choice answers was run on a popular cardiology website (www.cardiolink.it) independently by a scientific publisher, in order to evaluate the contemporary level of radiation awareness in a multi-speciality sample of physicians in Italy.Results One thousand eight hundred and sixty-one physicians completed the test. The survey showed good results since both prescribers and practitioners (mostly cardiologists) working in Italy are largely aware of the cancer and non-cancer risks of medical radiation use, regardless of their subspecialty background.Conclusion Physicians are largely aware of the cancer and non-cancer risks of medical radiation use, regardless of their subspecialty background. However, there is still broad space for improvement; in the future, the awareness of radiation risk is a prerequisite to create a culture of respect for radiation hazard and a commitment to minimise exposure and maximise protection.Myeloid cell leukemia-1 (Mcl-1) protein is a family of Bcl-2 (B cell lymphoma 2) rich proteases of the most common increase threshold for genetic aberrations observed in human cancer, including lung, breast, pancreatic, cervical, and ovarian cancers as well as leukemia and lymphoma. Ceralasertib datasheet Mcl-1 is recognized as an attractive drug target in number of diseases, including cancer. In the present study we surveyed and collected queries compounds from PDB database of Mcl-1 protein and generated pharmacophore-based models adapted to screen the drug-like compounds from FDA approved database. The 206 best lead molecules from pharmacophore-screening were further evaluated by molecular docking, molecular dynamics simulation, MM-GBSA calculation, as well as experimental validation. Two hits, ZINC00601272 and ZINC00002166, showed the best docking scores, which showed a tendency to inhibit cell viability of HL60 and K562 leukemia cells with Mcl-1 expressions. Conclusively, the present study provides structural information of Mcl-1 inhibitors for next generations of cancer therapeutics through computational and experimental validation approach.Communicated by Ramaswamy H. Sarma.This study conducted scientific evidence linking neighbourhood built environment to adults' leisure-time physical activity (LTPA) among adults in China. Data were obtained from a questionnaire survey conducted from April to July 2017 among 1002 adults aged 18-69 years old in Pingshan District, Shenzhen, China. Chinese Walkable Environment Scale for urban community residents and International Physical Activity Questionnaire were used to measure participants' neighbourhood built environment and leisure-time physical activity, which was categorised into leisure-time walking (LTW) and leisure-time moderate-to-vigorous physical activity (LTMVPA). A total of 986 participants (mean age = 40.7 years, 53.3% females) were included in this research. Descriptive statistics were used to describe the socio-demographic variables, LTW and LTMVPA by sex. Multivariable logistic regression models were used to examine the association between neighbourhood environment characteristics and the likelihood of engaging in active LTW and LTMVPA. Only 20.7% of participants engaged in active LTW and 17.8% active LTMVPA. Better road condition was associated with higher likelihood of active (at least 150 min/week) LTW and LTMVPA. High perceived esthetic was positively associated with LTW and LTMVPA. Active LTW was related to better perception of traffic condition as well. The improvement of the neighbourhood environment characteristics can promote active LTPA among adults living in Shenzhen, China. Our findings support the importance of considering population health effects in urban planning and development.Objective The primary purpose of this study was to examine the longitudinal effects of sports-related concussion (SRC) on a multi-faceted assessment battery which included neuropsychological testing, symptom reporting, and enhanced brain function index (eBFI) among athletes with and without SRC. A secondary purpose was to explore longitudinal sex differences among these measures in athletes with and without SRC.Methods A case-control, repeated-measures design was used for this study. A total of 186 athletes (concussed groupn = 87 controlsn = 99) participated in the study. A repeated-measures design was used in which each athlete was tested at four time points following an SRC within 72 h of injury (Day 0; 2.0 ± 0.9 days following injury), 5 days following injury (Day 5; 5.0 ± 0.0), at return to play (RTP; 18.3 ± 13.8 days following injury), and within 45 days following RTP (RTP45; 66.2 ± 19.0 days following injury). All analyses were conducted separately using a 2 (Group concussed, control) × 2 (Sex male, feme points during recovery.This study validated sedentary behaviour (SB), moderate-to-vigorous physical activity (MVPA) and vigorous physical activity (VPA) accelerometer cut-points in 5-7-year-old children. Participants (n = 49, 55% girls) wore an ActiGraph GT9X accelerometer, recording data at 100 Hz downloaded in 1 s epochs, on both wrists and the right hip during a standardised protocol and recess. Cut-points were generated using ROC analysis with direct observation as a criterion. Subsequently, cut-points were optimised using Confidence intervals equivalency analysis and then cross-validated in a cross-validation group. SB cut-points were 36 mg (Sensitivity (Sn) = 79.8%, Specificity (Sp) = 56.8%) for non-dominant wrist, 39 mg (Sn = 75.4%, Sp = 70.2%) for dominant wrist and 20 mg (Sn = 78%, Sp = 50.1%) for hip. MVPA cut-points were 189 mg (Sn = 82.6%, Sp = 78%) for non-dominant wrist, 181 mg (Sn = 79.1%, Sp = 76%) for dominant wrist and 95 mg (Sn = 79.3%, Sp = 75.6%) for hip. VPA cut-points were 536 mg (Sn = 75.1%, Sp = 68.7%) for non-dominant wrist, 534 mg (Sn = 67.
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