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oubtedly representative, as patients from different regions of Kazakhstan were treated in two clinics of republican significance. In the future, it is necessary to conduct prospective studies with subsequent follow-up of patients after treatment and in identifying the causes of recurrent coronary events, as was done in the MESA study.The aim of the study was to optimize the methods of selecting patients for inclusion in the «WAITING LIST» for heart transplantation on the basis of available international data and the introduction of selection criteria. The results of the study are based on survey data and dynamic monitoring of 49 patients (median age 38 (16; 65) years, men 44 patients, women 5 patients) who were treated from 2008-2018 in the centers Republican Scientific and Practical Center «Cardiology», Minsk, Republic of Belarus; in the Center of cardiac surgery on the basis of KL «Feofania» DUS, Kyiv, Ukraine. Patients were examined during the initial examination, after 3 months, 6 months and after 1 year. The first group consisted of 24 patients with CHF who were on the waiting list for orthotopic heart transplantation, for circulatory support, median age 40.95 (18.0; 65.0) years, men - 23, women - 1; the second group consisted of 25 patients with CHF who were on the waiting list for orthotopic heart transplantation without circulatory support, median age 38.56 (17.0; 64.0) years, men -21, women-4; Scientific novelty of the obtained results. Scientific novelty of the obtained results. For the first time in Ukraine, a road map has been developed and implemented and the dynamics of the movement of recipients who are in the "waiting list" for heart transplantation has been analyzed. Identified risk factors that affect the long-term outcomes and quality of life of patients with heart failure III-IV functional class according to the NYHA classification. Criteria for selection of patients for primary heart transplantation have been developed and implemented. For the first time in Ukraine, a "Waiting List" for a heart transplant has been formed.The goal is to study the method of photodynamic therapy, which has become widespread in recent decades. This method of treatment has gained popularity in the treatment of both oncological and non-oncological inflammatory diseases in dentistry and other medical fields. We can conclude that the complex action of Rada Dent and Tskaltubo water (inhalation of Tskaltubo water and its use as rinses) leads to a gradual reduction and eventual eradication of the inflammatory process in the case of periodontitis. This can be explained by the unique properties that are characteristic of "Rada Dent" and Tskaltubo water. As we have seen, the above biochemical indicators are the determinants of periodontitis in patients with periodontitis, they are markers of the degree of periodontitis and we have clearly seen the complex action. High efficiency of "Rada Dent" and radon in the water of Tskaltubo - normalization of the action of oral enzymes, slowing down the inflammatory processes in the oral cavity and finally eradication. It is these unique properties that have become triggering the treatment and inhibit the initial stage of periodontitis.Aim of the study -to determine the indices of local immunity in patients who had combined dental pathology (caries) and gastroesophageal reflux disease. In total were exanimated 33 patients with dental caries in age from 18 to 25 years, including 21 men and 12 women. The main group consisted of 17 patients who had a combined dental pathology (caries) and gastroesophageal reflux disease. The comparison group consisted of 16 people who had dental caries without other systemic diseases. All patients, who were included in the study was carried out the following researches a study of the dental status, an immunological study for all patients with the determination of a quantitative assessment of the main populations and subpopulations of lymphocytes, determination of their functional activity, determination of level of serum immunoglobulins, determination of the concentration of circulating immune complexes of various molecular sizes, phagocytic activity of neutrophils and cytokine status in serum and oral fluid, stimulation, and also a significantly lower concentration of secretory IgA. It has been established that in patients with gastroesophageal reflux disease combined with dental caries observing changes in the immune system, which bear the features of subclinical immune inflammation. The study revealed a higher intensity of the carious process in patients with gastroesophageal reflux disease, which is associated with permanent acid damage of the oral mucosa. Furthermore, it was found violation in terms of concentration with increasing local immunity oral liquid proinflammatory factors and a reduced concentration of secretory IgA namely with concomitant pathologies of the gastroesophageal reflux disease.Aim of the study was to assess electrophysiologic characteristics of masticatory muscles, right and left temporalis and right and left masseter, in nasal and oronasal breathing modes. The study was conducted on the group of 30 female volunteers who were referred to the clinic for orthodontic problems. Conflict of interests was ruled out. The research was carried out within a frame of population-based study. In subjects with nasal breathing electromyographic indicators fall within standardized range. In the group of subjects with oronasal breathing electrical activity of masseter and temporalis muscles is asymmetrical. selleck kinase inhibitor Asymmetry between sides and unevenness between muscle pairs during normalized muscle activity may result from functionally unstable occlusion. When teeth clench on a cotton roll, dentoalveolar proprioceptive signal is too weak to affect electromyographic indicators offering possibility to obtain data solely on muscle activity during maximal voluntary contraction. Indicators of the degree of mean muscle contractility recorded as a result of standardized maximal voluntary contraction show that, in nasal breathing, muscle activity is homogenous and symmetric in the right and left masseter and temporalis muscles, while, in oronasal breathing, it becomes more dissociated with electrical activity - more pronounced in temporalis muscles. Electrophysiologic activity and, consequently, contractility of both temporalis and masseter muscles are reduced compared to subjects with nasal breathing which must be caused by recruitment of less excitable motor units. Results yielded by the study suggest the significance of the state of neuromuscular balance of the masticatory apparatus in the assessment of orthodontic status and possibility of applying electromyographic indicators to estimate the degree of orthodontic dysfunction and develop individualized treatment plans. Study continues in this respect.
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