Notes

A longitudinal approach regarding lockdown results upon standard of living as well as the appearance involving anxiety-depressive disorders as outlined by nerve organs processing level of responsiveness.
The patient underwent surgical aortic repair using the David technique. At present, the patient continues a close follow-up with advanced cardiac imaging (including cardiac magnetic resonance) for BAV surveillance and accurate detection of all aortic measures.
So far, the only available data for edoxaban periprocedural management come from the ENGAGE AF-TIMI 48 trial. The recently published EMIT-AF/VTE study showed low periprocedural bleeding and thromboembolic risks of edoxaban in a real-world setting in patients undergoing any diagnostic or therapeutic procedures. The aim of this study was to compare descriptively Italian and European data with regard to patient characteristics and outcomes in the EMIT-AF/VTE study.

A total of 1155 patients treated with edoxaban for stroke prevention in non-valvular atrial fibrillation and with venous thromboembolism, and undergoing a wide range of diagnostic and therapeutic procedures were enrolled in 326 centers across Europe. Of these patients, 246 were from 43 Italian centers. The periprocedural interruption of edoxaban was at the physician's discretion. All the procedures were classified into minor, low, and high bleeding procedural risk according to the European Heart Rhythm Association (EHRA) definition. The primary ourest of Europe. The safety and efficacy of edoxaban was confirmed in Italy even if patients were older, presented more frequently with cancer, and there was a higher rate of high bleeding risk procedures by EHRA definition.
In the EMIT-AF/VTE study, the number of bleeding and thromboembolic events in patients treated with edoxaban undergoing elective or unplanned procedures was low either in Italy or in the rest of Europe. The safety and efficacy of edoxaban was confirmed in Italy even if patients were older, presented more frequently with cancer, and there was a higher rate of high bleeding risk procedures by EHRA definition.
In patients with an indication for oral anticoagulation (OAC) with warfarin, the management of OAC peri-procedure of percutaneous coronary intervention (PCI) is still not fully defined. To investigate clinical practice and outcomes associated with continuation vs interruption of OAC, with or without bridging with low-molecular-weight heparin (LMWH), we examined the database of the observational, prospective, multicenter Italian WAR-STENT registry.

The WAR-STENT registry was conducted in 2008-2010 in 37 Italian centers and included 411 consecutive patients in 157 of whom the peri-procedural international normalized ratio (INR) value was available. In relation to the continuation vs interruption of OAC, patients were divided into group 1 (n = 106) and group 2 (n = 51) respectively, and compared.

The basal characteristics of the two groups were similar. The most frequent indication for OAC was atrial fibrillation and for PCI acute coronary syndromes, respectively. The pre-procedural mean value of INR was sH bridging) strategies appears similar in terms of efficacy and safety. read more In consideration of the superior convenience, peri-procedural continuation of OAC should therefore generally be preferred, with the possible exception of patients in whom the femoral approach is required for the procedure.
In unselected patients with an indication for OAC with warfarin and undergoing PCI, the continuation vs interruption of OAC (essentially without LMWH bridging) strategies appears similar in terms of efficacy and safety. In consideration of the superior convenience, peri-procedural continuation of OAC should therefore generally be preferred, with the possible exception of patients in whom the femoral approach is required for the procedure.Coronary artery disease (CAD) and severe aortic stenosis (AS) often coexist. When significant coronary lesions were found in patients undergoing surgical aortic valve replacement, combined coronary artery bypass grafting was the gold standard of treatment. Differently, the management of concomitant CAD in patients who are candidates for transcatheter aortic valve implantation (TAVI) is a matter of debate. In this review, we discuss the evidence and present the current viewpoints regarding the definition and prognostic implications of CAD in patients undergoing TAVI and the potential role and limitations of invasive functional coronary stenosis assessment in severe AS. We present the challenges of percutaneous coronary intervention (PCI) in this setting, including timing of intervention, completeness of revascularization in the context of the complexity of the disease and the risk associated with the PCI procedure itself. Finally, we mention ongoing trials that should provide some long-awaited answers in this field.Orthostatic hypotension is a medical condition potentially debilitating and associated with a negative prognosis. It is paramount for cardiologists to recognize it, mostly for the following reasons it is a predictive factor for cardiovascular events, it may cause syncope, and it is frequently associated with supine hypertension. Orthostatic hypotension may be secondary to neurogenic etiology (baroreflex dysfunction) or non-neurogenic etiology (dehydration or medication-related). Although laboratory tests exploring the autonomic nervous system are required for a detailed etiologic diagnosis, medical history and a sphygmomanometer can be sufficient for diagnosis. Therapeutic management of orthostatic hypotension is challenging, mostly because of the association in half of the cases with supine hypertension. Treatment should be a compromise between anti-hypotensive and anti-hypertensive measures with one overcoming the other based on the hour of the day. Non-pharmacological therapies, regarded as avoidance of precipitating factors and physical and dietary interventions, as well as chronic treatment revision, have a pivotal role.In this review we will discuss, in a pragmatic manner, about epidemiology, etiology, clinical aspects and diagnosis of orthostatic hypotension. Moreover, we will discuss about prognosis and management of orthostatic hypotension and supine hypertension.Heart failure (HF) is a syndrome with an uncertain definition for both contents and boundaries, with multiple components and clinical profiles, and treatments to which many HF patients do not respond.This article does not go through the guidelines, but it focuses on some clinically relevant points, in which research is active, to discuss them and, when possible, to make the point under a clinical cardiology vision.Aspects considered include (i) the concept of "definition"; (ii) HF with preserved or reduced ejection fraction; (iii) sudden death; (iv) briefly population genetics, polygenic risk scores and the OMICs; (v) atrial fibrillation ablation in HF (underlying inconsistency of international guidelines); (vi) the welcome rampant/crawling penetration of artificial intelligence in daily HF management.
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