Notes

Centrantheroside P oker, a new ionone glycoside coming from Centranthera grandiflora.
In current breast ultrasound computer aided diagnosis systems, the radiologist preselects a region of interest (ROI) as an input for computerised breast ultrasound image analysis. This task is time consuming and there is inconsistency among human experts. Researchers attempting to automate the process of obtaining the ROIs have been relying on image processing and conventional machine learning methods. We propose the use of a deep learning method for breast ultrasound ROI detection and lesion localisation. We use the most accurate object detection deep learning framework - Faster-RCNN with Inception-ResNet-v2 - as our deep learning network. Due to the lack of datasets, we use transfer learning and propose a new 3-channel artificial RGB method to improve the overall performance. We evaluate and compare the performance of our proposed methods on two datasets (namely, Dataset A and Dataset B), i.e. Amredobresib chemical structure within individual datasets and composite dataset. We report the lesion detection results with two types of analysis (1) detected point (centre of the segmented region or the detected bounding box) and (2) Intersection over Union (IoU). Our results demonstrate that the proposed methods achieved comparable results on detected point but with notable improvement on IoU. In addition, our proposed 3-channel artificial RGB method improves the recall of Dataset A. Finally, we outline some future directions for the research.Causal discovery is considered as a major concept in biomedical informatics contributing to diagnosis, therapy, and prognosis of diseases. Probabilistic causality approaches in epidemiology and medicine is a common method for finding relationships between pathogen and disease, environment and disease, and adverse events and drugs. Bayesian Network (BN) is one of the common approaches for probabilistic causality, which is widely used in health-care and biomedical science. Since in many biomedical applications we deal with temporal dataset, the temporal extension of BNs called Dynamic Bayesian network (DBN) is used for such applications. DBNs define probabilistic relationships between parameters in consecutive time points in the form of a graph and have been successfully used in many biomedical applications. In this paper, a novel method was introduced for finding probabilistic causal chains from a temporal dataset with the help of entropy and causal tendency measures. In this method, first, Causal Features Depwith unknown cause.Learning a Bayesian network is a difficult and well known task that has been largely investigated. To reduce the number of candidate graphs to test, some authors proposed to incorporate a priori expert knowledge. Most of the time, this a priori information between variables influences the learning but never contradicts the data. In addition, the development of Bayesian networks integrating time such as dynamic Bayesian networks allows identifying causal graphs in the context of longitudinal data. Moreover, in the context where the number of strongly correlated variables is large (i.e. oncology) and the number of patients low; if a biomarker has a mediated effect on another, the learning algorithm would associate them wrongly and vice versa. In this article we propose a method to use the a priori expert knowledge as hard constraints in a structure learning method for Bayesian networks with a time dependant exposure. Based on a simulation study and an application, where we compared our method to the state of the art PC-algorithm, the results showed a better recovery of the true graphs when integrating hard constraints a priori expert knowledge even for small level of information.
Two common issues may arise in certain population-based breast cancer (BC) survival studies I) missing values in a survivals' predictive variable, such as "Stage" at diagnosis, and II) small sample size due to "imbalance class problem" in certain subsets of patients, demanding data modeling/simulation methods.

We present a procedure, ModGraProDep, based on graphical modeling (GM) of a dataset to overcome these two issues. The performance of the models derived from ModGraProDep is compared with a set of frequently used classification and machine learning algorithms (Missing Data Problem) and with oversampling algorithms (Synthetic Data Simulation). For the Missing Data Problem we assessed two scenarios missing completely at random (MCAR) and missing not at random (MNAR). Two validated BC datasets provided by the cancer registries of Girona and Tarragona (northeastern Spain) were used.

In both MCAR and MNAR scenarios all models showed poorer prediction performance compared to three GM models the saturated one (GM.SAT) and two with penalty factors on the partial likelihood (GM.K1 and GM.TEST). However, GM.SAT predictions could lead to non-reliable conclusions in BC survival analysis. Simulation of a "synthetic" dataset derived from GM.SAT could be the worst strategy, but the use of the remaining GMs models could be better than oversampling.

Our results suggest the use of the GM-procedure presented for one-variable imputation/prediction of missing data and for simulating "synthetic" BC survival datasets. The "synthetic" datasets derived from GMs could be also used in clinical applications of cancer survival data such as predictive risk analysis.
Our results suggest the use of the GM-procedure presented for one-variable imputation/prediction of missing data and for simulating "synthetic" BC survival datasets. The "synthetic" datasets derived from GMs could be also used in clinical applications of cancer survival data such as predictive risk analysis.Nowadays, the demand for segmenting different types of cells imaged by microscopes is increased tremendously. The requirements for the segmentation accuracy are becoming stricter. Because of the great diversity of cells, no traditional methods could segment various types of cells with adequate accuracy. In this paper, we aim to propose a generic approach that is capable of segmenting various types of cells robustly and counting the total number of cells accurately. To this end, we utilize the gradients of cells instead of intensity for cell segmentation because the gradients are less affected by the global intensity variations. To improve the segmentation accuracy, we utilize the Gabor filter to increase the intensity uniformity of the gradient image. To get the optimal segmentation, we utilize the slope difference distribution based threshold selection method to segment the Gabor filtered gradient image. At last, we propose an area-constrained ultimate erosion method to separate the connected cells robustly.
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