Notes

Peripapillary Halo throughout -inflammatory Papillitis regarding Birdshot Chorioretinopathy.
We attempt to identify specific differentially methylated and expressed genes in people with longevity family history, it will contribute to discover significant features about human longevity.

A prevalence study was conducted during October 2017 to January 2019 in Bama County of Guangxi, China and individuals were recruited and grouped into longevity family (n=60) and non-longevity family (n=60) to identify differentially methylated genes (DMGs). The expression profile dataset GSE16717 was downloaded from the GEO database in which individuals were divided into 3 groups, namely longevity (n=50), longevity offspring (n=50) and control (n=50) for identifying differentially expressed genes (DEGs). It was considered significantly different when
or adjusted
≤0.05.

In total, 117 longevity-related hypermethylated genes enriched in interleukin secretion/production regulation, chemokine signaling pathway and natural killer cell-mediated cytotoxicity. Another 296 significant key longevity-related DEGs primarily involved in protein binding, nucleus, cytoplasm, T cell receptor signaling pathway and Metabolic pathway,
and PFKFB4 were found to be both methylated and downregulated in people with longevity family history.

Human longevity-specific genes involve in many immunity regulations and cellular immunity pathways,
and
show hypermethylated and suppressed status in people with longevity family history and might serve as longevity candidate genes.
Human longevity-specific genes involve in many immunity regulations and cellular immunity pathways, H19 and PFKFB4 show hypermethylated and suppressed status in people with longevity family history and might serve as longevity candidate genes.
(
) is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections.

Overall, 85
isolates were isolated from clinical and nasal hospitalized patients and health care workers (HCWs) in a burn unit and non-burn units in Isfahan from June 2016 and September 2016. Genes encoding penicillin-binding protein 2a
A) and adhesive surface proteins, including fibronectin-binding proteins (
,
), fibrinogen binding protein (
), laminin-binding protein(
), collagen binding protein (
), elastin binding protein
intracellular adhesion operon (
A and
D) were detected using PCR method.

The rate of methicillin-resistant
(MRSA) among burn and non-burn isolates were 62% (18/29) and 25% (14/56), respectively. The most prevalent MSCRAMMs genes in burn units were
(86%) and
(66%). The most common gene pattern in burn center was
A+
+
The frequency of
D,
and
S was higher in clinical samples than nasal samples. No relation was found between the MSCRAMMs genes in the burn unit and non-burn units.

The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of
D,
and
S in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of
.
The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of icaD, fib and ebpS in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of S. aureus.
The difference in serum 25-hydroxyvitamin D
(25-(OH) D
) level between the gestational diabetes mellitus (GDM) and healthy pregnant women was analyzed, to provide the experimental evidence for the vitamin supplement in pregnant women, especially those with GDM.

Pregnant women (n=50) who received prenatal care in the Obstetrical Clinic of Xuzhou Maternity and Child Health Care Hospital in summer and winter of 2016 were enrolled. They were assigned to the summer GDM group, winter GDM group, summer control group and winter control group. The level of serum 25-(OH)D
was determined using immunochromatography.

The mean level of serum 25-(OH)D
in pregnant women of four groups was lower than normal level. Compared with control group in corresponding season, the winter and summer GDM groups had significantly lower level of 25-(OH)D
than the winter and summer control groups (
<0.05). The winter GDM group had significantly lower level of 25-(OH)D
than the summer GDM group (
<0.05). The winter control group had significantly lower level of 25-(OH)D
than the summer control group (
<0.05). The percentage of deficient 25-(OH)D
level was the highest in winter GDM group. Vitamin D deficiency was severer in pregnant women with GDM than healthy pregnant women. In winter, vitamin D deficiency was severer than that in summer.

Pregnant women, especially those with GDM, should pay more attention to vitamin D supplementation.
Pregnant women, especially those with GDM, should pay more attention to vitamin D supplementation.
Rapid Health Impact Assessment (Rapid HIA) for Special Economic Zone (SEZ) has not been undertaken in Thailand. read more We aimed to develop a Rapid HIA model for policymaking by using Songkhla SEZ as a study model.

Four-stage of the research and development based on HIA process were used 1) drafting the model using literature reviews and focus group discussions, 2) collecting additional information from 24 stakeholders, and conducting an in-depth interview with six informants, 3) verifying the model by drawing agreements on the model from 17 related agencies and experts, and 4) confirming the validity of the final model using seven experts. The study were conducted from Jan 2018 to Feb 2019. Content analysis and constant comparison were used to analyze the data.

A four-step assessment model was obtained. They included public screening, scoping, assessing, and reviewing and influencing. Public screening is deduced from a meeting with organizations and related personnel. Public scoping is an outcome of literature reviewing and meeting with stakeholders and academics. The assessment step focuses on secondary data from related agencies and a participatory workshop with stakeholders and academics. Finally, a meeting with stakeholders and academics, including internet broadcasting, is the reviewing and influencing process.

This Rapid HIA model was specifically developed for SEZ policy. Reviewing and influencing steps were combined, whereas the monitoring and evaluation step was removed for further operations. This model depends on the official appointment of the steering committee. HIA practitioners should be experienced academics from higher educational institutions.
This Rapid HIA model was specifically developed for SEZ policy. Reviewing and influencing steps were combined, whereas the monitoring and evaluation step was removed for further operations. This model depends on the official appointment of the steering committee. HIA practitioners should be experienced academics from higher educational institutions.
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