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Long-Term Outcomes of Atrioventricular Valve Medical procedures in Patients along with Functional Individual Ventricle: Don't let Prevent Control device Alternative?
In this study, the translational trajectory of bubble in an ultrasonic standing wave at 22.4 kHz was observed using an imaging system with a high-speed video camera. This allowed the velocities of bubble be measured when the acoustic pressure at 20 kPa, 40 kPa and 60 kPa, which applied to indirectly measured the history force by using the acoustic and hydrodynamic forces balance model. It shown that bubbles driven at low acoustic pressure, the history force close to zero, and with the pressure increase the history force change to large, the ratio of FH/FQS from 0.33 at 40 kPa to 1.73 at 60 kPa, the result is different with prior research when the Reynolds numbers is large, and useful in the understanding of bubble moments in an acoustic field. Current models for calculating nonlinear power dissipation during the oscillations of acoustically excited bubbles generate non-physical values for the radiation damping (Drd) term for some frequency and pressure regions that include near resonance oscillations. Moreover, the ratio of the dissipated powers significantly deviate from the values that are calculated by the linear model at low amplitude oscillations (acoustic excitation pressure of PA=1 kPa and expansion ratio of less then ≊1.01). In high amplitude oscillation regimes (Pa⩾20 kPa), the dissipated power due to Drd deviates largely from the dissipated power as calculated by the widely accepted approach that uses the scattered power by the bubbles. We provide critical corrections to the present models. The validity of the results was examined in regimes of low amplitude oscillations and high amplitude oscillations. In the low amplitude regime, the ratio of the dissipated powers as calculated by the current and proposed model were compared with the linear model predictions. At higher amplitude oscillations, the dissipated power by radiation loss as calculated by the current and the proposed models were compared with the dissipated power calculated using the scattered power by the bubbles. We show that non-physical values are absent in the proposed model. Moreover, predictions of the proposed approach are identical to the predictions of the linear model and the dissipated power estimated using the scattered pressure by the bubble. We show that damping due to thermal effects, liquid viscosity and radiation heavily depend on the excitation pressure and that the linear model estimations are not valid even at pressures as low as 20 kPa. The synthesis of ZnO photocatalysts by ultrasound-assisted technique was here investigated. Several experimental parameters including the zinc precursor (acetate, chloride, nitrate), sonication conditions (amplitude, pulse) and post-synthetic thermal treatment (up to 500 °C) were studied. MC903 Crystalline ZnO samples were obtained without thermal treatments due to the adopted reactant ratios and synthesis temperature. Sonication plays a major role on the morphological oxide features in terms of particle size and surface area, the latter showing a 20-fold increase with respect to conventional synthesis. Interestingly, 1 and 3 s sonication pulses led to morphological properties similar to continuous sonication. A thermal treatment at moderate temperatures (400-450 °C) promoted the loss of surface hydroxylation and the formation of lattice defects, while higher temperatures were detrimental for the sample morphology. The prepared ZnO was decorated with WO3 particles comparing an ultrasound-assisted technique using 1 s pulses with a conventional approach, giving rise to composites with promoted visible light absorption. Samples were tested towards the photocatalytic degradation of nitrogen oxides (500-1000 ppb) in humidified air under both UV and visible light. By carefully controlling the synthetic procedure, better performance were observed with respect to the commercial benchmark. Samples from ultrasound-assisted syntheses, also in the case of pulsed sonication, showed consistently better results than conventional references, in particular for ZnO-WO3 composites. The composite by ultrasound-assisted synthesis showed > 95% degradation in 180 min and doubled NOx degradation under visible light with respect to the conventional composite. PURPOSE Use of autophagy inhibitors in combination with chemotherapy has become a novel chemotherapeutic strategy. In this study, we aimed to determine whether the effectiveness of doxorubicin (DOX) is augmented by clarithromycin (CAM) in MCF7 cells and the molecular mechanisms involved. MATERIALS AND METHODS Combined cytotoxicity of CAM and DOX was assessed by MTT assay and was analyzed using the Chou-Talalay's method. To clarify the underlying mechanisms, several factors, including apoptosis (Annexin V/propidium iodide staining), intracellular level of DOX (spectrofluorimetry) and P-glycoprotein activity (Rhodamin 123 efflux assay) were measured. In addition, autophagy was evaluated by intracellular labeling with anti-LC3II and LysoTrackerGreen (LTG) staining and analyzed by flowcytometry. RESULTS The anti-proliferation effect of DOX was synergistically enhanced by CAM in MCF7 cells and was associated with an increase in the apoptotic cell death. However, the intracellular level of DOX remained unchanged in the presence of CAM. Based on the findings, 100 μM of CAM did not exhibit any inhibitory effects on P-glycoprotein activity. Flow cytometric analysis indicated that DOX at IC20 concentration induced the autophagy flux, as confirmed by the increased level of LC3II and LTG signals. Moreover, combined treatment with DOX and CAM resulted in more pronounced LTG signals, but no change in LC3II. These results indicate that CAM blocks the autophagy flux induced by DOX. CONCLUSIONS These findings suggest that suppression of autophagy by CAM may promote chemotherapeutic outcome in breast cancer. However, further investigations are needed to evaluate the application of CAM in adjuvant breast cancer therapy. V.AIM To evaluate BreastSurgANZ members' compliance at various threshold rates for 4 evaluable High-Quality Performance Indicators (HQPIs) introduced to improve patient care. To benchmark global best practice to assist in determining the eventual threshold standards. METHOD BreastSurgANZ Quality Audit data 2012-2016 & 2018 was used to determine rates of attainment through a range of thresholds for 4 HQPI's. Rates were assessed for different volume surgeons and comparison made to international standards. RESULTS 1.3761 patients needing mastectomy for in situ disease, if the threshold rate for immediate breast reconstruction (IBR) was ≥ 40% then 30% of all members and 78% of very high-volume surgeons achieved that rate, which is comparable to international recommendations. 2.26,007 patients requiring mastectomy, if the threshold rate for IBR was ≥ 20% then 28% of all surgeons and 78% very high-volume surgeons met the standard. This is below most international recommendations. 3. For 31,698 invasive tumours ≤ 2 cm, if the threshold rate for breast conservation was ≥ 70% then 64% of all surgeons met the standard; 70% is comparable internationally.
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