Notes

Earlier indications of pneumoconiosis in the dental care professional inside Italia: in a situation record.
Di-(2-ethylhexyl) phthalic acid (DEHP) is the most extensively practiced plasticizer compound and a representative endocrine disrupting pollutant. Recently, the environmental impact and toxicological causes of DHEP on human health have been extensively investigated. DEHP uptake by plants is most significant biotransformation process of DEHP in environment. In this study, Helianthus annuus (H.annuus), vastly efficient in phytoremediation of polluted soil was selected to study the uptake and phytoremediation of DEHP in contaminated soil. In CP-91149 , the effect of citric acid on enhanced uptake and removal of DEHP was also investigated. The orders of biomass concentrations showed in the CA treatments were 200 mM (60.5 g) ˃ 150 mM (54.5) ˃ 100 mM (50.2 g) ˃ 50 mM (46.5 g). The maximum shoot accumulation of DHEP (20 mg/kg) was observed at 200 mM citric acid treatment compared to all other treatments (50, 100, and 150 mM). Significant difference of the antioxidant enzymes activity (CAT, 25.7, POD, 22.5 (μmol H2O2/min/g FW) and COD 5.6 U/g FW) was observed between control and CA treatments as well as different concentrations of CA treated plants. The maximum ALP (0.17 mg.g-1soil.24 h-1) and urease activities (1.65 mg.g-1soil.24 h-1) were observed at 200 mM CA amended soils. The application of citric acid was significantly enhanced the H.annuus growth as well as uptake of DEHP. The results explored that the citric acid has excellent potential for the enhanced uptake of DEHP in contaminated soil.Lead (Pb) is a commonly found heavy metal due to its historical applications. Recent studies have associated early-life Pb exposure with the onset of various neurodegenerative disease. The molecular mechanisms of Pb conferring long-term neurotoxicity, however, is yet to be elucidated. In this study, we explored the persistency of alteration in epigenetic marks that arise from exposure to low dose of Pb using a combination of image-based and gene expression analysis. Using SH-SY5Y as a model cell line, we observed significant alterations in global 5-methycytosine (5 mC) and histone 3 lysine 27 tri-methylation (H3K27me3) and histone 3 lysine 9 tri-methylation (H3K9me3) levels in a dose-dependent manner immediately after Pb exposure. The changes are partially associated with alterations in epigenetic enzyme expression levels. Long term culturing (14 days) after cease of exposure revealed persistent changes in 5 mC, partial recovery in H3K9me3 and overcompensation in H3K27me3 levels. The observed alterations in H3K9me3 and H3K27me3 are reversed after neuronal differentiation, while reduction in 5 mC levels are amplified with significant changes in patterns as identified via texture clustering analysis. Moreover, correlation analysis demonstrates a strong positive correlation between trends of 5 mC alteration after differentiation and neuronal morphology. Collectively, our results suggest that exposure to low dose of Pb prior to differentiation can result in persistent epigenome alterations that can potentially be responsible for the observed phenotypic changes. Our work reveals that Pb induced changes in epigenetic repressive marks can persist through neuron differentiation, which provides a plausible mechanism underlying long-term neurotoxicity associated with developmental Pb-exposure.It has not been well understood that the influences of pH and accompanying anions on the toxicity of selenate (Se(VI)). The influences of pH and major anions on Se(VI) toxicity to wheat root elongation were determined and modeled based on the biotic ligand model (BLM) and free ion activity model (FIAM) concepts. Results showed that EC50[Se(VI)]T values increased from 162 to 251 μM as the pH values increased from 4.5 to 8.0, indicating that the pH increases alleviated the Se(VI) toxicity. #link# The EC50SeO42- values increased from 133 to 203 μM while the EC50HSeO4- values sharply decreased from 210 to 0.102 nM with the pH increasing from 4.5 to 8.0. The effect of pH on Se(VI) toxicity could be explained by the changes of Se(VI) species in different pH solutions as SeO42- and HSeO4-were differently toxic to wheat root elongation. The toxicity of Se(VI) decreased with the increasing activities of H2PO4- and SO42- but not for NO3- and Cl- activities, indicating that only H2PO4- and SO42- had competitive effects with Se(VI) on the binding sites. An extended BLM was developed to consider effects of pH, phosphate and sulphate, and stability constants of SeO42-, HSeO4-, H2PO4- and SO42- to the binding sites were obtained log [Formula see text] = 3.45, log [Formula see text] = 5.98, log [Formula see text] = 2.05, log [Formula see text] = 1.85. Results implied that BLM performed much better than FIAM in the wheat root elongation prediction when coupling with toxic species SeO42- and HSeO4-, and the competitions of H2PO4- and SO42- for the binding sites while developing the Se(VI)-BLM.The current study aims to assess the pollution status of the European river-sea system lower Danube River-Danube Delta-North West Black Sea, through an integrated analysis of metal concentrations in water, sediments and fish community. The Danube flows through numerous industrial cities and receives a significant amount of pollutants due to the reception of urban and industrial emissaries, as well as agricultural land runoff. Samples of water, sediments and fish (10 species) were collected from 7 representative sites along Danube River, Danube Delta and Black Sea shore. For the analysed fish species, potentially toxic and essential elements (Pb, Cd, As, Cu, Fe, Zn, Mg, Ca, Na, K) from muscle and liver samples were measured and discussed. Measurement of elements and other environmental quality parameters were determined for water and sediments. The Black Sea area, represented by S6 and S7, received sediments from Danube with the lowest concentrations of Cd (0.05 ± 0.01 μg g-1, respectively 0.01 ± 0.001 μg g-1)was confirmed by several other studies.In forest ecosystems, forest litter is considered an active medium for radiocesium (137Cs). To understand discharge mechanisms of highly bioavailable dissolved 137Cs from forests to river systems, we investigated the characteristics of 137Cs leaching from forest litter as observed from litterbag experiments. Leaching experiments with conifer needle and deciduous broadleaf litters were then conducted. After soaking conifer needles and broadleaf litters for 20 min, 140 min, and 1 day, the mean values of the 137Cs leaching ratios were 0.13-2.0% and 0.81-6.6%, respectively, indicating that 137Cs leaching ratios are different between forest litter types. To elucidate the factors affecting 137Cs leaching from forest litter, a multi-regression analysis of 137Cs leaching ratios was conducted against antecedent mean precipitation and temperature before sampling the litterbag and accumulated temperature during the litterbag experiments. The 137Cs leaching ratios showed a negative correlation to the antecedent mean precipitation for both litters and the accumulated temperature for broadleaf litters, whereas it exhibited a positive correlation with the antecedent mean temperature for both litters and the accumulated temperature for conifer needle litters.
Website: https://www.selleckchem.com/products/cp-91149.html