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Researching the actual organization involving cardio medical care along with blood pressure as well as duration of remain involving in-patients together with coronary heart inside Wuhan, Cina.
Multivariate survival analysis identified a GPS of 1 or 2 (hazard ratio, 3.520; 95% confidence interval, 1.343-9.227; p = 0.010) and a high CA125 level (hazard ratio, 3.135; 95% confidence interval, 1.276-7.697; p = 0.013) as significant independent predictors associated with a poorer prognosis in the studied group of cancer patients. CONCLUSIONS A GPS of 1 or 2 and a high level of CA125 are independent predictors of a poorer prognosis in patients receiving chemotherapy for recurrent gastric cancer. © 2020 S. Karger AG, Basel.PURPOSE To assess whether open and closed vitrification protocols are equally effective for sibling-oocyte cycles when performing blastocyst embryo transfers. MATERIALS AND METHODS A prospective study was set up comparing the open and the closed vitrification techniques in oocyte recipients sharing sibling oocytes between 2014 and 2016. Sibling oocytes were randomly and equally assigned into the closed group (oocytes vitrified in a closed system) or the open group (oocytes vitrified in an open system). Intracytoplasmic sperm injection was performed on all cases. Embryo transfers were performed on day 5. Power analysis calculation showed that 94 cycles would be needed for each group in the study in order to achieve statistical significance at a 5% level with power 80%. RESULTS The final number of donors included was 95. A total of 190 recipients matched with their donors were included in the study. There was no difference in the mean number of oocytes vitrified with the closed or the open system (8.26 ± 2.54 vs. 8.31 ± 2.57). No significant difference was observed between the 2 groups regarding survival rate, fertilization rate, cleavage rate, top-quality embryos on day 3, blastocyst rate, and top-quality blastocyst rate. Moreover, no statistically significant difference in the b-human chorionic gonadotropin-positive rate, clinical pregnancy rate per cycle, implantation rate, ongoing pregnancy rate, and live birth rate between closed and open groups. CONCLUSION Οpen and closed vitrification protocols are equally effective for sibling-oocyte cycles. © 2020 S. Karger AG, Basel.BACKGROUND The Oncotype DX® (ODX) is a genomic assay that provides clinicians with a prediction of benefit of chemotherapy in node-negative, tamoxifen-treated breast cancer. However, the relationship between ODX recurrence score (RS) and diabetes, a common comorbidity in breast cancer patients, has been inadequately described in the literature. Specifically, the association of diabetes treatment with metformin and RS is inconclusive, with different studies reporting conflicting results. Because diabetes has been associated with higher RS, it has been suggested that management of diabetes with metformin in breast cancer patients may be associated with a lower RS. OBJECTIVES We studied a large cohort of early-stage, hormone-positive breast cancer patients to determine if there is an association between RS and metformin treatment. METHODS In this study, we retrospectively examined the medical records of 514 early-stage, hormone-positive breast cancer patients who had oncotype testing performed between 2007 and 2017. Number (%) or median were used to describe the patients' characteristics between groups and were compared by the Kruskal-Wallis test at a significance level of 5%. RESULTS Of this cohort, 67 (13%) had a diabetes diagnosis at the time of breast cancer diagnosis, including both diabetes mellitus and pre-diabetes. The median RS for non-diabetic patients was 16 and the median RS for diabetic patients was 15. This difference was not significant, nor was there a statistical difference in RS between diabetic patients taking metformin (median RS = 15) and diabetic patients not taking metformin (median RS = 15). selleck chemical These results held true even when controlling for BMI. CONCLUSIONS We conclude that neither diabetes diagnosis nor metformin use is associated with a difference in oncotype RS in this population of diabetic patients. © 2020 S. Karger AG, Basel.BACKGROUND AND AIMS Food frequency questionnaires (FFQ) have been widely used in epidemiologic studies since 1990s, but instruments need to be validated. The aim of this work was to create and assess the validity and reproducibility of an interview administered FFQ to be used in a Mexican women's bone health cohort study, located in Monterrey city, Mexico. METHODS Validation of FFQ formed by 11 food groups and 136 food and beverage items was performed on 40-65-year-old Mexican women (n = 200) by applying 2 FFQ (test method) and six 24-h dietary recalls (24hR, reference method; 1 per season on weekdays and 2 on weekends). Pearson correlation coefficient was calculated of both logs, transformed intakes and energy-adjusted nutrient intakes based on the residual method, and intraclass correlation coefficients were calculated. RESULTS The relative validity of FFQ against the average of six 24hR for intakes of energy, macronutrients, cholesterol, water, vitamins and minerals required for bone metabolism such as vitamin D, calcium, magnesium, phosphorus were obtained. Pearson coefficients of correlation show significance (p less then 0.05) for the validity, 0.244-0.820 and 0.258-0.794, for energy-unadjusted and adjusted data, respectively. Reproducibility coefficients range 0.186-0.810 for energy-unadjusted data and 0.174-0.597 for energy-adjusted data. Most nutrients showed lower than 5% of misclassification. CONCLUSION The designed 136-item FFQ shows acceptable validity and reproducibility, and it is useful to be applied on 40-65-year-old Mexican women for the estimation of nutrient intakes in epidemiological studies. © 2020 S. Karger AG, Basel.INTRODUCTION Colposcopy represents the second step of the diagnostic approach of cervical intraepithelial lesions. Limits of colposcopy in studying cervix are essentially related to cervical anatomy. Nowadays, endocervical courettage is the standard technique to examine endocervix. Endocervicoscopy is a new imaging technique for the diagnostic work-up of endocervix in patients with cervical intraepithelial neoplasia (CIN). OBJECTIVE To evaluate endocervicoscopy accuracy to identify and grade cervical intraepithelial lesion in comparison to other procedures employed into the diagnostic workup of cervical pathology. METHODS A total of 634 women who performed colposcopy, endocervicoscopy and cytological or histological sampling were included in a retrospective study. The agreement between the endocervicoscopic and the colposcopic impressions, minor and major changes, and between these imaging techniques and histological diagnosis was assessed for the entire cohort. χ2 test and k statistic were used in the statistical analysis.
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