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Rhododendron molle Grams. Wear Remove Induces Apoptosis and also Prevents Migration within Man Intestinal tract Most cancers Tissue along with Potential Anticancer Components Investigation.
Polycyclic aromatic hydrocarbons (PAHs) are byproducts of incomplete combustion reactions and are ubiquitous in the environment, leading to widespread human exposure via inhalation and ingestion pathways. PAHs have been implicated as endocrine disrupting compounds in previous animal and in vitro studies, but human studies are currently lacking. Pregnant women and their developing fetuses are particularly susceptible populations to environmental contaminants, in part because alterations in hormone physiology during gestation can have adverse consequences on the health of the pregnancy. We utilized data on 659 pregnant women from the PROTECT longitudinal birth cohort in Puerto Rico to assess associations between repeated measures of 8 urinary hydroxylated PAH (OH-PAH) metabolites and 9 serum hormones during gestation. Urine samples were collected at 3 study visits (median gestational ages of 18, 22, and 26 weeks at each visit, respectively) and serum samples were collected at the first and third study visits. Linear mixed effects models were used to ascertain longitudinal associations between OH-PAHs and hormones, and sensitivity analyses were employed to assess potential nonlinearity and differences in associations on the basis of fetal sex and timing of biomarker measurement. Among the multiple positive associations we observed between OH-PAHs and CRH, estriol, progesterone, T3, and the ratio of T3 to T4, and inverse associations with testosterone, the most notable are a 24.3% increase (95% CI 13.0, 36.7) in CRH with an interquartile range (IQR) increase in 1-hydroxyphenanthrene and a 17.2% decrease (95% CI 8.13, 25.4) in testosterone with an IQR increase in 1-hydroxynapthalene. Many associations observed were dependent on fetal sex, and some relationships showed evidence of nonlinearity. These findings demonstrate the importance of studying PAH exposures during pregnancy and highlight the potential complexity of their impacts on the physiology of human pregnancy.Freshwater products consumed in the diet are among the major sources of exposure of humans to polycyclic aromatic hydrocarbons (PAHs). In this study, eight freshwater organisms and environmental samples were collected from Chaohu Lake, the fifth-largest lake in China. The levels of PAHs in the collected organisms were measured using GC-MS. Tissue distribution characteristics in three fish species were studied. Relationship between residual levels and environment concentrations were analyzed and bioaccumulation effect and influencing factors were identified. Finally, the potential carcinogenic risk of aquatic product intake was estimated. The concentrations of ΣPAHs in aquatic organisms varied from 18.4 to 398 ng/g, with a mean value of 157 ± 125 ng/g. For carp, the highest ΣPAHs level was detected in the brain with concentration of 591 ng/g. For topmouth culter, and bighead fish, the organs with the greatest ΣPAHs concentration were gills (440 ng/g) and muscles (200 ng/g), respectively. Significant correlations were found between the PAH content in environment media including water, SPM, sediment and PAH content in aquatic animals. The calculation of food web magnification factors and risk assessment indicates that although the PAH concentration diluted with the increase of the trophic level, PAHs exposure through the aquatic products intake still poses potential carcinogenic risk. The incremental lifetime cancer risk values were 7.68 × 10-6 and 4.75 × 10-6 in urban and rural populations, respectively.Understanding the different scales of temporal variability is crucial to improve the knowledge of the biogeochemical processes in the land-ocean interface. In this study, we evaluated the role of continental runoff and intrusion of oceanic water masses in the trophic state of the Bay of Santa Catarina Island (BSCI) over the last three decades (1993-2019) by using multiple biogeochemical and eutrophication assessment tools. The sub-watersheds of BSCI showed high concentrations of nutrients, fecal coliform and chlorophyll-a, directly correlated to the number of inhabitants. Worst-case scenarios were found in summer and fall seasons due to sewage inputs caused by mass tourism and the inefficiency or even absence of treatment systems, boosted by strong rainfall. The intrusion of the South Atlantic Central Water and the Plata Plume Water into the BSCI favored autotrophy in the summer and heterotrophy in the winter, coupled with low and high residence time, respectively. El Niño events enhanced rainfall and continental runoff, exporting elevated nutrients and phytoplankton biomass loads from the eutrophic rivers to the continental shelf. The pattern reverses during La Niña, when chlorophyll and nutrient peaks were detected inside the bay. Eutrophication evaluation indicated that the trophic state oscillated from moderate to high and that these conditions tend to remain the same in future scenarios due to the moderate residence time of the water, anthropogenic pressures, periodic algal blooms and the intrusion of nutrient-rich oceanic water masses. 3,4-Dichlorophenyl isothiocyanate compound library chemical Management actions, such as the improvement of the wastewater treatment system and wetlands restoration, are needed in order to mitigate eutrophication and the loss of ecosystem services and functions.Diffuse pollution formed during a surface runoff on paved surfaces is a source of heavy metals (HMs) of various origin. This research study indicates the connection between bottom sediments of retention tanks located on urban streams and road sweeping wastes (RSW) that migrate during surface runoff to the stormwater drainage systems with discharge to the retention tanks. Moreover, we test the primary sources of HMs in RSW by analysing the mechanical wastes (MW) produced by vehicles in order to track the relationship between car parts and HMs deposited in the retention tanks receiving the surface runoff from streets. To identify the origin of HMs diverse source tracking approaches were used statistical methods, Pb isotope ratios, and the flag element ratio approach. MW presented a very high HMs content (max observed values in mg/kg d.w. 10477-Zn, 3512-Cu, 412-Pb, 3.35-Cd, 226-Ni, and 633-Cr), while for RSW the HMs content was similar to the bottom sediments. The total carcinogenic risk raises concerns due to the Cr content.
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