Notes

Included analysis regarding Whole genome sequencing as well as lifetime review regarding polyhydroxyalkanoates generation by simply Cupriavidus sp. ISTL7.
Based on the origin of the food enzyme from edible parts of animals, the data provided by the applicant, supported by the evaluation of clinical studies with pharmaceutical preparations based on pancreatic enzymes, the Panel concluded that the porcine pancreatic enzymes do not give rise to safety concern under the intended conditions of use.The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase EC 3.1.1.3) is produced with a genetically modified Aspergillus niger strain NZYM-DB by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The food enzyme is intended to be used in an immobilised form in the production of modified fats and oils by interesterification. Based on the estimated use levels recommended for interesterification of fats and oils and individual data from the EFSA Comprehensive European Food Database, dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 0.75 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose of 1,132 mg TOS/kg bw per day, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 1,500. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood of such reactions to occur is likely to be low. Based on the data provided, the immobilisation of the food enzyme and the removal of total organic solids during fats and oils processing, the Panel concluded that the food enzyme does not give rise to safety concerns under the intended conditions of use.The food enzyme cellulase (4-(1,3;1,4)-β-d-glucan 4-glucanohydrolase; EC 3.2.1.4) is produced with the non-genetically modified Penicillium funiculosum strain Lzc35 by Danisco US Inc. The cellulase is intended to be used in distilled alcohol production, baking and brewing processes. Since residual amounts of total organic solids (TOS) are removed by distillation, dietary exposure was only calculated for baking and brewing processes. Based on the proposed maximum use levels, dietary exposure to the food enzyme-TOS was estimated to be up to 0.416 mg TOS/kg body weight (bw) per day. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 84 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 200. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.The EFSA Panel on Plant Health performed a pest categorisation of Diaphorina citri (Hemiptera Liviidae) (Asian citrus psyllid) for the EU. D. citri is a key pest of citrus in several countries as it is a vector of serious bacterial pathogens, the putative causal agents of Huanglongbing (HLB) also known as citrus greening. Eggs are laid on tips of growing shoots on and between unfurling leaves. Females may lay more than 800 eggs during their lives. Nymphs pass through five instars. The life cycle requires from 14 to 49 days, depending upon the season. There is no diapause, but populations are low in winter. It overwinters as an adult which may live for several months. The species completes 9-10 generations/year; however, under protected conditions, up to 16 generations have been recorded. Commission Implementing Regulation (EU) 2019/2072 (Annex IIA) regulates D. citri, as a quarantine pest not known to occur in the EU territory. Fruits and plants for planting provide potential pathways for entry into the EU. Climatic conditions and the availability of host plants provide conditions to support establishment in the EU. The introduction of D. citri would have an economic impact in the EU through direct but mainly indirect effects due to potential transmission of HLB. Phytosanitary measures are available to reduce the likelihood of entry. D. citri satisfies the criteria that are within the remit of EFSA to assess for it to be regarded as a potential Union quarantine pest. D. citri does not meet the criteria of occurring in the EU, nor plants for planting being the principal means of spread, for it to be regarded as a potential Union regulated non-quarantine pest.This guidance document is intended to assist the applicant in the preparation and the presentation of an application, as foreseen in Article 7.6 of Regulation (EC) No 1831/2003, for the renewal of the authorisation of additives for use in animal nutrition. [Table see text].The Covid-19 pandemic dramatically disrupted the functionning and the organization of hospitals, notably the clinical departments and the biology laboratories. Moreover, this pandemic led to sudden impact in the management of tissue and cytological samples by pathology laboratories and biobanks. The consequences concerned the urgent mandatory setting up of sanitary measures adapted to these laboratories. DOTAP chloride manufacturer Another consequence was to note a strong decrease of the different activities in pathology laboratories and biobanks. So, in this context, the health workers in pathology laboratories and biobanks had to organize their laboratories according to the international guidelines for sanitary measures, aiming to keep going to take care of clinical and molecular diagnoses too. This review adresses the main consequences induced by the Covid-19 pandemic in pathology laboratories and in biobanks and some of the different actions took by these laboratories in order to maintain their activity during this crisis period.
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