Notes

PLAZA 5.3: stretching out the scope and also energy relative and also well-designed genomics in vegetation.
Our results exemplify that rapid uptake of salient prosodic features allows listeners to make online predictions about the speaker's ironic intent. This process can constrain their representation of an utterance to uncover nonliteral meanings without violating contextual expectations held about the speaker, as described by parallel-constraint satisfaction models.Overgeneralized fear (OGF), or indiscriminate fear responses to signals of threat and nonthreat, is a well-studied cognitive mechanism in human anxiety. Anxiety-related OGF has been studied primarily through fear-learning paradigms and conceptualized as overly exaggerated learning of cues signaling imminent threat. However, the role of safety learning in OGF has not only received much less empirical attention but has been fundamentally conceptualized as learning about the absence of threat rather than the presence of safety. As a result, the relative contributions of exaggerated fear learning and weakened safety learning to anxiety-related OGF remain poorly understood, as do the potentially unique biological and behavioral underpinnings of safety learning. The present review outlines these gaps by, first, summarizing animal and human research on safety learning related to anxiety and OGF. Second, we outline innovations in methods to tease apart unique biological and behavioral contributions of safety learning to OGF. Lastly, we describe clinical and treatment implications of this framework for translational research relevant to human anxiety.Prospective memory (PM) involves remembering to perform an intended action in the future. Researchers have demonstrated that, under certain conditions, contextual information about when PM performance opportunities are likely to occur can support PM performance while decreasing the cognitive demands of the PM task. The current study builds upon prior work to investigate whether warning participants that a PM-relevant context was approaching would improve the efficiency of PM control processes and benefit PM accuracy. Participants completed an ongoing lexical decision task with an embedded PM task of responding to a target syllable. For context conditions, targets only appeared on trials where letter strings were colored red (PM-relevant context), while PM-irrelevant trials were green. The warning in Experiment 1 was embedded in the ongoing task (trials preceding PM-relevant contexts were colored yellow). In Experiment 2 the warning was separate from the ongoing task (1-s pre-trial red fixation preceding PM-relevant contexts). Context improved PM control efficiency and PM accuracy in both experiments. Context always improved PM accuracy for targets in the second and third trial positions of PM-relevant contexts; however, only the Experiment 2 warning generated an accuracy benefit for targets in the first trial position. Experiment 3 replicated the findings of Experiments 1 and 2 and also confirmed that color change without associated context was not responsible for the current results.As naturally occurring examples of folk culture and creativity, internet memes provide a rich testbed to examine the interrelationships among cognitive and motivational factors that influence their impact. selleck chemical In two studies with participants recruited over the internet, we measured a variety of appraisals of both apolitical and political memes with a focus on the role of metaphorical aptness and personal relatability as predictors of comprehensibility and humor. Structural equation modeling was used to analyze interconnections among appraisals. A major network path connects relatability to aptness, which in turn is linked to appraisals of comprehensibility, humor, and propensity to share. For political memes, the congruity of the meme with the person's political position (liberal or conservative) has a powerful but indirect impact on the propensity to share it. These findings indicate that appraisals of memes are based on cognitive and motivational processes that also underlie metaphor comprehension and appreciation of humor.Investment in reproduction is predicted to accelerate ageing, but the link between reproductive investment and lifespan can be sex- and context-specific. In mammals, female reproductive costs are linked to pregnancy and lactation, but in males substantial reproductive allocation is required for a range of pre- and post-copulatory reproductive traits. Such traits include male-specific increased body size, olfactory signalling and territory defence-traits often expressed under androgen-dependent control. In this experimental study, we explored how reproduction influences lifespan in male mice, contrasting this to the established lifespan costs of reproduction in females. In a 2 × 2 factorial design, we gave either castrated or intact males (factor 1) access to a female or a male cage-mate across their entire life (factor 2). Neither castration nor access to females influenced median lifespan in male mice, but maximal lifespan was increased by either castration or reproduction when compared to intact males housed in male groups (standard male housing conditions). In females, mating significantly reduced lifespan, and while both sexes had similar lifespans in non-reproductive environments, males had a much longer lifespan when allowed mating. This data highlights the sex-specific nature of social environments and reproduction on lifespan, and the role of these conditions in promoting sexual dimorphism in ageing.Young-onset and late-onset Alzheimer's disease has different clinical presentations with late-onset presenting most often with memory deficits while young-onset often presents with a non-amnestic syndrome. However, it is unknown whether there are differences in presentation and progression of neuropsychiatric symptoms in young- versus late-onset Alzheimer's disease. We aimed to investigate differences in the prevalence and severity of neuropsychiatric symptoms in patients with young- and late-onset Alzheimer's disease longitudinally with and without accounting for the effect of medication usage. Sex differences were also considered in these patient groups. We included 126 young-onset and 505 late-onset Alzheimer's disease patients from National Alzheimer's Coordinating Center-Uniform Data Set (NACC-UDS) and Alzheimer's Disease Neuroimaging Initiative (ADNI). We investigated the prevalence and severity of neuropsychiatric symptoms using the Neuropsychiatric Inventory-Questionnaire over 4 visits with 1-year intervals, using a linear mixed-effects model.
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