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Improved understanding of the mechanisms by which miRNAs regulate drug resistance should facilitate the development of effective combination therapies for ovarian cancer.Candida auris is an emerging multidrug-resistant yeast causing nosocomial infections and associated with high mortality in immunocompromised patients. Rapid identification and characterisation are necessary for diagnosis and containing its spread. In this study, we present a selective culture medium for all C. auris clades. This medium is sensitive with a limit of detection ranging between 101 and 102 CFU/mL. The 100% specificity of SCA (specific C. auris) medium is confirmed on a set of 135 Candida strains, 50 bacterial species and 200 human stool samples. Thus, this medium specifically selects for C. auris isolation from clinical samples, allowing the latter to study its phenotypic profile.Ungulates are a group of hoofed animals that have long interacted with humans as essential sources of food, labor, clothing, and transportation. These consist of domesticated, feral, and wild species raised in a wide range of habitats and biomes. Given the diverse and extreme environments inhabited by ungulates, unique adaptive traits are fundamental for fitness. learn more The documentation of genes that underlie their genomic signatures of selection is crucial in this regard. The increasing availability of advanced sequencing technologies has seen the rapid growth of ungulate genomic resources, which offers an exceptional opportunity to understand their adaptive evolution. Here, we summarize the current knowledge on evolutionary genetic signatures underlying the adaptations of ungulates to different habitats.The thymus gland is a primary lymphoid organ for T-cell development. Various viral infections can result in disturbance of thymic functions. Medullary thymic epithelial cells (mTECs) are important for the negative selection of self-reactive T-cells to ensure central tolerance. Insulin-like growth factor 2 (IGF2) is the dominant self-peptide of the insulin family expressed in mTECs and plays a crucial role in the intra-thymic programing of central tolerance to insulin-secreting islet β-cells. Coxsackievirus B4 (CVB4) can infect and persist in the thymus of humans and mice, thus hampering the T-cell maturation and differentiation process. The modulation of IGF2 expression and protein synthesis during a CVB4 infection has been observed in vitro and in vivo in mouse models. The effect of CVB4 infections on human and mouse fetal thymus has been studied in vitro. Moreover, following the inoculation of CVB4 in pregnant mice, the thymic function in the fetus and offspring was disturbed. A defect in the intra-thymic expression of self-peptides by mTECs may be triggered by CVB4. The effects of viral infections, especially CVB4 infection, on thymic cells and functions and their possible role in the pathogenesis of type 1 diabetes (T1D) are presented.This paper proposes a highly sensitive surface plasmon resonance (SPR) refractive index sensor based on the photonic crystal fiber (PCF). The optical properties of the PCF are investigated by modulating the refractive index of a liquid analyte. The finite element method (FEM) is used to calculate and analyze the PCF structure. After optimization, the fiber can achieve high linearity of 0.9931 and an average refractive index sensitivity of up to 14,771.4 nm/RIU over a refractive index range from 1.47 to 1.52, with the maximum wavelength sensitivity of 18,000.5 nm/RIU. The proposed structure can be used in various sensing applications, including biological monitoring, environmental monitoring, and chemical production with the modification and analysis of the proposed structure.In this work, a 6-pass hot-rolling process followed by air cooling is studied by means of a coupled multi-scale simulation approach. The finite element method (FEM) is utilized to obtain macroscale thermomechanical parameters including temperature and strain rate. The microstructure evolution during the recrystallization and austenite (γ) to ferrite (α) transformation is simulated by a mesoscale cellular automaton (CA) model. The solute drag effect is included in the CA model to take into account the influence of manganese on the γ/α interface migration. The driving force for α-phase nucleation and growth also involves the contribution of the deformation stored energy inherited from hot-rolling. The simulation renders a clear visualization of the evolving grain structure during a multi-pass hot-rolling process. The variations of the nonuniform, deformation-stored energy field and carbon concentration field are also reproduced. A detailed analysis demonstrates how the parameters, including strain rate, grain size, temperature, and inter-pass time, influence the different mechanisms of recrystallization. Grain refinement induced by recrystallization and the γ→α phase transformation is also quantified. The simulated final α-fraction and the average α-grain size agree reasonably well with the experimental microstructure.A novel three-dimensional graphene-like networks material (3D-GLN) exhibiting the hierarchical porous structure was fabricated with a large-scale preparation method by employing an ion exchange resin as a carbon precursor. 3D-GLN was first studied as the effective microwave absorbing material. As indicated from the results of the electromagnetic parameter tests, and the minimum reflection loss (RL) of the 3D-GLN reached -34.75 dB at the frequency of 11.7 GHz. To enhance the absorption performance of the nonmagnetic 3D-GLN, the magnetic Fe3O4 nanoparticles were loaded on the surface of the 3D-GLN by using the hydrothermal method to develop the 3D-GLN/Fe3O4 hybrid. The hybrid exhibited the prominent absorbing properties. Under the matching thickness of 3.0 mm, the minimum RL value of hybrid reached -46.8 dB at 11.8 GHz. In addition, under the thickness range of 2.0-5.5 mm, the effective absorption bandwidth (RL less then 10 dB) was 13.0 GHz, which covered part of the C-band and the entire X-band, as well as the entire Ku-band. The significant microwave absorption could be attributed to the special 3D network structure exhibited by the hybrid and the synergistic effect exerted by the graphene and the Fe3O4 nanoparticles. As revealed from the results, the 3D-GLN/Fe3O4 hybrid could be a novel microwave absorber with promising applications.
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