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The text of DSM-5 includes a new heading-Suicide Risk-meant to educate users about the suicide risk posed by specific mental disorders. But, how well do the Suicide Risk sections fulfill their didactic intent? A review of the sections shows that topical coverage is uneven, noteworthy disorders are omitted, and there are inaccurate statements. In addition, the text frequently uses pejorative terms for suicidal behavior and self-injury. Although the DSM-5 Task Force should be lauded for giving concentrated attention to psychiatry's most lethal outcome, DSM-5 has limited utility for educating students about the suicide risk posed by mental disorders. I make four recommendations to improve the manual's focus on suicide risk and redress the use of stigmatizing terminology.Contamination levels of copper (Cu) and other heavy metals are very high in the soils of the abandoned copper mine of Lasail in the north western Hajar Mountains of Oman. Environment-friendly approaches such as phytoremediation are needed to clean and rehabilitate these areas to their natural status. In the present study, the phytoremediation potential of castor, Ricinus communis L., was evaluated for copper and other heavy metals by growing it in different types of Cu-mine soils and slags. Growth parameters such as shoot height and biomass weight (fresh and dry) were evaluated. Castor showed a high tolerance index (TI) in Cu-mine soils. The highest TI was calculated for the fresh mass of castor shoots in E soil with a percentage of 405.99. The translocation factor (TF) of all the metals except boron (B) and manganese (Mn) was less then 1, which reveals that these metals are stabilised in the root portion of the castor. Bioconcentration factor (BCF) value less then 1 for Cu indicates that castor is not a hyperaccumulator plant for copper. In addition to high concentrations of copper, other heavy metals such as arsenic (As), iron (Fe), and zinc (Zn) were observed in the roots than in shoots. Castor grown in slag accumulated Cu in the shoots, roots, and entire plant with the values of 25, 1184, and 1209 mg kg-1, respectively. Similarly, castor cultivated in A soil accumulated 18, 901, and 919 mg kg-1 of copper in shoots, roots, and entire plant, respectively. The calculated plant effective number (PENt) indicated the need for 253 castor plants to remove 1 g of Cu from E soil. The ability of castor to grow well in Cu-mine soils suggests that it can be used for the removal of Cu and other heavy metals. Additionally, the shoot portion could potentially be used for oil production since the phytoaccumulation levels of heavy metal concentration in the shoots were below the standard toxicity limits.This paper presents a comprehensive and critical comparison of four types of constructed wetlands (CWs) free water surface CW (FWSCW), vertical flow CW (VFCW), horizontal flow CW (HFCW), and hybrid CW (HCW) for the removal of 29 pharmaceuticals (PhCs) and 19 transformation products (TPs) using a global data compiled for 247 CWs reported in 63 peer-reviewed journal papers. Biodegradation (aerobic being more efficient than anaerobic) is the major removal mechanism for 16 out of 29 PhCs besides the influence of other processes (e.g., adsorption/sorption, plant uptake, and photodegradation). The HCW performed better followed by VFCW, HFCW, and FWSCW. The comparatively better removal in HCW might be due to the coexistence of aerobic and anaerobic conditions and longer hydraulic retention time considering more than one compartment enhances the removal of PhCs (e.g., diclofenac, acetaminophen, sulfamethoxazole, sulfapyridine, trimethoprim, and atenolol), which are removed under both conditions and adsorption/sorption processes. The augmentation in dissolved oxygen by the application of artificial aeration improved the removal of PhCs, which are degraded under aerobic conditions. Furthermore, the better performance of aerated CWs could be due to the establishment of various microenvironments with different physicochemical conditions (aerobic and anaerobic), which facilitated the contribution of both aerobic and anaerobic metabolic pathways in the removal of PhCs. The removal of some of the PhCs takes place by the formation of their TPs and the nature of these TPs (persistent or non-biodegradable/biodegradable) plays a major role in their removal process.One of the most important ecological processes is the formation of interspecific relationships in relation to spatial patterns among alpine cushion plants in extreme environmental habitats. However, such relationships remain poorly understood. Here, we examined the spatial patterns of alpine cushion plants along an altitudinal gradient of environmental severity and the interspecific relationship between two cushion species (Thylacospermum caespitosum and Androsace tangulashanensis) on the eastern Kunlun Mountain of China. Our results showed that the two species were highly aggregated within a distance of 2.5-5 m at the mid (S2) altitude, whereas they were randomly distributed at the low (S1) and high (S3) altitudes. A positive spatial interaction between the two species was observed over shorter distances at the mid (S2) altitude, and the spatial patterns were related to the size of individuals of the two species. Moreover, the impact of A. tangulashanensis on T. caespitosum (RIIT. caespitosum) was negative in all the study plots, and a positive impact of T. caespitosum on A. tangulashanensis (RIIA. tangulashanensis) was only observed at the mid (S2) altitude. Together, these results demonstrated that the spatial patterns of these two cushions varied with environmental severity, since the outcome of the interactions were different, to some extent, at the three altitudes. Plant size is the main factor affecting the spatial correlation and interspecific relationship between two cushions. Therefore, its potential influence should be considered when discussing interspecific relationships among cushions and their community construction at small scales in alpine ecosystems.Triclosan (TCS), an antimicrobial agent, has been a pollutant of increasing concern owing to its potential health risk on humans and aquatic animals. The present study seeks to test the hypothesis that TCS could alter the oxidative stress-related parameters in the brain and liver, as well as eliciting DNA damage in hepatocytes of adult zebrafish. Bcl-2 inhibitor On the basis of the 96 h LC50 (398.9 μg/L), adult zebrafish were separately exposed to 50, 100, and 150 μg/L TCS for 30 days. The brain and liver tissues from adult zebrafish were excised and assayed for a suite of antioxidant parameters and oxidative stress biomarkers including DNA damage in the liver. The induced effect by TCS on the activity of acetylcholinesterase (AChE) was also analyzed in the brain. Results showed a significant decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the brain and liver of adult zebrafish. Also, the contents of the glutathione system (GSH and GSSH), as well as the activity of the glutathione reductase (GR), assayed in the liver, were reduced while the contents of malondialdehyde (MDA) were elevated in the liver.
Read More: https://www.selleckchem.com/Bcl-2.html
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