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INTRODUCTION Statins were proposed to be neuroprotective; however, the effects are unknown in progressive supranuclear palsy (PSP), a pure tauopathy. METHODS Data of 284 PSP cases and 284 age-matched, sex-matched, and race-matched controls were obtained from the environmental and genetic PSP (ENGENE-PSP) study. Cases were evaluated with the PSP Rating Scale, Unified Parkinson's Disease Rating Scale, Mattis Dementia Rating Scale, and Neuropsychiatric Inventory. Statin associations with PSP risk, onset age, and disease features were analyzed. RESULTS Univariate models showed lower PSP risk for type 1 statin users (simvastatin, lovastatin, pravastatin). After adjusting for confounding variables, statin use and lower PSP risk association remained only at a trend level. For PSP cases, type 1 statins were associated with 1-year older onset age; type 2 statins (atorvastatin, rosuvastatin) were associated with the lower PSP Rating Scale and Unified Parkinson's Disease Rating Scale. CONCLUSION Statins may have inverse associations with PSP risk and motor impairment. Randomized prospective studies are required to confirm this effect. © 2020 International Parkinson and Movement Disorder Society. © 2020 International Parkinson and Movement Disorder Society.A 75-year-old postmenopausal lady presented with the chief complaints of bleeding per vagina for the last 2 months. On examination, the lady had pallor. Per vaginal examination revealed an ulceroproliferative growth at the posterior lip of the cervix measuring 3 cm x 3cm. The growth was brownish-black. There was no inguinal lymphadenopathy. There was no mass elsewhere in the body. This article is protected by copyright. All rights reserved.AIMS AND OBJECTIVE To investigate the effects on the quality of care of the Patient Report Informing Self-Management Support (PRISMS) form compared with usual care among patients with Chronic Obstructive Pulmonary Disease (COPD) consulting a COPD nurse in primary health care. BACKGROUND Patients with COPD experience symptoms affecting their everyday lives and there is a need for interventions in self-management support. The delivery of chronic care in an organized, structured, and planned manner can lead to more productive relationships between professionals and patients. DESIGN A multicentre randomised controlled trial with a post-test design, according to the CONSORT checklist, in one intervention group (n=94) and one control group (n=108). METHODS In addition to usual care, the intervention group (n=94) completed the PRISMS form to indicate areas where they wanted self-management support before the consultation with the COPD nurse. This form comprises 17 items that patients with COPD commonly experience as tool in improving person-centred care when delivering self-management support. This article is protected by copyright. All rights reserved.A simple and efficient method for the regioselective iodophosphoryloxylation of alkenes with P(O)-OH bonds has been established by using NIS (N-iodosuccinimide) as the iodination reagent under transition-metal-free conditions. The present protocol is compatible with different functional groups, and suitable for various alkenes and P(O)-OH compounds. A variety of functionalized β-iodo-1-ethyl phosphinic/phosphoric acid esters are obtained in good to excellent yields, which could be further transformed to diversified building blocks for the synthesis of bioactive compounds, pharmaceuticals and functional materials . © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.AIM This study aimed to develop a grounded theory of the patients' experiences with patient-controlled admission BACKGROUND Research indicates a potential for involving patients in mental health care, but there is a need to develop and investigate new approaches in health services. Patient-controlled admission is an option for patients with severe mental disorders to refer themselves for a brief hospital admission when needed and thus avoid the usual admission procedure DESIGN Classic grounded theory with generation of a theory based on the constant comparative method for data collection and analysis. METHODS Field observations and interviews with 26 mental health patients. The COREQ checklist was followed. RESULTS We found that patient-controlled admission induced safety by providing faster access to help and thus preventing further deterioration of symptoms. Being self-determined, achieving calmness, and receiving care with support and guidance from professionals during admission contributed to the sense ofThis article is protected by copyright. All rights reserved.AIMS AND OBJECTIVES To synthesize and review literature related to instruments that measure psychosocial aspects of fundamental care in acute hospital care settings. BACKGROUND Psychosocial aspects of care often receive less priority in terms of care provision in acute care environments. At the same time if these elements are overlooked there may be consequences. Despite the availability of many instruments designed to measure specific aspects of care these concepts are often not studied within the broader context of fundamentals of care, but rather coexist as isolated explorations of specific sub elements. find more DESIGN A scoping review was conducted, based on Arksey & O'Malley's (2005) methodological framework and following the PRISMA checklist. METHODS Using the five recommended steps -identifying the research question; identifying relevant studies; study selection; charting the data; summarizing and reporting the results - three databases were searched MEDLINE/Pubmed, CINHAL, and EMBASE in February 2019. RESULTSht. All rights reserved.We use 60-MHz benchtop nuclear magnetic resonance (NMR) to acquire 1 H spectra from argan oils of assured origin. We show that the low-field NMR spectrum of neat oil contains sufficient information to make estimates of compositional parameters and to inform on the presence of minor compounds. A screening method for quality and authenticity is presented based on nearest-neighbour outlier detection. A variety of oil types are used to challenge the method. In a survey of retail-purchased oils, several instances of fraud were found. © 2020 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.
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