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A case can be made that depression evolved to facilitate a deliberate cognitive style (rumination) in response to complex (often social) problems. What this further suggests is that those interventions that best facilitate the functions that those adaptations evolved to serve (such as rumination) are likely to be preferred over those like medications that simply anesthetize the distress. We consider the mechanisms that evolved to generate depression and the processes utilized in cognitive behavior therapy to facilitate those functions from an adaptationist evolutionary perspective.In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of this study was to examine whether the amount of benzodiazepine administered to treat withdrawal symptoms was associated with longitudinal changes in Glu, Glx, and GABA. The tNAA levels served as an internal quality reference; in agreement with the vast majority of previous reports, these levels were initially decreased and normalized during the course of abstinence in ADPs. Our results on Glu and Glx support hyperglutamatergic functioning during alcohol withdrawal, by showing higher ACC Glu and Glx levels on the first day of detoxification in ADPs. Withdrawal severity is reflected in cumulative benzodiazepine requirements throughout the withdrawal period. The importance of withdrawal severity for the study of GABA and Glu changes in early abstinence is emphasized by the benzodiazepine-dependent Glu, Glx, and GABA changes observed during the course of abstinence.Background This study assessed the hypothesis that violent behavior prior to admission prolongs psychiatric hospitalization and evaluated the likelihood of hospital discharge to a community care setting based on demographic and clinical factors, with an emphasis on violent behavior. Methods We retrospectively selected 362 patients who were involuntarily admitted to a psychiatric hospital in Japan from December 1, 2015 to November 30, 2017, stayed longer than planned, and underwent review by a multidisciplinary team. We assessed (a) education and marital status and history of substance abuse, (b) the presence/absence and type of violent behavior that led to hospital admission, and (c) the discharge criteria. We divided the subjects into groups according to whether they had demonstrated violent behavior prior to admission and compared demographic and clinical variables between the groups using bivariate analysis. We also analyzed data using the Cox proportional hazard model, defining discharge to the community as the outcome. Age, sex, and variables that were significant at a level of P less then 0.05 based on Cox univariate analysis were included in the multivariate models using the forced entry method. Results The Violent group included 94 patients (26%). There were no significant between-group differences in age, sex, educational background, marital history, career history, or the history of substance abuse. Muvalaplin cell line However, hospitalization was significantly longer in the Non-violent group. The Cox proportional multivariate hazard ratios revealed that violent behavior prior to admission resulted in a higher probability of hospital discharge. Conclusion Violent behavior prior to admission did not significantly contribute to prolonged hospitalization in patients who deviated from the treatment plan and had exceeded the planned hospitalization duration. Our findings recommend caution when using violence and impulsiveness observed during the acute stage to predict the difficulty of long-term treatment.A previous study reported that 3-min of high-intensity static stretching at an intensity of 120% of range of motion (ROM) did not change the muscle stiffness of the rectus femoris, because of the overly high stress of the stretching. The purpose of this study was to examine the effects of high-intensity static stretching of a shorter duration or lower intensity on the flexibility of the rectus femoris than that of the previous study. Two experiments were conducted (Experiment 1 and 2). In Experiment 1, eleven healthy men underwent static stretching at the intensity of 120% of ROM for two different durations (1 and 3 min). In Experiment 2, fifteen healthy men underwent 3-min of static stretching at the intensity of 110% of ROM. The shear elastic modulus of the quadriceps were measured. In Experiment 1, ROM increased in both interventions (p less then 0.01), but the shear elastic modulus of the rectus femoris was not changed. In Experiment 2, ROM significantly increased (p less then 0.01), and the shear elastic modulus of the rectus femoris significantly decreased (p less then 0.05). It was suggested that the stretching intensity (110%) is more important than stretching duration to decrease the muscle stiffness of the rectus femoris.This study aimed to analyze the status of sarcopenia, obesity, osteoporosis, and cardiometabolic disease according to the level of physical activity (PA) among elderly people in Korea. Among the data obtained from the National Health and Nutrition Survey (2008-2011), we analyzed the data of a total of 3,573 Korean elderly people over 65 years of age who were surveyed for dual X-ray absorptiometry (DXA) and PA. Higher levels of PA were associated with a lower prevalence of cardiometabolic disease (χ2 = 33.865, p less then 0.001), osteoporosis (χ2 = 94.198, p less then 0.001), sarcopenia, obesity, and sarcopenic obesity (χ2 = 71.828, p less then 0.001). Above moderate-active PA was associated with lower body weight (p less then 0.001), body fat mass (p less then 0.001), and percent body fat (p less then 0.001), and higher free-fat mass (p less then 0.001) and appendicular skeletal muscle mass (ASM) (p less then 0.001) than in low-active PA. In addition, when high-active is the risk factors of cae significantly decreased in high-active PA. Therefore, we verified a lower prevalence of sarcopenia, osteoporosis, obesity, and cardiac metabolic disease in Korean elderly with more active PA. This suggests that more active PA maybe reduce the prevalence of sarcopenia, osteoporosis, obesity, and cardiometabolic diseases in older adults.
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