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RESULTS Statistical analysis showed the DMFT scores as follows - 1.568 for city proper, 2.917 for surrounding villages. The caries-free children were 38.4% and 17.5% for group 1 and group 2, respectively. OHI is the highest predicting factor in a multifactorial regression analysis with over 19% predictive function. CONCLUSION There was statistically significant difference in caries prevalence and percentage of caries-free children between the city proper and the surrounding villages. Etiological factors have specific influence in the investigated age group. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.AIM The objective of this study was to carry out an in vivo investigation of patients wearing dentures relined with soft materials, assuming their positive and negative alterations in time. MATERIALS AND METHODS A direct survey method was used to gather data from 23 patients included in this study (11 male and 12 female patients). Twenty-seven dentures were made (12 partial and 15 total dentures) 9 of which in chairside procedures, 11 - in a laboratory, and 7 were made using the direct-indirect method. Patients were included in regular follow-ups at one month and six months, and at one, two, and three years after dentures delivery. The study started in 2014 and continued till 2017. RESULTS AND DISCUSSION All participants completed questionnaires which included questions related to changes in retention and stability of the relined dentures, changes in color and softness, in bond strength, and inflammation. CONCLUSION There were no significant differences in the behavior of the different groups of materials at six months. After six months we observed decline in the bond strength of the vinyl-polysiloxane (VPS) materials, as well as increased staining and hardness in the poly-methyl-methacrylate (PMMA). Liraglutide mouse This is an open access article distributed under the terms of the CC0 Public Domain Dedication.BACKGROUND Dental students are at high risk of developing adverse respiratory reactions as a result of their practical work during their dentistry degree program when they come into contact with multiple airborne irritants and allergens. AIM To estimate the prevalence of respiratory symptoms of exposure to substances in the workplace and associated risk factors in Bulgarian dental students. RESULTS The prevalence of self-reported respiratory symptoms related to the pre-clinical and clinical training courses of the dentistry program was 12.4%. According to logistic regression analysis, the most important risk factors for work-related respiratory symptoms were a personal history of allergic rhinoconjunctivitis (odds ratio (OR) 6.34, 95% confidence interval (CI) 3.14-12.78), atopic dermatitis (OR 2.81, 95%CI 1.26-6.26), and exposure to chemicals from dental environment for more than 6 hours a day (OR 3.60, 95%CI 1.21-10.70). CONCLUSION The results of this study suggest that work-related respiratory symptoms are frequent among dental students and indicate the need for efforts to establish effective primary preventive programs for occupational respiratory disorders at national level. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND Broncho-pleural fistula (BPF) can occur after pulmonary resections as a complication with high morbidity and mortality rates. AIM In the present study, we analyzed the relation between the possible risk factors and the two major bronchial closure techniques for BPF after lung resections, and the management methods of BPF. MATERIALS AND METHODS A total of 26 cases detected and managed with BPF diagnosis in our clinic between September 2005 and September 2017 were evaluated retrospectively. The cases were divided into two groups Group 1 (n=14); bronchial closure performed manually and Group 2 (n=12) bronchial closure with stapler. We analyzed cases for age, gender, body mass index, pulmonary function tests, time to fistula, total protein/albumin level, length of hospital stay, bronchial stump distance, presence of bronchial stump coverage, and the mean survivals. RESULTS Twenty-three of the cases were males (88.5%) with a mean age of 60.03±8.7 years (range 38-73). While BPF was detected in twenty-thre (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.INTRODUCTION 2-AAF and DEN are well-known liver toxicants commonly used to stimulate tumors in laboratory animals. AIM The aim of this study was to investigate the effect of octreotide on DEN-induced and 2-AAF-supplemented hepatocarcinogenesis in Wistar albino rats. MATERIALS AND METHODS In this study, 64 Wistar albino rats were divided into 8 groups. DEN (175 mg/kg) initiated and 2-AAF (20 mg/kg) promoted liver carcinogenesis in rats. The tumor growth inhibitor octreotide (300 μg/kg) was used. Rats were sacrificed at the end of experiment and their liver tissues were taken for the study. SOD, GSH-Px, CAT activities, NO and MDA levels were measured spectrophotometrically. Also, Hsp70 and 8-OHdG was measured by the ELISA method. RESULTS In group 7, MDA, 8-OHdG, and Hsp70 levels were significantly increased. In addition, SOD, GSH-Px activity was significantly reduced in this group. MDA, 8-OHdG and Hsp70 levels were significantly reduced in Group 8, which received octreotide for treatment. CONCLUSION DEN and 2-AAF cause very serious liver damage. Octreotide protects the liver from carcinogenesis, increases the activity of cellular antioxidant enzymes and helps reduce DNA damage. Therefore, octreotide may be an inhibitor in tumor cells and may reduce oxidative stress. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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