Notes

Commotio Cordis Due to Brother or sister Competition.
Pexidartinib is the first approved medication in the USA for people with tenosynovial giant cell tumor (TGCT). The drug was approved based on the ENLIVEN study, which looked at pexidartinib (brand name, Turalio™), a medication taken by mouth (orally) for people with TGCT (also known as giant cell tumor of the tendon sheath [GCTTS] and pigmented villonodular synovitis [PVNS]) who are not able to have surgery because of the location and/or the size of the tumor. The study showed that pexidartinib is effective in treating people with TGCT because it shrunk the size of their tumors and improved their symptoms and their ability to function. Sepantronium In general, people treated with pexidartinib had side effects that were mostly mild that went away after treatment with pexidartinib was stopped. The most common side effects were hair color changes and tiredness (fatigue). Pexidartinib was also associated with liver problems (or hepatotoxicity), which started within the first 2 months of treatment. Due to the risk of liver problems, which may be severe and potentially life threatening, the researchers closely monitored participants' blood liver function tests before, during, and after participants in the study took pexidartinib. To read the full Plain Language Summary of this article, click on the View Article button above and download the PDF. Clinical Trial Registration NCT02371369 (ClinicalTrials.gov).
No current technology exists to ensure the dose of insulin administered in hospitals matches the physician order.

Assess the feasibility of using computer vision to identify insulin syringe preparation errors.

Twenty-two nurses prepared 50 insulin doses (n=1100) each. A computer vision device (CVD) measured the volume drawn up and identified air present. Syringes identified as inaccurate by the CVD were confirmed by two observers, and a random sample of 100 syringes identified as accurate was validated by two independent observers.

Ten syringes (1.0%) had the wrong volume prepared, and 68 syringes (6.5%) contained air sufficient to meet the definition of inaccuracy. All errors were confirmed by two independent observers.

CVDs could reduce insulin administration errors in hospitalized patients.
CVDs could reduce insulin administration errors in hospitalized patients.Background and Objectives This research examined whether life meaning promotes resilience to stressor-related psychological distress and repetitive negative thinking. Design and Methods Three studies (total N = 273) used cross-sectional (Study 1) and prospective (Studies 2 and 3) designs to assess the relation between life meaning and response to various stressors. Results Results showed that in Study 1, greater life meaning was inversely related with repetitive negative thinking and psychological distress. Further, a mediation analysis showed an indirect effect for the life meaning-repetitive negative thinking relation through psychological distress. In Study 2, baseline life meaning predicted less repetitive negative thinking about a subsequent city-wide flood. In Study 3, baseline life meaning was inversely related to distress and repetitive negative thinking after writing about an aversive memory. A mediation analysis showed an indirect effect for the life meaning-repetitive negative thinking relation through distress. Conclusions In all studies, life meaning predicted outcomes when controlling for other positive well-being variables. Overall, the findings suggest that individuals with greater trait life meaning experience less stressor-related distress and repetitive negative thinking and that the life meaning-repetitive negative thinking relation may be mediated by distress.
To assess long-term anatomic and functional outcomes of early lens-sparing vitrectomy (LSV) for stage 4A retinopathy of prematurity (ROP) in infants with aggressive-posterior ROP (AP-ROP) which progressed to retinal detachment despite laser treatment.

Chart review of infants who underwent early 25-gage LSV for stage 4A ROP. Outcomes were anatomic success, mean visual acuity (VA), development of postoperative complications, and refractive changes. Follow-up examinations were performed at 1, 3, 6, 12, and then every 6 months.

Ten eyes of seven preterm infants who underwent LSV were included. Mean follow-up was 36 ± 13.4 months and mean postmenstrual age (PMA) at last follow-up was 37 ± 13.7 months. Mean gestational age (GA) and weight at birth was 26 ± 1.4 weeks and 639 ± 180 g. Two eyes had vitreous hemorrhage 4 and 14 days after surgery, respectively. At last follow-up anatomic success was 100%, mean VA was 20/80 and eight eyes (80%) had high myopic refractive correction (mean spherical equivalent -11.25 D).

Early LSV for stage 4A ROP with AP-ROP and progression to retinal detachment is efficacious in terms of anatomic and functional outcomes. Anatomic success is associated with visual improvement despite possible myopic refraction changes during follow-up.
Early LSV for stage 4A ROP with AP-ROP and progression to retinal detachment is efficacious in terms of anatomic and functional outcomes. Anatomic success is associated with visual improvement despite possible myopic refraction changes during follow-up.
The aim of this study was to evaluate the efficacy and safety of injection of allogeneic growth factors in patients with plantar fasciitis.

This study included 150 patients who were randomly divided into 2 equal groups; the patients were locally injected with allogeneic growth factors (GFs) (treatment group) or with saline 0.9% (control group). The patients were assessed using visual analog scale (VAS) and Foot Function Index-Revised short form (FFI-Rs) scores preinjection and 1, 3, 6, and 12 months postinjection. The patients were questioned about their satisfaction. Any adverse effects were recorded.

At baseline, there was no significant difference between both groups regarding the mean VAS and FFI-Rs scores. At 3-month follow-up, the reduction in mean VAS score was 87% in the treatment group and 55% in the control group (
< .001), and the reduction in mean FFI-Rs score was 62% in the treatment group and 40% in the control group (
< .001). Treatment group and study visit were significant factors affecting both VAS and FFI-Rs scores.
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