Notes

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Contextual conditions are classified into organizational-structural, political-legal and ethical aspects. The following were considered to be most relevant lack of communication between the actors, uncertainties among staff, absent living wills and increasing workload in nursing. Conclusions Emergencies in nursing homes turn out to be complex emergency scenarios. Contextual conditions are important for dealing with emergency scenarios in nursing homes. Recommended actions should be based on the perspective of involved practitioners on emergencies and take greater account of the contextual conditions.
This study systematically evaluated the safety and efficacy of dexmedetomidine for procedural sedation and postoperative behaviors in a pediatric population as well as whether the results met the information required to draw conclusions.

To evaluate the safety and efficacy evaluation of dexmedetomidine for procedural sedation and postoperative behaviors in a pediatric population.

PubMed, Cochrane library, Web of Science and Ovid MEDLINE were searched to obtain randomized controlled trials (RCTs) comparing dexmedetomidine with control medicine and comparing different doses of dexmedetomidine.

There were a total of 16 RCTs for a total of 3240 patients. Dexmedetomidine slowed down the heart rate (HR; mean difference -13.27; 95% CI -16.41 to 10.14;
< 0.001) and reduced postoperative delirium (risk ratio [RR] 0.31; 95% CI 0.20-0.50;
< 0.001), the number of pain patients (RR 0.48; 95% CI 0.30-0.75;
= 0.002), and desaturation (RR 0.34; 95% CI 0.13-0.89;
= 0.03) compared with the control gron be considered as a related medicine for safety in pediatric surgery.The catalytic construction of a monocyclic medium-sized N,O-heterocyclic ring represents a formidable challenge in organic synthesis. Herein we report the synergistic palladium(0)/rhodium(II) dual catalytic cycloaddition of vinylpropylene carbonates with N-sulfonyl-1,2,3-triazoles to afford monocyclic nine-membered N,O-heterocycles. The catalytically generated 1,6-dipole-equivalent zwitterionic π-allyl palladium(II) complex and the 1,3-dipole-equivalent α-imino rhodium(II) carbenoid intermediate react with each other in a formal [6 + 3] dipolar cycloaddition to furnish nine-membered oxazonines, which can be transformed into cis-fused [4.3.0] bicyclic compounds via a transannular Alder-ene rearrangement. The tandem one-pot cycloaddition/Alder-ene rearrangement sequence is also possible.Photonic pigment particles prepared via self-assembly have been suffering from their poor mechanical performances; i.e., they can easily be damaged and lose structural color under a compression force. This greatly limits their uses as mechanochromic pigments. Here, a nanoscale concentric lamellar structure of alternating glassy-rubbery microdomains is successfully created within photonic microparticles through a confined self-assembly and photo-cross-linking strategy. The glassy domain is composed of polystyrene, and cross-linked bottlebrush polydimethylsiloxane served as the supersoft elastic domain. The obtained photonic structure not only shows large deformation and visible color changes under a loaded compression force but also rapidly recovers to its original state in less than 1 s (∼0.16 s) upon unloading. Continuously loading-unloading micro compression test indicates that no obvious damage can be identified after 250 cycles, indicating the high durability of the pigments against deformation. These pigments with different reflected colors are simply obtained using bottlebrush block copolymer formulations with tunable weight percentages of polymer additives. The mechanical robust photonic pigments may be useful in many important applications.Air-flow sensing is essential in broad applications of weather forecasting, ocean monitoring, gas leakage alarming, and health monitoring. However, in severe environments where electrical power supply and cable connection are not available, the sensing of air flow in a self-powered way is a challenging issue. In this work, we reported a tribo-induced smart reflector to achieve the self-powered wireless sensing of the air flow by combining an aerodynamics-driven triboelectric nanogenerator (TENG) and a silver-coated polymer network liquid crystal. Upon being driven by the air flow, the developed reflector performed specular and diffused reflectance without and with charging by the TENG, respectively, enabling wireless sensing through mechanical-electrical-optical signal conversion. In the developed sensing paradigm, the sensing module can be fully self-powered without the need of signal pre-amplification, which is electrically separated from the light source and detection modules without cable connections. MLN8237 The applications of self-powered wireless wind speed sensing and breath monitoring were performed to demonstrate the effectiveness of the developed paradigm toward self-powered wireless sensing nodes in the internet of things.The quantum mechanics/molecular mechanics (QM/MM) approach is an essential and well-established tool in computational chemistry that has been widely applied in a myriad of biomolecular problems in the literature. In this publication, we report the integration of the QUantum Interaction Computational Kernel (QUICK) program as an engine to perform electronic structure calculations in QM/MM simulations with AMBER. This integration is available through either a file-based interface (FBI) or an application programming interface (API). Since QUICK is an open-source GPU-accelerated code with multi-GPU parallelization, users can take advantage of "free of charge" GPU-acceleration in their QM/MM simulations. In this work, we discuss implementation details and give usage examples. We also investigate energy conservation in typical QM/MM simulations performed at the microcanonical ensemble. Finally, benchmark results for two representative systems in bulk water, the N-methylacetamide (NMA) molecule and the photoactive yellow protein (PYP), show the performance of QM/MM simulations with QUICK and AMBER using a varying number of CPU cores and GPUs. Our results highlight the acceleration obtained from a single or multiple GPUs; we observed speedups of up to 53× between a single GPU vs a single CPU core and of up to 2.6× when comparing four GPUs to a single GPU. Results also reveal speedups of up to 3.5× when the API is used instead of FBI.
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