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Pre-natal diagnosing Baraitser -- Wintertime symptoms using exome sequencing: Medical record and overview of books.
[email protected] Melioidosis, infection caused by the bacterium Burkholderia pseudomallei, is a common cause of sepsis with high associated mortality in Southeast Asia. Identification of patients at high-likelihood of clinical deterioration is important for guiding decisions about resource allocation and management. We sought to develop a biomarker-based model for 28-day mortality prediction in melioidosis. METHODS In a derivation set (N=113) of prospectively enrolled, hospitalized Thai patients with melioidosis, we measured concentrations of interferon-γ, interleukin-1β, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α, granulocyte-colony stimulating factor and interleukin-17A. We used least absolute shrinkage and selection operator (LASSO) regression to identify a subset of predictive biomarkers and performed logistic regression and receiver operating characteristic curve analysis to evaluate biomarker-based prediction of 28-day mortality compared to clinical variables. We repeated select anay of America.BACKGROUND Cross-sectional studies have shown that noise annoyance is strongly associated with mental distress, however, its long-term effects on mental health is unknown. We therefore investigated whether noise annoyance predicts depression, anxiety and sleep disturbance in a large, representative sample 5 years later. METHODS We investigated longitudinal data of N = 11 905 participants of the Gutenberg Health Study, a population-based, prospective, single-centre cohort study in mid-Germany (age at baseline 35-74 years). Noise annoyance was assessed at baseline and 5-year follow-up (sources road traffic, aircraft, railways, industrial, neighbourhood indoor and outdoor noise; and day vs. nighttime). Depression, anxiety and sleep disturbance were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-2. Participants suffering from depression, anxiety or sleep disturbance at baseline were excluded from the respective multivariate analyses of new onset at follow-up. RESULTS General noerved.STUDY OBJECTIVES Slow oscillations (SO) during slow-wave sleep foster the consolidation of declarative memory. Children with ADHD display deficits in the sleep-associated consolidation of declarative memory, possibly due to an altered function of SO. The present study aimed at enhancing SO activity using closed-looped acoustic stimulation during slow wave sleep in children with ADHD. METHODS Twenty nine male children (14 with ADHD; aged 8-12 yrs.) participated in a double-blind, placebo-controlled study trial. Children spent two experimental nights in a sleep lab, one stimulation night and one sham night. A declarative learning task (word-pair learning) with a reward condition was used as primary outcome. Secondary outcome variables were a procedural memory (serial reaction time) and working memory (n-back) task. Encoding of declarative and procedural memory took place in the evening before sleep. After sleep, the retrieval took place followed by the n-back task. RESULTS The stimulation successfully induced SO activity during sleep in children with and without ADHD. After stimulation, only healthy children performed better on high-rewarded memory items (primary outcome). In contrast, there were indications that only children with ADHD benefitted from the stimulation with respect to procedural as well as working memory performance (secondary outcome). CONCLUSIONS We were able to show that the acoustic closed-loop stimulation can be applied to enhance SO activity in children with and without ADHD. Our data indicate that SO activity during sleep interacts with subsequent memory performance (primary outcome rewarded declarative memory, secondary outcome procedural and working memory) in children with and without ADHD. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. TAK243 All rights reserved. For permissions, please e-mail [email protected] ketosis (or ketone body ingestion) can ameliorate several changes associated with neuroprogressive disorders including schizophrenia, bipolar disorder and major depressive disorder. Thus, the effects of glucose hypometabolism can be bypassed through the entry of beta-hydroxybutyrate, providing an alternative source of energy to glucose. The weight of evidence suggests that induced ketosis reduces levels of oxidative stress, mitochondrial dysfunction and inflammation - core features of the above disorders. There is also data to suggest that induced ketosis may be able to target other molecules and signalling pathways whose levels and or activity are also known to be abnormal in at least some patients suffering from these illnesses such as peroxisome proliferator-activated receptors (PPARs), increased activity of the Kelch-like ECH-associated protein (KEAP)/nuclear factor erythroid 2-related factor 2 (NRF-2),Sirtuin-1(SIRT-1) nuclear factor (NF)-κB p65 and NAD This review explains the mechanisms by which induced ketosis might reduce mitochondrial dysfunction, inflammation and oxidative stress in neuropsychiatric disorders and ameliorate abnormal levels of molecules and signalling pathways which also appear to contribute to the pathophysiology of these illnesses. This review also examines safety data relating to induced ketosis over the long term and discusses the design of future studies. © The Author(s) 2020. Published by Oxford University Press on behalf of CINP.OBJECTIVES The aim of this study was to investigate the impact of various brain perfusion techniques and nadir temperature cooling strategies on outcomes after aortic arch repair in a contemporary, multicentre cohort. METHODS A total of 2520 patients underwent aortic arch repair with hypothermic circulatory arrest (HCA) between 2002 and 2018 in 11 centres of the Canadian Thoracic Aortic Collaborative. Primary outcomes included mortality; stroke; a composite of mortality or stroke; and a Society of Thoracic Surgeons-defined composite (STS-COMP) end point for mortality or major morbidity including stroke, reoperation, renal failure, prolonged ventilation and deep sternal wound infection. Multivariable logistic regression and propensity score matching were performed for cerebral perfusion and nadir temperature practices. RESULTS Antegrade cerebral perfusion was found on multivariable analysis to be protective against mortality [odds ratio (OR) 0.64, 95% confidence interval (CI) 0.48-0.86; P = 0.005], stroke (OR 0.
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