Notes

Discerning and self-validating breath-level diagnosis associated with hydrogen sulfide inside humid atmosphere by simply gold nanoparticle-functionalized nanotube arrays.
The KCNA1 gene encodes the α subunit of the voltage-gated Kv1.1 potassium channel that critically regulates neuronal excitability in the central and peripheral nervous systems. Mutations in KCNA1 have been classically associated with episodic ataxia type 1 (EA1), a movement disorder triggered by physical and emotional stress. see more Additional features variably reported in recent years include epilepsy, myokymia, migraine, paroxysmal dyskinesia, hyperthermia, hypomagnesemia, and cataplexy. Interestingly, a few individuals with neuromyotonia, either isolated or associated with skeletal deformities, have been reported carrying variants in the S2-S3 transmembrane segments of Kv1.1 channels in the absence of any other symptoms. Here, we have identified by whole-exome sequencing a novel de novo variant, T268K, in KCNA1 in a boy displaying recurrent episodes of neuromyotonia, muscle hypertrophy, and skeletal deformities. Through functional analysis in heterologous cells and structural modeling, we show that the mutation, located at the extracellular end of the S3 helix, causes deleterious effects, disrupting Kv1.1 function by altering the voltage dependence of activation and kinetics of deactivation, likely due to abnormal interactions with the voltage sensor in the S4 segment. Our study supports previous evidence suggesting that specific residues within the S2 and S3 segments of Kv1.1 result in a distinctive phenotype with predominant musculoskeletal presentation.
the purpose of this analysis was to analyze the outcomes of multimodal treatment that are related to Lauren histotypes in gastro-esophageal cancer (GEC).

patients with GEC between 1986 and 2013 were analyzed. Uni- and multivariate regression analysis were performed to identify predictors for overall survival. Lauren histotype stratified overall survival (OS)-rates were analyzed by the Kaplan-Meier method. Further, propensity score matching (PSM) was performed to balance for confounders.

1290 patients were analyzed. After PSM, the median survival was 32 months for patients undergoing primary surgery (PS) and 43 months for patients undergoing neoadjuvant chemotherapy (nCTx) ahead of surgery. For intestinal types, median survival time was 34 months (PS) vs. 52 months (nCTx+surgery)
= 0.07, 36 months (PS) vs. (31) months (nCTx+surgery) in diffuse types (
= 0.44) and 31 months (PS) vs. 62 months (nCTx+surgery) for mixed types (
= 0.28). Five-/Ten-year survival rates for intestinal, diffuse, and mixed types were 44/29%, 36/17%, and 43/33%, respectively. After PSM, Kaplan-Meier showed a survival benefit for patients undergoing nCTx+surgery in intestinal and mixed types.

the Lauren histotype might be predictive for survival outcome in GEC-patients after neoadjuvant/perioperative chemotherapy.
the Lauren histotype might be predictive for survival outcome in GEC-patients after neoadjuvant/perioperative chemotherapy.The COVID-19 pandemic that has hit the world in the year 2020 has put a strain on our ability to cope with events and revolutionized our daily habits. On 9 March, Italy was forced to lockdown to prevent the spread of the infection, with measures including the mandatory closure of schools and nonessential activities, travel restrictions, and the obligation to spend entire weeks in the same physical space. The aim of this study was to assess the impact of the COVID-19 pandemic and lockdown measures on quality of life (QoL) in a large Italian sample, in order to investigate possible differences in QoL levels related to both demographic and pandemic-specific variables. A total of 2251 Italian adults (1665 women, mainly young and middle adults) were recruited via a snowball sampling strategy. Participants were requested to answer to an online survey, which included demographic and COVID-related information items, and the World Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF). The results showed statistically significant differences in QoL depending on a number of variables, including sex, area of residence in Italy, and being diagnosed with a medical/psychiatric condition. To our knowledge, this is the first study to assess QoL during COVID-19 pandemic in Italy, therefore the present findings can offer guidelines regarding which social groups are more vulnerable of a decline in QoL and would benefit of psychological interventions.One year has passed with the COVID-19 pandemic and its impact is still evident everywhere on the globe and in all fields and domains [...].The technical maintenance of old tenement houses traditionally constructed is an ongoing problem, and will continue to be so in the coming years. The subject of the article includes old residential buildings from the turn of the XIX and XX centuries, which are a part of Wroclaw's downtown district. They can be understood as an essential link in the process of shaping the cultural and social microenvironment of man. The ability of them to meet the multiple expectations of residents depends on the natural aging of tenement houses' materials, the methods of their maintenance and use, and the influence of the many factors that cause their accelerated wear. The assumed durability is the main reference parameter of the changing age of the inspected tenement houses. The course of the theoretical and observed degree of the technical wear of these buildings was compared with their durability. For the age of these buildings, the technical wear should reach 100%. It was observed that in the first period of use of tenement houses, the phenomenon of "infradurability" occurs, and after exceeding a certain age-depending on the maintenance conditions of the building-the phenomenon of "overdurability" of the building occurs. It was shown that the durability of important elements of old buildings, as a parameter that was defined "a posteriori", ranges from 153 to 177 years, and is greater than the corresponding literature values indicated "a priori". The probability of reaching such an age of an element, in which the observed values of technical wear exceed the theoretical values, is much higher than the probability of an opposite event. A comparative analysis of the distribution functions of these probabilities indicates that the probabilities of theoretical wear values are higher than those observed in the case of the assumed literature durability of elements. There is also an inverse relationship for durability that corresponds to the age of the oldest examined elements of tenement houses.
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