Notes

Dysregulation involving ECRG4 is assigned to cancerous qualities and also prognostic value throughout individual gastric cancer malignancy.
05) and has more power to detect differences than alternative approaches. We then examine the necessary sample sizes for detecting invariant network structures with Bayesian hypothesis testing, in addition to how this is influenced by the choice of prior distribution. The methods are applied to posttraumatic stress disorder symptoms that were measured in 4 groups. We end by summarizing our major contribution, that is proposing 2 novel methods for comparing Gaussian graphical models (GGMs), which extends beyond the social-behavioral sciences. The methods have been implemented in the R package BGGM. (PsycINFO Database Record (c) 2020 APA, all rights reserved).Research indicates that lesbian, gay, and bisexual (LGB) youth are at increased risk for heavy drinking relative to their heterosexual peers. One possible contributing factor is that religiosity fails to provide the significant protection for LGB youth that it provides in general population samples. Although prior studies provide some support for this hypothesis, there is little research on the reasons that religiosity may fail to protect against heavy drinking among LGB youth. The current study addressed this question by examining relations among religiosity, age of self-identification as LGB, and alcohol use in a sample of 162 young adults self-identified as lesbian, gay, bisexual, or questioning. Age of self-identification was conceptualized as an indicator of stress or internal conflict between religious beliefs and self-identification. We hypothesized that higher levels of religiosity would be associated with a later age of identification as LGB, which, in turn, would contribute to heavier drinking. Path analyses conducted in Mplus provided support for this hypothesis, with higher levels of religiosity indirectly contributing to increased alcohol use through later age of self-identification. check details Whereas additional studies directly assessing stress associated with the self-identification process are needed, the results of this study suggest that religiosity may serve as a risk, rather than protective, factor among LGB youth. The development of religious support groups specifically for LGB youth may help these individuals reconcile their religious beliefs with their emerging sexual identities, thereby allowing them to derive some of the same benefits that heterosexual youth derive from religious beliefs and practices. (PsycINFO Database Record (c) 2020 APA, all rights reserved).The valine⁶⁶methionine (Val⁶⁶Met) polymorphism (rs6265) of the brain-derived neurotrophic factor (BDNF) gene has been shown to influence autonomic arousal pathways, which in turn predict elevated syndromal anxiety in healthy humans. We examined whether the BDNF variant is associated with an increased risk of generalized anxiety disorder (GAD), one of the most prevalent anxiety disorders, through altering parasympathetic stress/relaxation reactivity. A total of 2,250 Han Chinese adults (750 GAD patients and 1,500 healthy controls) were included in the genotyping. High-frequency heart rate variability, an index of vagal (parasympathetic) activity, was measured during the supine-standing-supine test (5 min in each position); vagal withdrawal and vagal activation were calculated as baseline supine minus standing and recovery supine minus standing, respectively. Analysis of healthy participants indicated that Val/Val homozygotes displayed significantly blunted vagal withdrawal and vagal activation compared with Met allele carriers. After analyzing the entire sample, these effects remained significant. Furthermore, both attenuated vagal response patterns were found to be significantly associated with a higher incidence of GAD. Lastly, the path analysis identified a significant indirect effect of BDNF on the risk of GAD via diminishing vagal response to either orthostatic stress or supine relaxation. Even when further testing the subsample comprising only comorbidity- and medication-free GAD patients and healthy controls to minimize the confounding bias, the results still remained. Our findings demonstrate that individuals carrying the BDNF Val/Val genotype, compared to Met-carriers, may be at higher risk of GAD due to blunted vagal reactivity in response to both stress and relaxation. (PsycINFO Database Record (c) 2020 APA, all rights reserved).OBJECTIVE Currently there is no universally agreed upon language for those seeking psychiatric treatment, and labels commonly include patient, client, consumer, and service user. Although there is some research regarding preferences for label (Dickens & Picchioni, 2012), little is known about how people perceive an individual differently based on the label used. The current study examined whether specific labels were associated with more stigmatizing attitudes. METHOD Participants recruited through MTurk (N = 526) were randomized to read a vignette of a man named Harry, described as a patient, client, consumer, or service user with mental illness. After correctly recalling the label from the vignette, participants were assessed for stigmatizing attitudes toward Harry. RESULTS ANOVAs indicated a no main effects of label on stigmatizing attitudes. A number of variables (e.g., overall stigma, dangerousness, segregation, and distance) revealed a significant interaction between label and prior mental health treatment For those who have sought prior mental health treatment, the term client may be more stigmatizing than other labels. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE The current study did not find general differences in stigmatizing attitudes associated with mental health treatment label. Although preliminary, these findings suggest treatment labels may not significantly impact stigmatizing attitudes. (PsycINFO Database Record (c) 2020 APA, all rights reserved).Described herein is a visible-light mediated intermolecular radical cyclization approach to access heterocycles. Heteroatom radicals, such as silicon and phosphorus atom radicals, were generated via direct hydrogen atom abstraction by the photoexcited catalyst species with hydro-silanes and phosphine oxides. The radical addition/cyclization/HAT (hydrogen atom transfer) reaction sequences of 1,6-enynes and 1,6-dienes were highly efficient delivering the desired heterocycles in good yields.
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