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A new vector system for fast-forward reports in the HOPZ-ACTIVATED RESISTANCE1 (ZAR1) resistosome from the design seed Nicotiana benthamiana.
Direct-acting antivirals (DAA) have revolutionized the treatment of chronic hepatitis C virus (HCV) infection.

To evaluate the clinical effectiveness of DAA in a safety-net population.

Retrospective cohort study including patients who received at least one dose of DAA for chronic HCV infection. Primary outcome was sustained virologic response (SVR) defined as undetectable viral load at least 12 weeks after treatment termination.

Notable patient (n=174) characteristics included 58% racial/ethnic minority group members, 34% Medicaid or uninsured, and 51% cirrhosis. Overall, SVR was 87.4%, including 15 patients who were lost to follow-up and deemed treatment failures. Multivariate analysis significantly associated completion of therapy on time (OR 4.55, p=.009) and the presence of insurance (OR 7.25, p=0.008) with SVR.

A favorable rate of SVR can be obtained in a safety-net population. The majority of treatment failure was due to patients being lost to follow-up.
A favorable rate of SVR can be obtained in a safety-net population. The majority of treatment failure was due to patients being lost to follow-up.There is a large body of literature on the role of social support systems in the management of chronic conditions in the West, with limited research on the sub-Saharan African and Ghanaian context. In the past, the organization and delivery of formal health services in Ghana were geared towards the treatment of infectious diseases rather than non-communicable diseases (NCDs). We conducted qualitative interviews with a sample of 33 NCD patients purposefully selected from two teaching hospitals in Ghana. The information they provided indicated that the most common types of support received were instrumental and emotional. While a majority of stroke patients experienced activity limitations related to bathing and cooking, they received the emotional support necessary to maintain their psychological well-being. Overall, we found social connections and relationships were an important strategy in the promotion of the physical and mental well-being of these NCD patients.
The paper investigates the disparities in infant and child mortality in Nigeria over the last two decades. The major contribution of this study is to document the disparities in infant and child mortality in Nigeria at the state level.

The paper employs both descriptive statistics, multivariate logistics regression, and multilevel logistics regression on data from IPUMS-Demographic and Health Surveys (IPUMS-DHS), 1990, 1999, 2003, 2008 and 2013 Version 5 datasets. The paper uses a multilevel logistic regression analysis on 216,049 observations nested within 1,766 clusters or neighborhoods in the 36 states and FCT, Abuja, Nigeria.

The paper finds that disparity in infant and child mortality is correlated to disparity in wealth, mother's educational attainment, and access to health care in Nigeria. Additionally, the study finds wide disparities in both infant and child mortality among the 36 states and FCT, Abuja, Nigeria. Conclusion and policy implication. ANA-12 supplier The paper finds evidence of clustering effect at both community and individual levels suggesting little difference in infant and child mortality within clusters. This is very significant when we connect the instability in certain states of Nigeria to the health of children in those states.
The paper finds that disparity in infant and child mortality is correlated to disparity in wealth, mother's educational attainment, and access to health care in Nigeria. Additionally, the study finds wide disparities in both infant and child mortality among the 36 states and FCT, Abuja, Nigeria. Conclusion and policy implication. The paper finds evidence of clustering effect at both community and individual levels suggesting little difference in infant and child mortality within clusters. This is very significant when we connect the instability in certain states of Nigeria to the health of children in those states.
Late diagnosis of breast cancer is associated with lower survival. This study determines the factors associated with late-stage breast cancer diagnosis in an urban safety-net hospital (SNH) with excess late-stage disease.

Single-institution retrospective study of all early-stage vs. late-stage breast cancer cases diagnosed or treated at the primary SNH in the Kansas City, Missouri area between January 2011-July 2018. Multiple logistic regression was performed to determine the variables that contributed most to late stage at diagnosis.

The most significant factor associated with late-stage diagnosis was lack of screening mammogram within two years of diagnosis (p<.0001, OR 7.5, CI = 3.6, 15.3). Patients referred from within the SNH compared with those presenting from community health centers were significantly less likely to present with late-stage disease (p=.04, OR 0.50, CI = 0.25, 0.98).

Screening mammography ought to be actively promoted in SNH settings with excess late-stage diagnosis.
Screening mammography ought to be actively promoted in SNH settings with excess late-stage diagnosis.Community paramedicine (CP) model of care integrates existing emergency medical service (EMS) resources with primary care, public health, social services and community engagement. However, published studies about CP programs in the U.S. are sparse. To understand how paramedics perceive CP programs and patients in the program, we surveyed and interviewed 16 community paramedics (10 men and 6 women) who are currently delivering health care within a CP program. Our analyses highlighted that community paramedics (1) defined CP patients in sympathetic terms; (2) reported patient and systemic factors contributing to ED overuse; and (3) expressed their frustrations and commendations for CP programs. Several suggestions were identified to improve CP program (all modifiable elements). Further, the frustrations expressed by paramedics highlight the barriers to health care access for underserved communities. We discuss the implications of this research for practice and recommend future qualitative studies on longer operating CP programs.
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