Notes

DRG bunch simply by machine learning: coming from expert-oriented to be able to data-based technique.
In the present study, a fast multiresidue method determining three novel fungicides fenpicoxamid, isofetamid, and mandestrobin in cereals was developed and validated for the first time using ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Samples were extracted by QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) methodology, and cleaned up using the disposable pipette extraction (DPX) tips containing primary secondary amine (PSA) and silica gel modified with zirconium oxide (Z-Sep) in less than 1 min. Linearity (r > 0.99) of three fungicides in the calibration range of 0.001-0.1 µg mL-1 was satisfactory. Mean recoveries (n = 15) from all matrices were between 84.8% and 100.3% as the corresponding intra-day and inter-day relative standard deviations (RSDs) were less than 10.6%. Limits of quantitation (LOQs) of all analytes in different matrices were defined at 0.01 mg kg-1. The results indicate this method can serve as a sensitive and rapid approach to monitoring contents of fenpicoxamid, isofetamid, and mandestrobin in cereals. Micro gas chromatography (µGC) is a technique developed for rapid, in situ analysis of volatile organic compounds (VOCs) for environmental protection, industrial monitoring, and toxicology. While reduced µGC size and power requirements allow for increased portability, the low moisture and oxygen resilience of current microcolumn technology result in increased peak broadening and tailing for humid samples, which necessitates the use of bulky helium or nitrogen carrier gas cartridges. Developing a microcolumn to address these deficiencies is desirable to improve µGC field performance and further reduce µGC system size. This paper reports the development and characterization of a microfabricated phosphonium ionic liquid (µIL) column and demonstrates separation of both polar and nonpolar compounds using this column via analyses of alcohols, chloroalkanes, aromatics, aldehydes, fatty acid methyl esters, and alkanes. The µIL column achieved operation at temperatures up to 345 °C for fatty acid methyl ester and alkane separation. Notably, all separations in this study used dry air as the carrier gas, showing that analysis of a diverse range of compounds was possible in the presence of oxygen. After exposure to dry air for 48 h at temperatures up to 220 °C, the µIL column's peak capacity was only degraded by 8.92%, which validated its long-term robustness against oxygen. The column's separation performance was not degraded by high moisture concentrations or long-term moisture exposure, also manifesting its robustness to moisture. The high temperature, moisture, and oxygen resilience of the µIL column enable more rapid separations in varying field environments without requiring additional µGC accessories (e.g., humidity filters and carrier gas cartridges). The µIL column is therefore expected to be useful for integration into future µGC devices. V.BACKGROUND Our transplant center recently expanded the acceptance criteria for cardiac donors to increase heart transplant volume. Our purpose was to assess the success of this strategy while maintaining acceptable 1-year survival. METHODS We retrospectively reviewed patients who underwent heart transplantation at our institution from January 2011 through December 2017. This time period was divided into 2 periods 2011 to 2014 (Period A) and 2015 to 2017 (Period B) because we implemented our new donor acceptance policy at the onset of 2015. We compared recipient and donor characteristics from the 2 time periods. The primary outcomes were 1-year graft and patient survival. RESULTS Transplant volume increased in Period B with the expanded donor acceptance policy 128 heart transplants over 36 months compared to 52 transplants in 48 months in Period A. Mean (± SD) recipient age was significantly higher in Period B (54 ± 12 vs 50 ± 15 years; P = .04) whereas other recipient variables were similar. Donors in Period B were significantly older, more likely to be female, had larger body mass index, were located a greater distance from the transplant center, and had a higher sequence number. Q-VD-Oph concentration Female donor to male recipient occurred more often in Period B than in Period A (27% vs 10%; P = .01). Both 1-year patient survival and graft survival were unchanged between Period B (95% for both) and Period A (96% for both). CONCLUSIONS Using a more aggressive donor acceptance policy allowed for an increase in heart transplant volume while maintaining acceptable 1-year graft and patient survival. BACKGROUND AND AIMS Preemptive kidney transplantation (PEKT) is recognized as the best therapy to avoid dialysis. However, it is not clear whether PEKT recipients experience an improvement in quality of life (QoL) after kidney transplantation (KT) that exceeds that of non-PEKT recipients, since PEKT recipients have not experienced the heavy burden of dialysis. The aim of this study was to compare the changes in QoL for PEKT and non-PEKT recipients following transplantation. METHODS Patients included in this study underwent living donor KT in our hospital. We excluded patients with incomplete SF-36 scores and with factors that could affect QoL, such as complications or rejection. QoL was assessed by the Short Form 36-Item Health Survey version 2.0 preoperatively and 3 and 12 months postoperatively. RESULTS Eighty-eight patients underwent living donor KT in our hospital. Twelve PEKT and 20 non-PEKT recipients were enrolled in this retrospective study. In the non-PEKT group, both the physical and mental domain scores dramatically improved from baseline at 3 months, and remained at a similar level at 12 months. In contrast, in the PEKT group, only 1 domain of the physical and mental score improved at 3 months, and the social functioning score gradually improved at 12 months. Although the mental component score showed significant improvement in the non-PEKT group, it did not change in the PEKT group. CONCLUSIONS The improvement of QoL after transplantation is more evident in the non-PEKT group. PEKT recipients have less mental satisfaction than non-PEKT recipients.
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