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Points of interest involving human embryonic improvement engraved within somatic variations.
The small-angle neutron scattering (SANS) on the chicken erythrocyte nuclei demonstrates the bifractal nature of the chromatin structural organization. Use of the contrast variation (D_2O-H_2O) in SANS measurements reveals the differences in the DNA and protein arrangements inside the chromatin substance. It is the DNA that serves as a framework that constitutes the bifractal behavior showing the mass fractal properties with D=2.22 at a smaller scale and the logarithmic fractal behavior with D≈3 at a larger scale. The protein spatial organization shows the mass fractal properties with D≈2.34 throughout the whole nucleus. The borderline between two fractal levels can be significantly shifted toward smaller scales by centrifugation of the nuclei disposed on the dry substrate, since nuclei suffer from mechanical stress transforming them to a disklike shape. The height of this disk measured by atomic force microscopy (AFM) coincides closely with the fractal borderline, thus characterizing two types of the chromatin with the soft (at larger scale) and rigid (at smaller scale) properties. The combined SANS and AFM measurements demonstrate the stress induced switch of the DNA fractal properties from the rigid, but loosely packed, mass fractal to the soft, but densely packed, logarithmic fractal.A run-and-tumble particle in a one-dimensional box (infinite potential well) is studied. The steady state is analytically solved and analyzed, revealing the emergent length scale of the boundary layer where particles accumulate near the walls. The mesoscopic steady state entropy production rate of the system is derived from coupled Fokker-Planck equations with a linear reaction term, resulting in an exact analytic expression. The entropy production density is shown to peak at the walls. Additionally, the derivative of the entropy production rate peaks at a system size proportional to the length scale of the accumulation boundary layer, suggesting that the behavior of the entropy production rate and its derivatives as a function of the control parameter may signify a qualitative behavior change in the physics of active systems, such as phase transitions.It is well known that suspensions of particles in a viscous fluid can affect the rheology significantly, producing a pronounced non-Newtonian response even in dilute suspension. However, it is unclear a priori which particle shapes lead to this behavior. We present two simple symmetry conditions on the shape which are sufficient for a dilute suspension to be Newtonian for all strain sizes and one sufficient for Newtonian behavior for small strains. Linsitinib IGF-1R inhibitor We also construct a class of shapes out of thin, rigid rods not found by the symmetry argument which share this property for small strains.The electrohydrodynamic response of a counterflow laminar diffusion flame to applied alternating current (ac) electric fields is investigated experimentally and numerically. The flame positions are observed to show typical response to applied ac electric fields with high and moderate frequencies. The flame position does not respond above a threshold frequency corresponding to a certain collision response time, below which it oscillates in phase with the applied electric field. At a very low frequency (less than approximately 1 Hz), however, the flame position is observed to vary nonmonotonically as a function of time. To elucidate the nonmonotonic behaviors, a one-dimensional ionic transport model was employed by applying time-dependent electric fields. The responses of flame positions for ionized layers substituting for counterflow diffusion flames were systematically investigated with respect to one-way ionic wind (OIW) and two-way ionic wind (TIW) models. Consequently, it is demonstrated that the ionic models can produce not only harmonic flame oscillations for relatively low ac frequencies, but also free flame oscillations for stepwise voltages, which originated from the interaction between electrostatic force and ionic wind-induced force in the ionic system for both the OIW and TIW models.In the context of stochastic thermodynamics, a minimal model for nonequilibrium steady states has been recently proposed the Brownian gyrator (BG). It describes the stochastic overdamped motion of a particle in a two-dimensional harmonic potential, as in the classic Ornstein-Uhlenbeck process, but considering the simultaneous presence of two independent thermal baths. When the two baths have different temperatures, the steady BG exhibits a rotating current, a clear signature of nonequilibrium dynamics. Here, we consider a time-dependent potential, and we apply a reverse-engineering approach to derive exactly the required protocol to switch from an initial steady state to a final steady state in a finite time τ. The protocol can be built by first choosing an arbitrary quasistatic counterpart, with few constraints, and then adding a finite-time contribution which only depends upon the chosen quasistatic form and which is of order 1/τ. We also get a condition for transformations which, in finite time, conserve internal energy, useful for applications such as the design of microscopic thermal engines. Our study extends finite-time stochastic thermodynamics to transformations connecting nonequilibrium steady states.We devise a simple method for detecting signals of unknown form buried in any noise, including heavy tailed. The method centers on signal-noise decomposition in rank and time Only stationary white noise generates data with a jointly uniform rank-time probability distribution, U(1,N)×U(1,N), for N data points in a time series. Signals of any kind distort this uniformity. Such distortions are captured by rank-time cumulative distributions permitting all-purpose efficient detection, even for single time series and noise of infinite variance.Prominent examples of longitudinal phase separation in elastic systems include elastic necking, the propagation of a bulge in a cylindrical party balloon, and the beading of a gel fiber subject to surface tension. Here we demonstrate that if the parameters of such a system are tuned near a critical point (where the difference between the two phases vanishes), then the behavior of all systems is given by the minimization of a simple and universal elastic energy familiar from Ginzburg-Landau theory in an external field. We minimize this energy analytically, which yields not only the well known interfacial tanh solution, but also the complete set of stable and unstable solutions in both finite and infinite length systems, unveiling the elastic system's full shape evolution and hysteresis. Correspondingly, we also find analytic results for the the delay of onset, changes in criticality, and ultimate suppression of instability with diminishing system length, demonstrating that our simple near-critical theory captures much of the complexity and choreography of far-from-critical systems.
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