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Tourette syndrome (TS) is often found comorbid with other neurodevelopmental disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) as most prevalent. This points to the possibility of a common etiological thread along an impulsivity-compulsivity continuum.
Investigating the shared genetic basis across TS, ADHD, ASD, and OCD, we undertook an evaluation of cross-disorder genetic architecture and systematic meta-analysis, integrating summary statistics from the latest genome-wide association studies (93,294 individuals, 6,788,510 markers).
As previously identified, a common unifying factor connects TS, ADHD, and ASD, while TS and OCD show the highest genetic correlation in pairwise testing among these disorders. Thanks to a more homogeneous set of disorders and a targeted approach that is guided by genetic correlations, we were able to identify multiple novel hits and regions that framework for research across traditional diagnostic categories.Under a theory of event representations that defines events as dynamic changes in objects across both time and space, as in the proposal of Intersecting Object Histories (Altmann & Ekves, 2019), the encoding of changes in state is a fundamental first step in building richer representations of events. In other words, there is an inherent dynamic that is captured by our knowledge of events. In the present study, we evaluated the degree to which this dynamic was inferable from just the linguistic signal, without access to visual, sensory, and embodied experience, using recurrent neural networks (RNNs). Recent literature exploring RNNs has largely focused on syntactic and semantic knowledge. We extend this domain of investigation to representations of events within RNNs. In three studies, we find preliminary evidence that RNNs capture, in their internal representations, the extent to which objects change states; for example, that chopping an onion changes the onion by more than just peeling the onion. Moreover, the temporal relationship between state changes is encoded to some extent. We found RNNs are sensitive to how chopping an onion and then weighing it, or first weighing it, entails the onion that is being weighed being in a different state depending on the adverb. Our final study explored what factors influence the propagation of these rudimentary event representations forward into subsequent sentences. We conclude that while there is much still to be learned about the abilities of RNNs (especially in respect of the extent to which they encode objects as specific tokens), we still do not know what are the equivalent representational dynamics in humans. That is, we take the perspective that the exploration of computational models points us to important questions about the nature of the human mind.Transient impulses caused by local defects are critical for the fault detection of rotating machines. However, they are extremely weak and overwhelmed in the strong noise and harmonic components, making the transient features are very difficult to be extracted. This paper proposes an adaptive multi-scale improved differential filter (AMIDIF) to enhance the identification of transient impulses for rotating machine fault diagnosis. In this scheme, firstly, the AMIDIF is performed to decompose the measured signal of rotating machine into a series of multi-scale improved differential filter (MIDIF) filtered signals. Subsequently, in view of the MIDIF filtered signals exhibit varying extents of validity in revealing fault features, a weighted reconstruction method using correlation analysis is proposed in which the weighted coefficients are counted and distributed to the corresponding MIDIF filtered signals to highlight the effective MIDIF filtered signals and weaken the invalid ones. Finally, the transient impulse components of rotating machinery are obtained by multiplying the weighted coefficients and the MIDIF filtered signals under different scales. Furthermore, the fault types of rotating machines are inferred from the fault defect frequencies in the envelope spectrum of the transient impulses. Simulation analysis and experimental studies are implemented to verify the performance of the AMIDIF compared with the state-of-the-art methods including spectral kurtosis (SK), multi-scale average combination different morphological filter (ACDIF) and multi-scale morphology gradient product operation (MGPO). The results prove that the AMIDIF has excellent performance in extracting transient features for rotating machines fault diagnosis.Recently, substantial research has explored the development of deep-learning-based methods to diagnose faults in rotating machinery. For these diagnosis methods, it is difficult to obtain high target diagnosis accuracy when the amount of labeled data obtained pertaining to the rotating machinery under study is insufficient or in cases involving a discrepancy in the distribution types found in the training and test data sets. To deal with this research need, the paper outlines a new method, a domain adaptation with semantic clustering (DASC), capable of diagnosing faults in rotating machinery. The method outlined in this research learns both domain-invariant and discriminative features. The method reduces the domain discrepancy by minimizing the domain-related loss. In addition, by defining an additional loss, which is called semantic clustering loss, and reducing it at multiple feature levels, the DASC method learns features that make samples better semantically clustered, according to their health conditions. Consequently, fault diagnosis performance for target rotating machinery can be enhanced through the use of the DASC approach. The effectiveness of the DASC approach is confirmed by examining various fault diagnosis situations with domain discrepancies across the source and target domains, using experimental data from three bearing systems. Also, various analyses are explored to better understand the advantages of the DASC method.
To assess differences in qualitative and quantitative parameters of pulmonary perfusion from dual-energy computed tomography (CT) pulmonary angiography (DECT-PA) in patients with COVID-19 pneumonia with and without pulmonary embolism (PE).
This retrospective institutional review board-approved study included 74 patients (mean age 61±18 years, malefemale 3440) with COVID-19 pneumonia in two countries (one with 68 patients, and the other with six patients) who underwent DECT-PA on either dual-source (DS) or single-source (SS) multidetector CT machines. Images from DS-DECT-PA were processed to obtain virtual mono-energetic 40 keV (Mono40), material decomposition iodine (MDI) images and quantitative perfusion statistics (QPS). Two thoracic radiologists determined CT severity scores based on type and extent of pulmonary opacities, assessed presence of PE, and pulmonary parenchymal perfusion on MDI images. SCH727965 The QPS were calculated from the CT Lung Isolation prototype (Siemens). The correlated clinical outcomes included duration of hospital stay, intubation, SpO
and death.
Website: https://www.selleckchem.com/products/dinaciclib-sch727965.html
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