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Crystal-Induced Podocytopathy Producing Falling apart Focal Segmental Glomerulosclerosis in Monoclonal Gammopathy regarding Renal Importance: A Case Document.
The presence of pharmaceuticals and personal care products (PPCPs) has become a global concern, as it poses a threat to the environment, especially to the aquatic ecosystem. This study focused on 30 PPCPs found in the Baiyangdian basin of the Xiong'an New Area, in the core of Beijing-Tianjin-Hebei region, with intensive human interventions during two seasons. In general, 30 PPCPs were all frequently detected, ranging from 42.3 to 7710 ng/L in May and 48.9 to 1300 ng/L in November. Sulfamethoxazole, ofloxacin, anhydro-erythromycin, carbamazepine, caffeine, and were screened as the predominant PPCPs. The rivers input was an essential source of PPCPs. The source apportionment with a series of analytical methods revealed that domestic sewage was the primary source, and untreated water also crucial for PPCPs contamination. The risk assessment suggested carbamazepine, caffeine, ofloxacin, and anhydro-erythromycin exhibited relatively high ecological risks for protecting most species such as algae, fish, and flowers in the aquatic ecosystem, especially near the outlet of WWTPs. Thus, management strategies for such PPCPs will be needed. Intensive human interventions, including a prohibition of fish breeding, water diversion project, and wastewater treatment in villages, were having an effective role in alleviating PPCPs contamination.The source of fine particulate matter (PM2.5) has been a longstanding subject of debate, the nitrogen-15 isotope (δ15N) has been used to identify the major sources of atmospheric nitrogen. In this study, PM2.5 samples (n = 361) were collected from September 2017 to August 2018 in the urban area of Guiyang (SW, China), to investigate the chemical composition and potential sources of PM2.5. The results showed an average PM2.5 of 33.0 μg m-3 ± 20.0 μg m-3. The concentration of PM2.5 was higher in Winter, lower in Summer. The major water resolved inorganic ions (WSIIs) were Ca2+, NH4+, Na+, SO42-, NO3-, Cl-. Nitrogen-containing aerosols (i.e., NO3- and NH4+) suddenly strengthened during the winter, when NO3- became the dominant contributor. Over the sampling period, the molar ratio of NH4+/(NO3- + 2 × SO42-) ranged from 0.1 to 0.9, thus indicating the full fixation of NH4+ by existing NO3- and SO42- in PM2.5. The annual value of NOR was 0.1 while rised to 0.5 in Winter. The variations of NOR (Nitrogen oxidation ratio) (0.1-0.5) values suggest that the secondary formation of NO3- occurred every season and was most influential during the winter. The total particulate nitrogen (TN) δ15N value of PM2.5 ranged from -5.9‰ to 25.3‰ over the year with annual mean of +11.8‰ ± 4.7‰, whereas it was between -5.9‰ and 14.3‰ during the winter with mean of 7.0‰ ± 3.8‰. A Bayesian isotope mixing model (Stable Isotope Analysis in R; SIAR) was applied to analyze the nitrogen sources. The modeling results showed that 29%, 21%, and 40% of TN in PM2.5 during the winter in Guiyang was due to nitrogen-emissions from coal combustion, vehicle exhausts, and biomass burning, respectively. Our results demonstrate that biomass burning was the main contributor to PM during the winter, 80% of the air mass comes from rural areas of Guizhou border, this transport process can increase the risk of particulate pollution in Guiyang.Polycyclic aromatic hydrocarbons (PAHs) pollution as well as the emissions of nitric oxide (NO) and greenhouse gas nitrous oxide (N2O) in denitrification processes are currently two environmental issues of great concern. Although bioremediation of PAHs under denitrification is considered a promising approach, denitrification was an important contributor to N2O and NO emissions. This long-term study confirmed for the first time that microorganisms could utilize NO to efficiently degrade phenanthrene and fluoranthene. Lirafugratinib When the two systems of NO-dependent phenanthrene and fluoranthene degradation were stable, the first-order rate constants of phenanthrene and fluoranthene in the two systems (0.1940 and 0.0825 day-1, respectively) were close to those values (0.2290 and 0.1085 day-1, respectively) observed at nitrate-reducing conditions. Further analysis of functional genes revealed that phenanthrene and fluoranthene might be degraded under the combined action of the anaerobic pathway mediated by NO reduction and intra-aerobic pathway mediated by NO dismutation. The genomic analysis showed that Nod genes had high diversity and most of them were similar to aquifer cluster group in the two systems. Microbial community structure analysis indicated that Pseudomonas and Ochrobactrum might be key participants in NO-dependent phenanthrene degradation system, and Azoarcus, Alicycliphilus and Moheibacter might play vital roles in NO-dependent fluoranthene degradation system. This study provides new perspective for anaerobic remediation of PAH pollution and simultaneously reducing NO and N2O emissions during bioprocesses, which has important ecological significance for amending sediment and soil PAHs contamination and potential application for the removal of PAHs in flue gas.In this study, we investigated the bioavailability and toxicity of metals (Cu and Ni) in the soil containing polyethylene microplastics (PE-MPs). The bioavailability of the metals determined by the five-step chemical sequential extraction method increased with the addition of MPs (0.1%, 1%, 10%) in the soil, which was confirmed by the adsorption-desorption characteristics. To further examine the bioavailability and toxicity of metals, earthworms (Eisenia fetida) were exposed to soil containing Cu2+ (100 mg/kg) or Ni2+ (40 mg/kg) with different amounts (0.01%, 0.05%, and 0.1%) of PE-MPs for 21 days. The highest concentrations of Cu2+ and Ni2+ in earthworms reached to 73.3 and 36.3 mg/kg, respectively. Moreover, metal concentrations in earthworms increased with MP contents in the soil, which was consistent with the bioavailability measured by the sequential extraction method. Furthermore, changes in biomarkers including peroxidase (POD), catalase (CAT) and superoxide dismutase (SOD) activity, malondialdehyde (MDA) contents, and related gene expression levels in earthworms suggested that the pollutants caused toxicity to earthworms. Overall, MPs increased the bioavailability of metals in the soil and the toxic effects to earthworms. These findings provide insights regarding the impacts of MPs on the bioavailability of metals and the combined toxic effects of these two kinds of pollutants on terrestrial animals.
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