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Large cardiovascular myxoma in a affected individual along with thrombocytopenia: is there a physiopathologic link? (a case document).
Computed Tomography (CT) plays an important role in lung malignancy diagnostics, therapy assessment, and facilitating precision medicine delivery. However, the use of personalized imaging protocols poses a challenge in large-scale cross-center CT image radiomic studies. Oxaliplatin cell line We present an end-to-end solution called STAN-CT for CT image standardization and normalization, which effectively reduces discrepancies in image features caused by using different imaging protocols or using different CT scanners with the same imaging protocol. STAN-CT consists oftwo components 1)a Generative Adversarial Networks (GAN) model where a latent-feature-based loss function is adopted to learn the data distribution of standard images within a few rounds of generator training, and 2) an automatic DICOM reconstruction pipeline with systematic image quality control that ensures the generation ofhigh-quality standard DICOM images. Experimental results indicate that the training efficiency and model performance of STAN-CT have been significantly improved compared to the state-of-the-art CT image standardization and normalization algorithms.Objective Brain functional connectivity measures are often used to study interactions between brain regions in various neurological disorders such as epilepsy. In particular, functional connectivity measures derived from high resolution electrophysiological signal data have been used to characterize epileptic networks in epilepsy patients. However, existing signal data formats as well as computational methods are not suitable for complex multi-step methods used for processing and analyzing signal data across multiple seizure events. To address the significant data management challenges associated with signal data, we have developed a new workflow-based tool called NeuroIntegrative Connectivity (NIC) using the Cloudwave Signal Format (CSF) as a common data abstraction model. Method The NIC compositional workflow-based tool consists of (1) Signal data processing component for automated pre- processing and generation of CSF files with semantic annotation using epilepsy domain ontology; and (2) Functional networkl changes in epileptic networks in patient cohort studies.Phenotyping algorithms are essential tools for conducting clinical research on observational data. Manually devel- oped phenotyping algorithms, such as those curated within the eMERGE (electronic Medical Records and Genomics) Network, represent the gold standard but are time consuming to create. In this work, we propose a framework for learning from the structure of eMERGE phenotype concept sets to assist construction of novel phenotype definitions. We use eMERGE phenotypes as a source of reference concept sets and engineer rich features characterizing the con- cept pairs within each set. We treat these pairwise relationships as edges in a concept graph, train models to perform edge prediction, and identify candidate phenotype concept sets as highly connected subgraphs. Candidate concept sets may then be interrogated and composed to construct novel phenotype definitions.Significant investments have been made in patient portals in order to provide patients with greater access to their medical records, as well as to other services such as secure electronic communication with their healthcare provider(s). Unfortunately, overall, patient adoption and use of patient portals has been lower than expected. According to the user-centered design philosophy, including end-user voices in all stages of the design process is critical to a technology's success. Thus, as a part of a larger systematic review, we examined the patient portal literature and identified 42 studies that reported patient's or their caregiver's suggestions to improve patient portals. The results suggest that patients and caregivers want patient portals to (i) support human connection (e.g., virtual patient-provider interactions), (ii) give patients more control (e.g., over their medical record) and be designedfor the variation in patient and caregiver experiences, and (iii) be innovative (e.g., provide contextualized medical advice).Recent medical prognostic models adapted from high data-resource fields like language processing have quickly grown in complexity and size. However, since medical data typically constitute low data-resource settings, performances on tasks like clinical prediction did not improve expectedly. Instead of following this trend of using complex neural models in combination with small, pre-selected feature sets, we propose EffiCare, which focuses on minimizing hospital resource requirements for assistive clinical prediction models. First, by embedding medical events, we eliminate manual domain feature-engineering and increase the amount oflearning data. Second, we use small, but data-efficient models, that compute faster and are easier to interpret. We evaluate our approach on four clinical prediction tasks and achieve substantial performance improvements over highly resource-demanding state-of-the-art methods. Finally, to evaluate our model beyond score improvements, we apply explainability and interpretability methods to analyze the decisions of our model and whether it uses data sources and parameters efficiently.1.Primary care represents a major opportunity for suicide prevention in the military. Significant advances have been made in using electronic health record data to predict suicide attempts in patient populations. With a user-centered design approach, we are developing an intervention that uses predictive analytics to inform care teams about their patients' risk of suicide attempt. We present our experience working with clinicians and staff in a military primary care setting to create preliminary designs and a context-specific usability testing plan for the deployment of the suicide risk indicator.Clinical judgment studies are an integral part of drug safety surveillance and pharmacovigilance frameworks. They help quantify the causal relationship between medication and its adverse drug reactions (ADRs). To conduct such studies, physicians need to review patients' charts manually to answer Naranjo questionnaire1. In this paper, we propose a methodology to automatically infer causal relations from patients' discharge summaries by combining the capabilities of deep learning and statistical learning models. We use Bidirectional Encoder Representations from Transformers (BERT)2 to extract relevant paragraphs for each Naranjo question and then use a statistical learning model such as logistic regression to predict the Naranjo score and the causal relation between the medication and an ADR. Our methodology achieves a macro-averaged f1-score of 0.50 and weighted f1-score of 0.63.
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