Notes

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Also, EA improved the CCI-induced depression-like behaviors, and significantly reversed the down-regulation of BDNF and 5-HT expression in the ACC and spinal cord after CCI. Furthermore, EA regulated the level of CREB in the ACCs and spinal cords of mice.

These results suggested that the analgesic and antidepressant effect of EA is achieved through regulating CREB-5-HT/BDNF signaling pathway in the ACCs and spinal cords of mice.
These results suggested that the analgesic and antidepressant effect of EA is achieved through regulating CREB-5-HT/BDNF signaling pathway in the ACCs and spinal cords of mice.
The corona virus disease 2019 (COVID-19) pandemic has required specialist palliative care (SPC) services to respond by (I) integrating infection prevention/control measures into care for their usual caseloads and (II) providing consultations and/or care for people dying from a new disease entity. The aim of the current study was to learn about the response of Australian SPC services to COVID-19 and its consequences in order to inform pandemic practice and policy.

A cross-sectional, anonymous survey was administered online from May to July 2020. Email invitations were sent to 160 providers delivering 503 SPC services listed in the Australian Palliative Care Services Directory. Survey questions asked about service responses to COVID-19, impacts on care quality, and perceived benefits/disadvantages for palliative care clients post-pandemic. Open-ended responses were thematically coded using an established framework that classifies SPC pandemic responses under 'stuff', 'staff', 'space', 'systems', 'separationion of telehealth during the pandemic presents an opportunity for leveraging to benefit palliative care longer term.
Meeting COVID-19-related challenges requires SPC to be agile and responsive. Advocacy is required to ensure the needs of people dying and their families are supported as well as people requiring acute care for COVID-19. Expansion of telehealth during the pandemic presents an opportunity for leveraging to benefit palliative care longer term.
In order to improve the postoperative decompression and drainage of large mandibular cysts after fenestration decompression, a new drainage plug was designed and its feasibility for clinical application was explored.

A total of 74 patients with large mandibular cysts requiring fenestration decompression were included and randomly divided into the control group (n=34) and model group (n=40). Borussertib nmr Patients in the control group were given a conventional plug, while patients in the model group were given the new silicone drainage plug. The drainage plug mold was printed using 3D printing technology. Subsequently, the mold was filled with silicone material and the drainage tube was placed into the mold to make a drainage plug. The clinical effect of the new drainage plug was assessed, and the postoperative recovery time was compared between the 2 groups.

In the model group, the average wear time of the new drainage plug was approximately 13 months. Compared with the control group, the course of treatment in the model group was shortened by approximately 5 months, with a better fit, less food debris, and easier installation and removal.

The new drainage plug provides more convenience and better prognosis for patients after fenestration decompression, and holds great promise for clinical application.
The new drainage plug provides more convenience and better prognosis for patients after fenestration decompression, and holds great promise for clinical application.
The role of locoregional radiotherapy (LRT) of the nasopharynx and neck in patients with metastatic nasopharyngeal carcinoma (M-NPC) remains unclear. The present meta-analysis aimed to compare the efficacy of chemotherapy (CT) plus LRT with CT alone in M-NPC patients.

Eligible manuscripts were searched in the following electronic databases Cochrane Library, Embase, and PubMed. The hazard ratio (HR) of overall survival (OS) and progression-free survival (PFS), and the risk ratio (RR) of the objective response rate (ORR) and disease control rate (DCR) were pooled and expressed with the 95% confidence intervals (CIs). The analysis was conducted using Review Manager and Stata software.

In total 15 retrospective studies and 1 randomized controlled trial were identified comparing 3,402 M-NPC patients of whom 1,387 received CT alone and 2,015 were treated with CT plus LRT. The adjusted HR of OS for CT plus LRT compared with CT alone was 0.45 (95% CI 0.40-0.52), while the pooled HR of PFS was 0.37 (95% CI 0.29-0.49). The pooled RR of ORR and DCR for CT plus LRT compared with CT alone was 0.60 (95% CI 0.46-0.79) and 0.77 (95% CI 0.71-0.85), respectively. Heterogeneity or publication bias in the studies was not found to have altered the conclusion.

For patients with M-NPC, CT + LRT is superior to CT alone providing the higher OS, PFS, ORR, and DCR compared with CT alone. CT combined with LRT should be recommended as a more suitable choice for M-NPC patients.
For patients with M-NPC, CT + LRT is superior to CT alone providing the higher OS, PFS, ORR, and DCR compared with CT alone. CT combined with LRT should be recommended as a more suitable choice for M-NPC patients.
Within the generalist-plus-specialist palliative care model, palliative care is mainly provided by nurses and physicians of hospital primary care teams. Palliative care consultation teams (PCCTs) support these clinicians in adequately caring for patients with advanced illnesses. Our team started in 2012. The aim of this study was to assess the self-perceived barriers, educational needs and awareness of available palliative care support options among our hospital primary care teams. In addition, palliative care referral patterns were evaluated.

Single-center mixed methods study. Outcomes of two surveys of primary care team clinicians (2012 and 2016) on barriers to palliative care, educational needs and awareness of palliative care support options were compared (chi-square, Mann-Whitney U tests, qualitative analysis). Palliative care referral characteristics were evaluated (2012-2017), including referral timing (survival since referral) (descriptive statistics, Kaplan-Meier methodology). Predictions of survival at referral were analyzed (weighted Kappa).
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