Notes

AI-Empowered Computational Study of Chest Imaging regarding COVID-19 Treatment: An assessment.
27, p=0.03) and sleep latency (t=-2.40, p=0.03) as compared to the DL-exposed group. In addition, functional connectivity decreased in the cluster that encompasses the right anterior insular and the frontal opercular regions in the salience network (uncorrected p<0.001, cluster size>100mm
) in the BL-exposed group. Decreased functional connectivity in the cluster was associated with decreased sleep latency in the BL-exposed group (β=0.54, p=0.01).

Our results suggest that bright light exposure may improve sleep quality in individuals with sleep disturbances by modulating functional connectivity in the salience network.

https//cris.nih.go.kr/cris; KCT0002607.
https//cris.nih.go.kr/cris; KCT0002607.
Cystic fibrosis (CF) is a life-shortening, genetic disease that affects approximately 30,000 Americans. Although patients frequently report snoring, mouth breathing, and insomnia, the extent to which sleep-disordered breathing (SDB) may underlie these complaints remains unknown.

Single-center retrospective review of polysomnography results from referred patients with and without CF individually-matched (12) for age, gender, race, and body mass index (BMI).

Mean ages were 8.0±5.2 (sd) and 35.9±12.9 years, among 29 children and 23 adults with CF respectively. The CF and non-CF groups were well-matched in age and BMI. Subjects with vs. without CF had three times greater odds of moderate-severe SDB (apnea-hypopnea index (AHI)≥5 in children, ≥ 15 in adults) (p=0.01). Nocturnal oxygen saturation nadir (Minimum SpO
) was lower among CF vs. non-CF groups (p=0.002). For every 1-unit increase in AHI, the decline in Minimum SpO
was larger for subjects with vs. without CF (p=0.05). In subjects with CF, forced expiratory volume in 1s percent predicted (FEV1 PPD) was associated with Minimum SpO
(Pearson r=0.68, p<0.0001) but not AHI (r=-0.19, p=0.27). For every 1-unit increase in AHI, magnitude of decline in Minimum SpO
was larger for those with low vs. normal FEV1 PPD (p=0.01).

Severity of SDB may be worse among referred patients with vs. without CF. The SDB may modify the relationship between CF lung disease and nocturnal hypoxemia. Markers of lung disease severity including lung function do not predict SDB severity, suggesting the need for routine polysomnography to screen for this sleep disorder.
Severity of SDB may be worse among referred patients with vs. without CF. The SDB may modify the relationship between CF lung disease and nocturnal hypoxemia. Markers of lung disease severity including lung function do not predict SDB severity, suggesting the need for routine polysomnography to screen for this sleep disorder.
To evaluate the incidence of iron overload and anaphylaxis following intravenous (IV) iron treatment of restless legs syndrome (RLS).

A total of 58 consecutive RLS patients, meeting clinical requirements for IV iron treatment according to current IRLSSG guidelines were recruited. IV iron treatment consisted of two 500mg infusions of ferric carboxymaltose (FCM) administered five days apart. During each of the three follow-up visits we obtained blood samples, substantia nigra echogenity index (SNEI) by means of transcranial sonography (TCS), and assessed the severity of RLS symptoms (IRLS scale). "Iron overload risk" was defined as transferrin saturation (TSAT)>45% on two consecutive follow-up visits. In patients who had a reduction in systemic iron levels following treatment, an additional 500mg of FCM was administered when feasible. In such cases an additional two follow-up visits were performed.

Among the total sample, only 2/58 participants met criteria for iron overload risk. They had no evidence of liver damage and did not require additional treatment. Among the 21 patients receiving an additional 500mg infusion after, only one patient was diagnosed with iron overload risk. Among these three patients, only one was a hemochromatosis gene carrier. No anaphylaxis or other side-effects were reported.

In real-life clinical conditions, the risk of iron overload is low when IV FCM is administered according to the safety limits defined in the current RLS treatment guidelines. However, a close clinical follow-up with periodic blood sampling for iron status, is needed.
In real-life clinical conditions, the risk of iron overload is low when IV FCM is administered according to the safety limits defined in the current RLS treatment guidelines. SGI-1776 However, a close clinical follow-up with periodic blood sampling for iron status, is needed.
Low adherence impairs the effectiveness of continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA), but knowledge on CPAP usage micro-patterns is mostly lacking. Thus, the aim of this study was to analyse usage micro-patterns among patients with suboptimal CPAP adherence.

We analysed CPAP usage datasets comprising the initial 31 nights of therapy. By employing a threshold of 4h usage in at least 70% of nights, we subdivided the patients into suboptimal and optimal users. We investigated single CPAP start- and stop-points, and introduced the parameter "interruption-rate", by dividing the amount of therapy interruptions per night by the usage duration per night. This parameter represents the amount of interruptions per 1h of CPAP usage. Group comparison analysis was performed via t-test, Wilcoxon rank sum-test, and via Chi
-test.

We included datasets of 48 suboptimal and 48 optimal users (55.9±11.3 years, 83.3% men) in the analysis. Interruption-rate was significantly higher among suboptimal users, when compared with optimal users (median (quartiles) 0.24 (0.14/0.45) versus 0.15 (0.05/0.28), p<0.001∗). Suboptimal users were more likely to report that CPAP reduced their sleep quality, waked them up at night, and that CPAP side effects or problems with the device impaired their adherence.

CPAP usage micro-patterns are more fragmented among OSA patients with lower overall adherence. These patterns might result from impaired sleep quality, due to CPAP side effects, and device-associated problems.
CPAP usage micro-patterns are more fragmented among OSA patients with lower overall adherence. These patterns might result from impaired sleep quality, due to CPAP side effects, and device-associated problems.
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