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Synergistic Connection between Morphological Manage and Contrasting Absorption within Productive All-Small-Molecule Ternary-Blend Cells.
The distribution of Se in grain of the high-Se rice cultivar was more uniform, whereas the low-Se cultivar tended to accumulate Se in embryo end. WM-1119 molecular weight The stronger reutilization of Se from shoots to grains promoted by increased transporters genes expression and optimized grain storage space may explain how the high-Se rice cultivar is able to accumulate more Se in grain.Immense amount of high-content image data generated in drug discovery screening requires computationally driven automated analysis. Emergence of advanced machine learning algorithms, like deep learning models, has transformed the interpretation and analysis of imaging data. However, deep learning methods generally require large number of high-quality data samples, which could be limited during preclinical investigations. To address this issue, we propose a generative modeling based computational framework to synthesize images, which can be used for phenotypic profiling of perturbations induced by drug compounds. We investigated the use of three variants of Generative Adversarial Network (GAN) in our framework, viz., a basic Vanilla GAN, Deep Convolutional GAN (DCGAN) and Progressive GAN (ProGAN), and found DCGAN to be most efficient in generating realistic synthetic images. A pre-trained convolutional neural network (CNN) was used to extract features of both real and synthetic images, followed by a classification model trained on real and synthetic images. The quality of synthesized images was evaluated by comparing their feature distributions with that of real images. The DCGAN-based framework was applied to high-content image data from a drug screen to synthesize high-quality cellular images, which were used to augment the real image data. The augmented dataset was shown to yield better classification performance compared with that obtained using only real images. We also demonstrated the application of proposed method on the generation of bacterial images and computed feature distributions for bacterial images specific to different drug treatments. In summary, our results showed that the proposed DCGAN-based framework can be utilized to generate realistic synthetic high-content images, thus enabling the study of drug-induced effects on cells and bacteria.This paper concentrates on the exponential synchronization problem of the delayed neural networks (DNNs) with stochastic impulses. First, the impulsive Halanay differential inequality is further extended to the case that the impulsive strengths are random variables. Then, based on the generalized inequalities, synchronization criteria are respectively proposed for DNNs with two kinds of stochastic impulses, i.e., impulses with independent property/Markovian property. It should be pointed out that only some basic statistical characteristics are needed to verify the proposed criteria. Numerical examples are provided to show the validation of the obtained theoretical results at the end of this paper.The goal of zero-shot learning (ZSL) is to build a classifier that recognizes novel categories with no corresponding annotated training data. The typical routine is to transfer knowledge from seen classes to unseen ones by learning a visual-semantic embedding. Existing multi-label zero-shot learning approaches either ignore correlations among labels, suffer from large label combinations, or learn the embedding using only local or global visual features. In this paper, we propose a Graph Convolution Networks based Multi-label Zero-Shot Learning model, abbreviated as MZSL-GCN. Our model first constructs a label relation graph using label co-occurrences and compensates the absence of unseen labels in the training phase by semantic similarity. It then takes the graph and the word embedding of each seen (unseen) label as inputs to the GCN to learn the label semantic embedding, and to obtain a set of inter-dependent object classifiers. MZSL-GCN simultaneously trains another attention network to learn compatible local and global visual features of objects with respect to the classifiers, and thus makes the whole network end-to-end trainable. In addition, the use of unlabeled training data can reduce the bias toward seen labels and boost the generalization ability. Experimental results on benchmark datasets show that our MZSL-GCN competes with state-of-the-art approaches.Brain tumors are one of the major common causes of cancer-related death, worldwide. Growth prediction of these tumors, particularly gliomas which are the most dominant type, can be quite useful to improve treatment planning, quantify tumor aggressiveness, and estimate patients' survival time towards precision medicine. Studying tumor growth prediction basically requires multiple time points of single or multimodal medical images of the same patient. Recent models are based on complex mathematical formulations that basically rely on a system of partial differential equations, e.g. reaction diffusion model, to capture the diffusion and proliferation of tumor cells in the surrounding tissue. However, these models usually have small number of parameters that are insufficient to capture different patterns and other characteristics of the tumors. In addition, such models consider tumor growth independently for each subject, not being able to get benefit from possible common growth patterns existed in the whole population under study. In this paper, we propose a novel data-driven method via stacked 3D generative adversarial networks (GANs), named GP-GAN, for growth prediction of glioma. Specifically, we use stacked conditional GANs with a novel objective function that includes both l1 and Dice losses. Moreover, we use segmented feature maps to guide the generator for better generated images. Our generator is designed based on a modified 3D U-Net architecture with skip connections to combine hierarchical features and thus have a better generated image. The proposed method is trained and tested on 18 subjects with 3 time points (9 subjects from collaborative hospital and 9 subjects from BRATS 2014 dataset). Results show that our proposed GP-GAN outperforms state-of-the-art methods for glioma growth prediction and attain average Jaccard index and Dice coefficient of 78.97% and 88.26%, respectively.
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