Notes

Amazing period coherence length within epitaxial halide perovskites.
The growing use of vibrotactile signaling devices makes it important to understand the perceptual limits on vibrotactile information processing. To promote that understanding, we carried out a pair of experiments on vibrotactile, auditory, and bimodal (synchronous vibrotactile and auditory) temporal acuity. On each trial, subjects experienced a set of isochronous, standard intervals (400 ms each), followed by one interval of variable duration (400 ± 1-80 ms). Intervals were demarcated by short vibrotactile, auditory, or bimodal pulses. Subjects categorized the timing of the last interval by describing the final pulse as either "early" or "late" relative to its predecessors. In Experiment 1, each trial contained three isochronous standard intervals, followed by an interval of variable length. In Experiment 2, the number of isochronous standard intervals per trial varied, from one to four. Psychometric modeling revealed that vibrotactile stimulation produced poorer temporal discrimination than either auditory or bimodal stimulation. Moreover, auditory signals dominated bimodal sensitivity, and inter-individual differences in temporal discriminability were reduced with bimodal stimulation. Additionally, varying the number of isochronous intervals in a trial failed to improve temporal sensitivity in either modality, suggesting that memory played a key role in judgments of interval duration.Holistic processing has been shown with both faces and words, but it is unclear how similar their underlying mechanisms are. In this study attention to global and local features was manipulated and the consequences for holistic word and face processing were examined. On each trial participants were presented two Navon figures and told to focus on either the global or the local level. Then they performed a composite task in which they indicated whether the target halves of two sequentially presented faces or words were the same or different, ignoring the irrelevant halves. Similar stronger global priming effects were found for faces and words, indicating that holistic processing for the two types of stimuli were susceptible to attention manipulations to similar degrees, which was confirmed with Bayesian analyses. The findings add to the investigation of the similarity and differences between holistic processing and help reveal those aspects of holistic processing that are domain general and those specific to individual categories.
Echocardiographic surveillance for asymptomatic left ventricular systolic dysfunction (ALVSD) is advised in childhood cancer survivors (CCS), because of their risk of heart failure after anthracycline treatment. ALVSD can be assessed with different echocardiographic parameters. We systematically reviewed the prevalence and risk factors of late ALVSD, as defined by contemporary and more traditional echocardiographic parameters.

We searched databases from 2001 to 2020 for studies on ≥ 100 asymptomatic 5-year CCS treated with anthracyclines, with or without radiotherapy involving the heart region. Outcomes of interest were prevalence of ALVSD-measured with volumetric methods (ejection fraction; LVEF), myocardial strain, or linear methods (fractional shortening; FS)-and its risk factors from multivariable analyses.

Eleven included studies represented 3840 CCS. All studies had methodological limitations. An LVEF < 50% was observed in three studies in 1-6% of CCS, and reduced global longitudinal strain (GLS) was reported in three studies in 9-30% of CCS, both after a median follow-up of 9 to 23 years. GLS was abnormal in 20-28% of subjects with normal LVEF. Abnormal FS was reported in six studies in 0.3-30% of CCS, defined with various cut-off values (< 25 to < 30%), at a median follow-up of 10 to 18 years. Across echocardiographic parameters, reported risk factors were cumulative anthracycline dose and radiotherapy involving the heart region, with no 'safe' dose for ALVSD.

GLS identifies higher prevalence of ALVSD in anthracycline-treated CCS, than LVEF.

The diagnostic and prognostic value of GLS should be evaluated within large cohorts.

PROSPERO CRD42019126588.
PROSPERO CRD42019126588.
Coronary artery disease (CAD) risk prediction tools are useful decision supports. Their clinical impact has not been evaluated amongst Asians in primary care.

We aimed to develop and validate a diagnostic prediction model for CAD in Southeast Asians by comparing it against three existing tools.

We prospectively recruited patients presenting to primary care for chest pain between July 2013 and December 2016. CAD was diagnosed at tertiary institution and adjudicated. A logistic regression model was built, with validation by resampling. We validated the Duke Clinical Score (DCS), CAD Consortium Score (CCS), and Marburg Heart Score (MHS).

Discrimination and calibration quantify model performance, while net reclassification improvement and net benefit provide clinical insights.

CAD prevalence was 9.5% (158 of 1658 patients). Our model included age, gender, type 2 diabetes mellitus, hypertension, smoking, chest pain type, neck radiation, Q waves, and ST-T changes. The C-statistic was 0.808 (95% CI 0.776-0.840) and 0.815 (95% CI 0.782-0.847), for model without and with ECG respectively. C-statistics for DCS, CCS-basic, CCS-clinical, and MHS were 0.795 (95% CI 0.759-0.831), 0.756 (95% CI 0.717-0.794), 0.787 (95% CI 0.752-0.823), and 0.661 (95% CI 0.621-0.701). Our model (with ECG) correctly reclassified 100% of patients when compared with DCS and CCS-clinical respectively. At 5% threshold probability, the net benefit for our model (with ECG) was 0.063. Selleck NVP-CGM097 The net benefit for DCS, CCS-basic, and CCS-clinical was 0.056, 0.060, and 0.065.

PRECISE (Predictive Risk scorE for CAD In Southeast Asians with chEst pain) performs well and demonstrates utility as a clinical decision support for diagnosing CAD among Southeast Asians.
PRECISE (Predictive Risk scorE for CAD In Southeast Asians with chEst pain) performs well and demonstrates utility as a clinical decision support for diagnosing CAD among Southeast Asians.
High blood pressure is the most common chronic condition among US veterans. Blood pressure control is essential to preventing and managing cardiovascular diseases. While depressive symptoms are a known risk factor for uncontrolled blood pressure and veterans experience high rates of depressive symptoms, no research has examined the relationship between depressive symptoms and blood pressure control among US veterans.

We examined whether moderately severe-to-severe depressive symptoms, compared to none-to-minimal, are associated with higher risk of uncontrolled blood pressure among US veterans.

We analyzed a population-based sample of veterans from the National Health and Nutrition Examination Survey (2013-2016). Logistic regression models were adjusted for marital status, age, and body mass index. All analyses were weighted; results are generalizable to US veterans.

A sample of 864 veterans was analyzed, representing approximately 18.8 million US veterans.

Depressive symptoms were assessed by the Patient Health Questionnaire-9.
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