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Refractory otomycosis is a common condition that is difficult to treat.
This study aimed to evaluate the effectiveness of 1% topical voriconazole drops in the treatment of otomycosis.
This retrospective analysis was conducted from November 2017 to November 2019. Patients who had refractory otomycosis without tympanic membrane perforation confirmed by microbial culture and fluorescent staining were included in the study. All patients were treated with 1% topical voriconazole drops hourly at daytime for 2 weeks. Evaluation of effectiveness was conducted 1 month after the completion of topical voriconazole treatment. Before and after topical voriconazole treatment, hearing tests were performed in all patients.
Fifty-five patients were included in this study. The reasons for refractoriness were resistant recurrence to imidazole drugs (50 cases, 90.9%) and difficulty in cleaning the external auditory canal (5 cases, 9.1%). The most common strain was
(50.9%), followed by
(29.1%),
(10.9%), and
(9.1%). After 2 weeks of treatment with 1% topical voriconazole drops, otomycosis in all patients was resolved. There was no significant change in bone conduction before and after topical voriconazole treatment (paired
-test,
= 0.5023; linear correlation analysis,
= 0.98; equation,
= 1.003
-0.284). Adverse effects, such as blurred vision and phototoxicity, were not observed in any patient.
Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation within 2 weeks.
Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation within 2 weeks.Left ventricular (LV) structural remodeling following athletic training has been evidenced through training-specific changes in wall thickness and geometry. Whether the LV response to changes in hemodynamic load also adapts in a training-specific manner is unknown. Using echocardiography, we examined LV responses of endurance-trained (n = 15), resistance-trained (n = 14), and nonathletic men (n = 13) to 1) 20, 40, and 60% one repetition-maximum (1RM), leg-press exercise and 2) intravascular Gelofusine infusion (7 mL/kg) with passive leg raise. While resting heart rate was lower in endurance-trained participants versus controls (P = 0.001), blood pressure was similar between groups. Endurance-trained individuals had lower wall thickness but greater LV mass relative to body surface area versus controls, with no difference between resistance-trained individuals and controls. Leg press evoked a similar increase in blood pressure; however, resistance-trained participants preserved stroke volume (SV; -3 ± 8%) versutional remodeling of the LV in response to different loading conditions has been recently suggested, but not experimentally tested in the same group of individuals. Our data provide novel evidence of a dichotomous, training-specific LV adaptive response to hemodynamic pressure or volume loading.
Multiple congenital abnormalities of the epiglottis have been reported and iatrogenic injuries to the larynx and subglottis are well known. We present a new pattern of defect not previously reported in the literature.
Epiglottic abnormalities at two institutions are reviewed. Cases of defects involving the lateral aspect of the epiglottis and aryepiglottic fold are identified. A literature review of known epiglottic defects is performed.
Two children possessing lateral notch injuries at the aryepiglottic attachment to the epiglottis are described. Both children have a history of multiple laryngeal instrumentation attempts and prolonged intubation. Both have swallowing difficulties and are gastrostomy dependent. Congenital epiglottic defects include aplasia and midline bifidity, however, no lateral congenital epiglottic defects have been reported.
Epiglottic defects, while rare, should be part of the differential for children with aspiration and feeding difficulties. A new pattern of defect is described and iatrogenic etiology proposed.
Epiglottic defects, while rare, should be part of the differential for children with aspiration and feeding difficulties. SS-31 A new pattern of defect is described and iatrogenic etiology proposed.Within mainstream institutions such as colleges and universities, scientists and social leaders, alike, are faced with persistent and new challenges to forging paths toward inclusion among marginalized group members (e.g., Latino/a/x and African Americans). Integrating theoretical perspectives that conceptualize identity among marginalized groups as tied to culture and strengths with literatures on threat and stigma, we propose a "pride and prejudice" approach to inclusion. We provide support for the efficacy of inclusion as 2 pathways-one route that is associated with recognizing "pride" or the history and culture of marginalized groups and another that is related to reducing "prejudice" or perceived discrimination toward marginalized groups. Specifically, we demonstrate using actual demands for inclusion generated by students attending 80 colleges and universities that a pride and prejudice approach is consistent with collective calls for institutional change voiced by marginalized group members and their allies (Study 1). Then, Study 2, using longitudinal data of Latino/a/x and African American students (N = 1,967) attending 27 colleges and universities we reveal the impact of pride (e.g., taking an ethnic studies course) and prejudice (e.g., perceived discrimination) experiences on sense of belonging, and in turn academic and health outcomes (e.g., graduation rates, depression). We provide evidence for 1 theory-based process whereby individual experiences tied to pride and prejudice can impact belongingness through intragroup and intergroup relations. Theory and policy implications for institutional inclusion efforts including the importance of fostering ties to ingroup and outgoup members are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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